5 June 2026

How the body creates reliable antibodies out of biological chaos. This is really cool. I bet a lot of people don't think about how the body produces antibodies that bind to antigens that we get exposed to. The immunoglobulin gene has a high mutation rate in the hypervariable region, and produces a huge variety of antibodies, hoping that at least one will be the desired antibody that binds to the target antigen. If one is a tight fit, the B-cell will internalize the antigen, digest it, and present a piece of it on the surface for a T-cell to have a look. Costimulatory molecules stimulate the T-cell to secrete cytokines that cause the B-cell to proliferate and the lymph node follicle to expand. Well that's what these scientists got to observe first-hand. Amazing to see it all play out, just as it's supposed to.

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A drug called GRWD5769 is a member of a new class of drug, called ERAP1 (endoplasmic  reticulum aminopeptidase 1) inhibitors. By inhibiting ERAP1, immunotherapy drugs like cemiplimab were made effective again.  This is great because when immunotherapy stops working, there isn't much that can be done to halt progression of head and neck cancers. But this might be effective in other areas where there is squamous cell carcinomas.

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I've posted about new myeloma treatments before, but what this article highlights is that advances in the treatment of myeloma are starting to be developed outside the United States. It seems that the advances are coming from China now. China is becoming the leader of cell-based therapeutics. The graph in the article stops in 2020. Wonder what it looks like now.

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Anxiety Is Making You Dumber. I used to think that being anxious was the price you pay for being vigilant. But after a while, your brain forgets how to step back and put danger into perspective. Then you lose the ability to assess things critically as they should be. An anxious mind always fears the worst, and forgets that much is still controllable.

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Asian vs Asian. I recently posted an article about how the engineers at Meta are, to a large extent, Chinese. They stick together, socialize together and according to the article, exclude Whites. Well now a Chinese professor at Southern Methodist University School of Business is suing that he is being excluded from tenure and promotion by an Indian department chair.  I've seen that happen where I worked. I suspect it's going on in governments positions in Portland and Oregon, and not about race, per se, but other characteristics. People hire those that they feel they can get along with, and are not threatening.

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I knew it!  Scientists have long said we can’t multitask. A new study says we can. I can walk and chew gum.

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What is the relationship between cannabis use and testosterone levels in men? The data suggest that right after use, testosterone levels are higher, but with long-term use, levels decline.  But there are many variables, and it's not clear that there is a close relationship. Today's cannabis is different from cannabis from years back, I'm sure. Legalization has encouraged the development of more potent strains.

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Sad. OHSU shelves long-promised expansion of newborn ICU. Things seem to be contracting up on the Hill.

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Seattle's US Bank center is selling at huge loss.  A 54% loss from when it was purchased. Blackstone is taking the hit and is getting out. Good for them. Katie Wilson says Bye!

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Portland General Electric announced Wednesday it plans to increase rates by 29% for large load users like data centers. Meanwhile, the utility’s residential and commercial customers will see a slight decrease in their rates. Yeah, I don't mind paying for AI datacenters (if they don't suck up needed local resources), but I don't support datacenters for crypto mining.

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Man, Oregon is always the worst in any survey, it seems. Now, Sharp rise in Oregon State Hospital’s seclusion of patients pushed state to worst-in-nation status.
In 2024, Oregon held psychiatric patients in seclusion across public and private hospitals at the highest rate in the country.
Can Oregon, you know, just not suck at something for a change?

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4 June 2026

Japanese Break Bandwidth Record: 450 Tbps On A Single Standard Fibre Pair. I still remember when before 2000, people were claiming that 2400 baud or 4800 baud was the theoretical limit of how fast we could transmit information. They claimed it was a physical limit, like the speed of light. Then someone came out with 9600 baud modem, then 19200 baud, and so it went. Glad we didn't give up the effort. 🤣

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Cutting a photon in two creates an infinite swarm of particles. My first reaction was "What!??" but it turns out this is just theory. They haven't actually split a photon. But yeah, photons are weird.

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‘Bots have now passed human traffic online,’ Cloudflare boss laments. Yeah, I'll bet he laments. Pretty soon there will be so many bots that Cloudflare's latency will be long (and maybe will jam its servers with so many requests).

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"Stop scanning QR codes, you dolts" QR codes are like shortened links. You have to trust that all that's happening is that you are being taken to a new link. That may not be the case. Plus, when you see a QR code from far away, NEVER scan it. It may not be real.

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Typical Feynman. He even worked out an algorithm for eating out at restaurants at an unfamiliar city.

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As AI gets better, it reveals an empty promise. Here's something that almost no one talks about.
“I must study politics and war that my sons may have liberty to study mathematics and philosophy,” and so-on and so-on until the grandchildren can enjoy painting and poetry. So, ideally, after we slog through pre-transcendence, AI will make us all theater kids.

Nobody is working less, they’re just earning less. And as more AI-related companies reap trillions in valuation, the current US regime is looting the social safety net — the kind that must exist if we’re all going to become out-of-work theater kids. 
SNAP abuse and fraud need to be cut. No question there. But the impact of AI on the workforce is a completely separate matter. That's not on the administration that companies are finding less need for humans to do rote work. If you don't want AI to be used to book your next flight or to summarize your emails, then don't use these services. I don't.

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Why Are Men So Bad at Making—and Keeping—Friends?  There's no advocate for the common now that Jordan Peterson is out of commission. It's easier to just communicate online than meet in person. It's harder to find activities to share. And as we get older, friends leave us, and it gets harder to meet new friends.

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You’ll never guess who made the first wireless telephone. I didn't know that either.

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3 June 2026

Oracle may have to exit the EHR business. Looks like they need to maintain liquidity by selling off assets. So who will take over as Epic's main competitor?

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LongCOVID has long been associated with symptoms of fatigue, cognitive difficulties, anxiety, depression. So it was a bit of a surprise that brain PET and MRI scans did not reveal widespread inflammation. Instead, there were signs of "increased cellular activity in the hippocampus and amygdala". These are areas associated with new memory formation and anxiety/fear. This is a weird finding. Paper here.

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Mathematicians are finally getting nervous. I think a lot of them felt that AI would not be smart enough to take something as abstract and difficult as mathematics. It wasn't just memorization, they argued, and would require creativity. Well now it's happening. 
But for students, professors are seeing that with greater AI usage, there are dwindling math skills in UC Berkeley computer science classes. They're not using AI to empower themselves. They're using it to replace thinking.

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This is interesting: if you enter your LLM prompts using casual language, you'll get answers. But they won't be as good as when you use technical jargon to show domain mastery. Be precise and specific, and the LLM will respond with better results – more of what you were probably asking for, or should be asking for.

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What initially started as simply wanting to write a Linux tool for communicating with my speaker ended up with me discovering vulnerabilities which allow any attacker within a ~15M range of any Katana V2X to turn it into a covert spying tool and Rubber Ducky - all without ever having to pair with or physically touch the device.
Cripes. As if I didn't have enough to worry about.

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This is funny. Claude 4.8 Max will apparently generate a verbose response to – nothing. Even if you have said nothing, if riffs off the nothingness.

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What's the tastiest sparkling water? Here is your answer.

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How long will it take to rebuild Blue Origin's damaged space pad? A long while. But they are using this opportunity to redesign.

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Oh-oh. Intel bit off more than it could chew with 18A process node. Dang, just when I thought they were emerging from their rough times.

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Looks like the Waymo isn't quite ready to take on the world. I don't want these vehicles near me. Stay in the Bay Area, please.

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A new diabetes pill burns fat without the downsides of Ozempic? Look at the muscles on the guy in the picture. Who wouldn't want to look like that? But it's a GPCR-based kinase β2-adrenergic agonist. Haven't we been there before with mirabegron? Well, maybe this is better.

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I also tried paraxanthine based on the LessWrong post. And it's exactly like it was described. It improves alertness without the jitters and nervousness. The onset is smoother (everybody seems to use that word). It's perfect for the afternoon, to supplement the morning coffee.

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The journal Nature is letting its hair down. Nature is going to pair up with TikTok. OK, I guess. Gotta get GenZ's attention I guess.

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Sci-Fi author Ted Chiang is convinced that AI is not conscious. I think it's emergent behavior. Maybe right now it's not conscious. But the emergence will be subtle, and it may not be so obvious at first.

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2 June 2026

Florida sues OpenAI and CEO Sam Altman, claiming company concealed serious risks of ChatGPT. Why Florida? And why all of a sudden? I've read that this is a way to sideline the company paving the way for the ascendancy of xAI, to help Elon Musk. Sama has certainly got to be sick of spending so much time in the courtrooms and less time developing the next GPT, vLLM or whatever China is developing. They're not spending time defending lawsuits like American AI companies.

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Claude Opus 4.8: Capabilities and Reactions. I'm glad someone else feels the same way about 4.8. It certainly performs better on the benchmarks, but somehow, I prefer working with 4.7 better. I recently had a code problem that 4.8 was struggling with, and I posed the same problem to 4.7 and it solved it promptly. Also, 4.7 has a better personality. I fixed the system prompt in 4.8 to make it more in line with what I'm used to.

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Gotion Unveils Sodium Battery Products With 261 Wh/kg Energy Density And 20,000 Charge Cycles. Remarkable. Elon had said that Tesla is not an auto company, but more a batter company. Yet you don't read about announcements in battery tech breakthroughs from Tesla as you do from China. Researchers don't seem to get bogged down in extraneous matters.

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While some of those changes (28.8%) relate to how often or how much people vape, a much greater portion (66.6%) is linked to the type of flavors and devices they use. The findings underscore the role of flavor and device type in the biological effects of vaping and could have regulatory implications as the Food and Drug Administration (FDA) moves to approve marketing of flavored vapes.
It's just in oral epithelial cells, but holy crap, I'll bet vapers don't know this. Drinking coffee affect gene expression, too, but it's more like 140 to 300 genes. And other studies measure it differently. So it's not a direct comparison. But I'd be a little concerned.

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Google Maps is ditching the Mercator projection in favor of a globe projection, like Apple Maps. Good.

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Wangdoo Tech has put out a Tiiny Pocket AI Lab. It's a Kickstarter project. There's no GPU – only an NPU, so you can't use CUDA code. It's not a muscle car, but good for running small to medium sized projects. But it's about a third cheaper than a DGX Spark.

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Privacy isn’t dead: it’s just that tech companies have made it inconvenient. Don't like the heat? Stay out of the kitchen. It is very inconvenient to take privacy precautions.

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This is a breath of fresh air. Battle Ground takes a stand. The applause at the end expresses what most people feel. They've had enough. Antifa fatigue.

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Gov. Tina Kotek Bragged About Oregon's Graduation Rates. There's Just One Problem. Yeah, that an Oregon diploma doesn't mean as much anymore. Not requiring any standards means quality degradation. Look at the Univ of California professors, pleading with schools to require the SAT again. So they don't have to waste time teaching remedial classes. Enough pandering to DEI principles, already.

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Katie Wilson took down the barriers people put up to stop neighborhood gunfire. Guess what happened next? Gunfire returns to Aurora Ave less than 48 hours after Seattle replaced neighbor barriers.

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Seattle posts nation's fifth-largest population gain; international migration fuels growth. International migration? Where do you think they are coming from?  Here's some data:

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A University System Went All In on A.I. Now It’s Tearing Itself Apart. Around the turn of the century, there was a demand to learn about computers, and Borders Bookstores had a section on computer-related books. But next to the tech magazines, the books that were there were about how to use Excel, Word, or Access. These books replaced the ones that taught coding, such as DOS, Turbo Pascal, Visual Basic, C+ and Java. So you weren't really learning computer science. You were just learning how to use computer tools. In the same way, kids just learn how to operate chat bots and create bespoke graphics and videos. And vibe code some app that they hope will make them rich. But that's not really learning AI, and they have no marketable skills. No wonder they hate it.

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1 June 2026

Google planning to release millions of mosquitoes into California & Florida to help stop diseases. Why is this search engine company involved in something like this? They aren't the government. Did people have a vote on this?

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People really like Kagi search. These are recent reviews, too. I wish their API costs were lower, however. That would be my dream.

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Microsoft builds its ultimate MacBook Pro rival with the NVIDIA powered Surface Laptop Ultra. This looks like an interesting machine. I would not want to run Windows, however. Really waiting for something big to come to the Mac.

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Why so many Americans moved to the middle of nowhere. Centralia, Washington? Really? Wow, that's really getting away. I guess people are really fleeing living next to orcs and goblins.

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Kayaking in Oregon now requires permit now. This is a bummer. Nickel and diming people now. Like all those parking fees. It's crazy.

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31 May 2026

Nice to hear from Doc Seals again.  How DuckDuckGo Can Be a Hero. Some people dislike DDG because they get some of their search feeds from Bing, but Bing has come a long way since its early days and the results are quite good. Their bad rep just hasn't left them, and people still think of how it was during the Ballmer era. It's on par with the others now, and its interesting that although reviewers can't really find major differences between Google and Bing, they just can't come right out and say that Bing is a good alternative to Google. But few will ever use Bing as a verb. It's really too bad that they dropped API support.

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GammaTile is a new way of applying brachytherapy but embedding high dose radiation emitters into a polymer which you leave in the body and which eventually dissolves. This reminds me of the Gliadel wafters, which were a polymer wafer coated with BCNU chemotherapy. That treatment fell by the wayside as better treatment replaced it.

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Someone created a repository for Abstruse Goose comics, which I used to enjoy during the beginning of the century. The author has remained anonymous. We still have XKCD, though.

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Maybe this is why Meta seems to be struggling lately. This post about how the company's tech staff is overwhelmingly Chinese has caught social media attention. Doesn't sound like a place I'd want to work now.

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US healthcare still stupidly expensive, with pathetic outcomes. I was really hoping that the Trump administration was going to fix Obamacare, but it seems to have fallen lower in terms of priorities. I am very afraid that when the Democrats next take power, and they will someday, it will be turned into a completely socialized system. That will be a sad day. People believe that Scandinavia has a socialized medicine system that works, but they really don't, and the U.S. is not Scandinavia.

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Is migration into Oregon cooling again? Driver’s license data suggests a slowdown. Most immigrants are from California, and this probably accounts for why Deschutes county has become Blue. But in-migration is slowing down, which is not surprising. We're not getting the best and brightest to come to the state to work.

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30 May 2026

The Erdös unit distance problem was recently cracked by a GPT model. It's interesting that OpenAI's models are solving these math problems, while Anthropic's models are solving everything else. Is there something intrinsically "mathy" about OpenAI's models?

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Most Americans Aren't Convinced Humans Are Causing Climate Change. Agree with this – climate is changing but I've yet to be convinced that anthropocentric causes contribute very much to the overall picture. Global temperatures fluctuate much as they always have. The sun plays a much more significant role.

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The physics of espresso coffee. So much complexity in a simple coffee drink. I really like my Kinto drip system. The coffee is really good.

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Ten days with someone can make you both good buddies, but by ten months you'll be at each other's throats. I bet it varies from couple to couple. 

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The computer science algorithms behind Google and Apple Maps. Engineers have to know this stuff.

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AI billionaires brace for pitchforks. The dotcom craze was OK, because everyone was getting wealthy. This time, it's different. It's really tacky to display your wealth, like Zuckerberg displaying his Wingman and Launchpad yachts in Seattle. Especially after all the layoffs at Meta. Read the room, Zuck.

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Portland ranks near bottom of North American cities in new downtown perception survey. No surprises here. I haven't been to downtown Portland in ages. 
Among North American cities, Portland ranked last in the share of respondents who described downtown as “beautiful,” with only 3% agreeing with the statement. The city also tied St. Louis for the lowest rating on “vibrant,” at 58%.

Just 62% of respondents said Portland is “enjoyable to walk around,” tying the city with Baltimore for the second-lowest score in that category. St. Louis ranked lowest at 58%.

Portland also ranked near the bottom on cultural identity and inclusiveness measures. Only 47% of respondents considered the city “iconic,” the third-lowest score among North American cities surveyed, ahead of only Phoenix and San Jose.

On whether downtown feels “welcoming to everyone,” Portland scored 58%, tying Baltimore for third-lowest rank.
I wonder where Seattle ranked.

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29 May 2026

Teclistamab extends remission in relapsed myeloma, with 70% progression-free at 18 months. Now this is truly remarkable, as anyone who has taken care of refractory myeloma can tell you. To stable disease at 18 months in refractory disease is incredible. Overall survival was improved as well. You still have to deal with cytokine release syndrome, but that's not unusual in myeloma, especially in people who have experienced daratumumab. But adverse events of grade 3 or 4 occurred in 84.9% of teclistamab recipients, so definitely, there is risk, as grade 4 toxicity usually lands you in the hospital at least for a while. Paper here.

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Perfect randomness realized for the first time. The standard for perfect randomness has changed over time. Now we have cryptocurrency and quantum computing, so what is considered random has to be perfect. No hidden probability distribution that can be reverse-engineered.

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I saw this article (Calling Doctor GPT: AI responses to healthcare queries are nearly 76% accurate). I saw that they were using really old LLMs, and brushed it off. We know that medical chatbots are not trustworthy to be accurate, but then this article came out which used modern LLMs (Beyond Benchmarks: Disagreement Among Frontier LLMs on Real-World Fact-Checks). Clearly, the reliability of chatbots is still less than ideal.

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New report shows annual app subscribers rarely return after they cancel. Psychologically, I'm more likely to continue using a good app if I pay once and can use it with free updates for a year or so, and then have the option to pay for a license upgrade if I want. This stikes the right balance between overly greedy developers and those who just want to be supported for their hard work.

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Blue Origin's Earth-Shattering Kaboom. By now, most people have seen the video of the Blue Origin explosion. That was huge. So huge that it may put Blue Origin out of commission for a while. Like well into 2027.

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Small colleges are hurting. One estimates that "442 of the approximately 1,700 private, nonprofit, degree-granting colleges and universities in the United States could face financial exigency within the next decade." Western Oregon, Southern Oregon and Eastern Oregon Universities as well as Portland State University are experiencing financial trouble. Enrollments are down and expenses are increasing. I'm sure many prospective students are wondering whether it's really worth it to go into debt for little return.

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I hope that mail-in voting will eventually disappear. No more cheating and post-election surprises!

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Vaccination Rates For Oregon Students Hit New Low in 2026. Trust in the medical profession is very low.

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Is Tesla's Model S Plaid a faster and more powerful car than the Ferrari Luce? That would be an embarrassement.

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“Can I just say f**k AI, f**k AI, f**k AI?” the comedian, actor, and rotating host of The Daily Show asked in his keynote speech during the Class Day celebration on Wednesday. The crowd at Tercentenary Theatre, made up of the graduating Class of 2026 and their friends and families, answered him with a roar of approval.
College kids sure love to f*ck things, don't they? But this guy gets it right.

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“Raccoons live in alleys, storm drains, garbage nights, and morally humid environments,” it wrote. “Frogs have existential agency, while raccoons have logistical agency. A frog at a VC afterparty seems like an omen. A raccoon at a VC afterparty seems like it got on the guest list … Think: alley behind a conference hotel, the loading dock of a casino, the VC afterparty where everyone is saying ‘alignment’ but meaning ‘exit liquidity’ … Alignment sounds like ethics, safety, shared goals, humanity, the future. It has dry-cleaned blazer energy … Exit liquidity is socially clammy.”
Claude would not write this. This smells like ChatGPT.

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Gen Z men want kids. Gen Z women have questions. Modern society is so messed up. Humans can't accomplish simple biology now. 

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Kyoto University Hospital launched the first human trial of an experimental drug named TRG-035. The initial safety study enrolled 30 adult males who were each missing at least one tooth. Developed by biotech startup Toregem BioPharma, the drug blocks a specific protein that acts as the body’s molecular off-switch for tooth development.
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Scientists accidentally discover sea cucumber with 'tissue immortality'. Why is it that all of nature's creatures with regenerative superpowers like this have to be ugly? Like Deadpool.

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Anthropic reaches valuation of $965bn, beating OpenAI to become world’s most valuable AI firm. So different from a couple of years ago. Now, it seems that all OpenAI does it get embroiled in lawsuits. GPT models don't generate any excitement anymore. We look forward to the next Claude model. Or some Chinese model.

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Functional recovery of the adult murine hippocampus after cryopreservation by vitrification. Well, if we can't solve the challenge of storing our memories in some LLM, then maybe we can freeze our brains instead?

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28 May 2026

Is Microsoft ditching OpenAI for Anthropic? I think Microsoft is just hedging its bets. I would. OpenAI is no longer the recognized leader. It's Anthropic. They've got the best models. Today, they released Claude 4.8 Opus. Early users like it. Gonna give it a try. Claude 4.7 was already great as a coding assistant. 4.8 still has 1M token context window. Can't wait to see what this can do.

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Oura Ring 5 has been released. This one is smaller than the last version, and can monitor blood pressure now. It also measures nighttime breathing patterns, so it can check for sleep apnea, which is quite common. A lot of people are put off by the subscription, but that's life.

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Earlier this week, AIR Capital analyst Pierre-Olivier Essig said the Luce looks like a "mix between a Honda Accord EV and a Tesla."
Ouch.

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Various LLM smells. Some examples of AI writing styles:

Way too many punchlines

  • "Humans trust symmetry because it feels like intelligence made visible."
  • "The Tiger fit the story. Jin-yong fit the physics."
  • "Symmetry becomes a trap."

Consecutive short sentences

  • "Yet the tilt is not an accident. It is the shape of the optimum."
  • "Then AlphaEvolve arrived. It had no preference for symmetry. No aesthetic prior. No instinct to preserve harmony."
  • "These examples are not decorative. They form a distributed argument."

"X is the Y of Z"

  • "Cringe is the visible signature of moving along a gradient you chose."

"it's not just X, it's Y"

  • "solutions that do not merely satisfy the constraint but satisfy the aesthetic instincts"

Yeah, we've seen this. It's like Linked-In speak.

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Not everyone likes Google's new search strategy. It's rough being a business that depends on Google searches. And I can't believe that Google AI still has tokenization problems. Geez man, we've solved that years ago already. Try to keep up!

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Their breakthrough pushes superconductivity to 151 Kelvin (minus 122°C), beating a record that stood for more than 30 years.
Still way too cold. That's why this isn't making mainstream news. 

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Thoth app for ADHD and autism. This kind of app is really what should be developed for medical transcription. Instead of the not-so-private app that doctors are forced to use. (Yeah, I know, HIPAA rules, etc. But still.)

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The laser device that blasts mosquitos is still around. I didn't realize Photon Matrix is a Chinese device now.  Lowell Wood couldn't get enough interest in the U.S. so the company is Chinese now. Watch the video of it in action – quite cool.

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Inside the Collapse of Providence Health Plan.  One thing I've noticed is that many companies tend to think that in order to get good leadership, you have to do a national search and import from the outside. How many times have we seen that fail. In Oregon. In Portland. At OHSU. And here, Providence Health Plan. To me it says something about Oregonian insecurity. 
I would never have dreamed that this company would collapse. I feel bad for the people in the company, who are now out of a job.

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Mayor Katie Wilson’s policy adviser leading her most ambitious project to shelter 4,000 people resigned Wednesday morning, the mayor’s chief of staff confirmed.
Jon Grant’s exit comes weeks after Wilson replaced her chief of staff and in the wake of a deteriorating relationship between her office and the Seattle City Council.

27 May 2026

Scientists say they’ve reversed brain aging with a simple nasal spray. 

The therapy relies on microscopic biological particles called extracellular vesicles (EVs). These tiny structures naturally transport genetic material between cells. In this case, they were loaded with microRNAs, molecules that help regulate important biological processes in the brain.

"MicroRNAs act like master regulators," Narayana said. "They help modulate and regulate many gene and signaling pathways in the brain."

Researchers delivered the EVs through a nasal spray, allowing the treatment to bypass the brain's protective barrier and travel directly into brain tissue.
The secret sauce is in the microRNAs.  "According to the researchers, the therapy suppressed inflammatory systems such as the NLRP3 inflammasome and the cGAS-STING signaling pathways, both of which are strongly linked to aging related brain inflammation." Paper here.

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Websites have a new way of tracking you. If you surf other websites at the same time, your disk access patterns can give you away. Of course, they all have to use this technique, and there needs to be a central data collection repository for this to be useful. 

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Just say NO to AI note takers. I don't care how safe or private they claim to be.

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Google is losing its core search business. I'm reading about more people switching to Kagi search as well. What about Bing search?

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US law enforcement warns of “anti-tech extremism” as AI hatred grows. America is rapidly becoming a society where violence is acceptable if you disagree with something.  Soon, it can be said that a democratic republic is not suitable to govern America.

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Dysfunction in a nutshell. Portland leaders launch fast-track renaming of César E. Chávez Boulevard. Why must Portland name a city street after a California labor union leader? Or California farmers? Or anything regarding California? No input from people who live on the street. Breaking their own rules to rush this through.

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Los Angeles mansion tax backfired. LA needs Spencer Pratt so badly. Portland needs to learn from this.

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Seattle Redditors unhappy about EV charging station vandalism. Out of control, they say. But hey, defund the police. Support "harm reduction". And f*ck ICE, who just wants to remove criminals, right?

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