14 November 2025

Automating Warren Buffet. Someone used ML techniques to screen stocks using criteria similar to what Warren Buffet says that he uses to evaluate businesses. I'm surprised that his top 10 are almost all tech stocks. They have been performing well, but it's not what's in Berkshire Hathaway's portfolio. This is just an interesting exercise, but I wouldn't take it to the bank.

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just four amino acid substitutions – at positions S463, E511, Y527 and T530 – that occur in the naked mole-rat’s cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS). These small changes enable the protein to linger longer on chromatin following DNA damage, rather than being swiftly removed by the TRIM41-mediated ubiquitination that marks it for segregation from chromatin. By prolonging its presence, the enzyme facilitates the formation of a repair complex between two key proteins, FANCI and RAD50, which act together to mend broken DNA strands through homologous recombination.
This is key! Improving DNA repair will have implications for cancer treatment as well.

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North Korean social engineering scams can be quite subtle. Suspect anything that is unexpected. Being aware is key.

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Intel is not done with layoffs. 669 more workers will be laid off, and these are engineers and technicians in Hillsboro. Very sad, and just before the holidays. Many thought their positions were secure, but times have changed. And of course, Oregon suffers further with a declining tax base and more in need of unemployment support. How much can the state tolerate?

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Awful. Oregon is at the very bottom for 4th grade math and reading.  And 8th grade performance is nothing to be proud of either. The Oregon Department of Education ought to be fired and replaced. This is shameful.

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And they essentially throw good money after bad, spending it all on supporting the homeless and supporting "refugees," instead of fixing Portland so that businesses would be willing to move back in and invest in the city.

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Seattle's new Socialist mayor Katie Wilson vows to 'Trump-proof' the city, plans to enact high taxes, free childcare. Copying the Portland formula.  The West Coast states and cities have a lot more suffering to go through it seems.

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Oregon critics say new U.S. law will ‘wipe out 95% to 99%’ of hemp industry, take CBD gummies and oils off shelves. Maybe we'll see less marijuana usage in Oregon. The overall IQ of the state might increase. Less craziness, violence and traffic accidents.

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