Differences in dog aging may arise partly from specific jumping genes known as LINE1s, the authors report. LINE1s can damage DNA as they roam the genome, a threat normally mitigated by DNA methylation.More than 40 percent of LINE1-associated genome regions lost methylation as dogs aged, the study found, with different dogs declining at different rates.The loss unfolded significantly faster in larger breeds, which lost about 35 percent more LINE1 methylation annually than smaller breeds did.
The change needs to start at the top with Kotek.
For her second term, Kotek needs to adopt and execute on a vision for reviving the state by addressing the structural
issues weakening public services, rather than attempting to solve them by fiat.
She should start by focusing on Oregon’s economy — the most critical component for the state to be able to solve any of its other crises.
Ask an AI something you would not say out loud. "Is this mole something to worry about?" "Help me write my resignation letter." "Here is our customer list. Who is about to leave?"
Then ask a second question. Who has a copy now?
Not who could read it. Who holds it. For a moment, for a month, for ever.
For most AI products the answer is long, and nobody can give it to you with certainty. Not even the company whose logo is on the app.
Portland is the "City that Forgot How to Work".Gene Dieringer, a longtime member of the Stakeholders Group and of the WCBA, further elaborated: “We advised the city over a year ago that that the Stakeholders would no longer be maintaining the median islands, largely because the city said we would be liable if we did.”
Why legally liable? The Portland Bureau of Transportation (PBOT) says if citizens step in to fix or maintain public “Main Streets” (and Woodstock Blvd. is a Main Street) or local right-of-way infrastructures, they face bureaucratic, legal, and financial hurdles. Any damage to the island caused by accidents or vandalism would therefore be the Stakeholders’ liability, if they continued maintenance. Thus, since 2025, the shrubs and foliage have grown without pruning.
This is so true! Doctors need to know about the artificial intelligence tools they use. Right now, they are at the mercy of engineers who think they know how to implement AI in the clinic. So few actual doctors are involved in the design or decision-making.When a short-course provider cuts out the fundamentals — claiming that logic, data architecture, or algorithmic limits are “too complex” or “too theoretical” — they are not saving clinicians time. They are stripping away their critical armor. When you do not understand why a probabilistic model produces an answer, you cannot evaluate when that answer is a dangerous hallucination.
What is the result of this shortcut culture? A passive acceptance of systemic failure! We hear healthcare workers repeating slogans: “Well, that’s just AI; it hallucinates sometimes, it’s a black box, and it has bias.”
We have normalized the error before we even bothered to teach the mechanism! Why have we accepted that clinicians should blindly trust — or helplessly dismiss — a tool simply because we were too lazy to teach them how it actually works?
Open since 2008, the conjecture of Scott Aaronson and Andris Ambainis concerns when quantum computers can be exponentially faster than ordinary ones. Now, a research system developed internally at Physical Superintelligence (PSI), running a non-public Anthropic model, found a proof for it, settling one of the most fundamental questions in quantum computing.
The cybersecurity vendor on Tuesday launched an AI kill switch designed to let security teams stop internal AI agents that go rogue, block them from relaunching and cut off their enterprise network access. The tool is built into CrowdStrike’s Falcon Guardian platform, launched in September to secure AI agents. CrowdStrike also announced an integration with Anthropic’s Claude Cowork.
The experimental treatment uses a virus called adeno-associated virus 9 to deliver a gene to neurons in the affected area. The gene was engineered to produce proteins specifically in excitatory cells — the ones that are involved in seizures.
The viruses carried a gene that makes neurons sensitive to a specific drug, which works like a dimmer switch for the therapy. By combining gene therapy with a drug — an approach known as chemogenetics — researchers can adjust a treatment’s potency, which is not possible with other types of gene therapy.
The gene instructs neurons to produce a receptor that binds to clozapine, the anticonvulsant.
Cisco president and chief product officer Jeetu Patel ...has given a 27-year-old ex-startup founder...a new job to refactor 98% of the company's legacy code within 24 months.
The employee, Padmanabhan Krishnamurthy, joined Cisco after it acquired EzDubs, a translation startup that Krishnamurthy helped build in 2023. While having executive experience, Patel found that "Paddy" was left "buried away in the organization doing something unstrategic."
According to the report ...Krishnamurthy told him that he could rewrite Cisco's legacy code in a team of just two people, and that "even the most AI-forward people on [Patel's] own team weren't thinking that way."
As a result, he's now been tasked with rewriting 98% of Cisco's legacy code within 24 months
Higher income was also followed by subsequent decreases in agreeableness and extraversion...Personal increases in conscientiousness and emotional stability were followed by later increases in income, suggesting a mutually reinforcing cycle between these two traits and financial success. In contrast, increases in an individual’s extraversion were followed by slight decreases in subsequent income...
The agent writes code and changes dozens of files. I start reviewing the code, and the following conversation ensues:...I wouldn't be able to function. Do people really put up with this?
— Why is this function here?
— You’re right. This function isn’t needed here. (Deletes the function and makes changes to many files)
— Why did you delete it?
— You’re right. I shouldn’t have deleted that function. I’m putting it back. (Makes changes to many files again)
And I still never got an answer to the question of why that function was needed.
The unedited model plans the story for 2,400 tokens. Then it writes two lines over and over: “Wait, I need to make sure I don’t confuse myself.” and “Okay, let’s write.” It never writes the story.
So the agent did not find a math circuit. It found a general brake on repetition, and math is simply where the model loops most.
No-show “home care” work is so common in Pennsylvania that it’s no longer viewed as something to hide. In August, the federal Drug Enforcement Administration arrested a drug trafficker in the state who asked the agents to let him out of handcuffs so he could clock out of the home health shift he was supposedly working. When they pointed out that that was illegal, he seemed confused, saying, “Everyone is doing this. If this is a problem, you’ll have to arrest the whole city.”
16 times the carcinogenic impact of standard plastic straws, along with six times the acidification damage (the metric scientists use to measure changes in ocean and soil pH levels).
We gave it 19 gene therapy vectors in a spreadsheet, a mouse model of epilepsy, access to a motorize surgery rig with cameras and one goal: reduce seizures.Weird that this gets published on X instead of a research journal. And soon, there'll be more information on a Substack! AI has changed both math and science – I can't keep up!
It picked the drug. It picked the brain region. It derived the coordinates from three papers. Then it drove the stereotaxic arms into the brain and injected 250 nanolitres while watching the entry site through the rig camera for bleeding.
The scientists found that Hawaii and Easter Island were likely both settled by members of a single "ultravoyager" culture from the Mangareva islands, about 3,440 miles (5,530 km) southeast of Hawaii and 1,600 miles (2,600 km) west of Easter Island.
...earlier cuts to administrative and support staff have forced faculty members to take on extra work. Doctors and other clinicians are spending more time dealing with scheduling problems and paperwork instead of caring for patients,“We are burning out our greatest asset,” she said, adding that some faculty members have already become “disillusioned and disgruntled” or have quit, leaving their colleagues to shoulder even more work.
California-based nuclear technology developer Radiant announced that the US Department of Energy (DOE) has approved the Documented Safety Analysis (DSA) for its Kaleidos microreactor.Radiant used HALEU in the form of TRISO fuel (TRi-structural ISOtropic particle fuel).
The approval brings the reactor closer to full-power testing at Idaho National Laboratory (INL), where Radiant plans to evaluate its performance under operating conditions.
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OpenAI, Google, Microsoft, and Anthropic say they will restrict their AI crawlers from accessing a site if they encounter the shared token. Meta communications head Andy Stone also signaled support for the new setting, but doesn’t say whether the company will honor it.
The cause of this latest security incident, according to the WSJ, is a flaw in DebugBear, a third-party website performance monitoring and debugging tool that Polymarket uses.
Equity: Is the business Woman and/or Black, Indigenous, or Person of Color (BIPOC) owned, and/or does the project serve women/BIPOC communities?And Seattle's renter protections effort failed miserably, as a $39 million 254-unit apartment complex meant to serve lower-income residents and provide affordable housing failed and went into receivership.