Sugoi & Yokunai

By connecting the hindbrain to the central amygdala and dopamine neurons, these drugs effectively “turn down the volume” on the desire for high-calorie foods. This discovery explains why patients often lose interest in “cravings” but also sheds light on side effects like nausea and a diminished sense of pleasure.

A security researcher decompiled the White House’s new official app and found some alarming stuff buried in the code, including a hidden GPS tracking pipeline, JavaScript loaded from a random GitHub account, no SSL certificate pinning, and an in-app browser that silently strips cookie consent dialogs and paywalls from every page you visit.

He had really defined himself as being the pro-tax guy in the Legislature. But I think he shifted pretty quickly when he realized that just being pro-tax wasn't really getting him anywhere, and it wasn't really gaining traction. 

In his telling, he says, "It's not that I'm necessarily anti-tax anymore, but my ideas for what that tax should buy and how effective it should be have been shaped and shifted by the time that I've spent in the Legislature.” Now, he sounds a little bit more like the kind of standard Democrat of the Seattle area, which is, "We can stomach taxes when we believe they are worthwhile." But the chamber, and Nguyen by extension, now believes a lot of the taxes that are being discussed and proposed are not worthwhile.

"The IPCC and broader research community has now admitted that the scenarios that have dominated climate research, assessment and policy during the past two cycles of the IPCC assessment process are implausible. They describe impossible futures."

Nature has retracted a paper that claimed AI had a positive impact on student learning. 

Not good. 8 in 10 Chatbots Inclined to Assist Users in Planning Attacks. Guardrails, we need better guardrails. There are too many crazies out there. We don't need to assist them.

This shortage has ripple effects. When defense attorneys are unavailable, cases stall. When cases stall, victims wait, evidence ages, and law enforcement resources are tied up longer than intended. Prosecutors, who depend on the movement of cases through the system, face mounting caseloads of their own. The result is a system where delays become routine rather than exceptional.

Tessellations set out to offer an alternative to the cutthroat competition rampant in many schools. It provided nature programs, emotional development and flexible curricula that gave teachers freedom in what they taught and how they taught it.
But the Silicon Valley ethos of its leaders and parents clashed with that gentler vision.

"With my amazing psychic ability, I can predict any article involving California will have the word "lawsuit" in it somewhere."

"Seattle used to be a place where you were excited to build something, where it was celebrated, where you could imagine creating something from nothing and that you could manifest that," Proudman said. 

"And, for many years, for probably 20 years, that was the culture here," he added. "We had a vibrant startup community. We had a very supportive startup community. And the ecosystem worked. It helped build the companies. 

"And then, for whatever reason, sort of over the last four or five years, we've seen this shift where entrepreneurship is now villainized. And it's an unfortunate and sad shift in what otherwise has been a phenomenal place to run businesses."

Sympathetic nerves, the same ones responsible for the “fight-or-flight” response, can actually inhibit tumor growth. By releasing norepinephrine, these nerves flip a molecular switch on immune cells, preventing the tumor from recruiting the cellular allies it needs to thrive.

Oregon hadn't cleaned out its voter rolls in about 30 years in defiance of the National Voter Registration Act (NVRA). State officials settled a lawsuit with Judicial Watch, agreeing to clear out ineligible voters from rolls, starting with 160,000 voters who are dead, moved, or otherwise not voting in multiple elections. So it is that we find out Oregon has agreed to take off 800,000 ineligible names from its voter rolls, which represent 25% of all Oregon registered voters. 

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The ZFC axioms are often regarded as perhaps the most universal truths that humanity has managed to articulate — for while it may be possible for physicists to imagine universes in which physical laws are turned inside out, mathematical laws will remain constant.

It is a paradox without resolution: The foundations of mathematics are as universal, as solid as anything humanity knows, a core part of nearly every mathematical truth. And yet they remain simply what we choose to believe.

From the insurance side] the tradeoffs here are individual versus macro scale optimization of health outcomes + patient comfort, while optimizing and operating under constrained resources ($, limited numbers of medical machinery, limited numbers of providers, limited numbers of providers with the appropriate specialty).

The idea is that we only dedicate resources at scale to the things with high signal to noise ratio, and the highest signal is patient discomfort.

In your case, that discomfort requirement is clearly met. But that doesn’t mean jumping straight to a test is best for society as a whole -- the symptoms may resolve on their own / with medication before you’d even get the results back, the test may/may not find anything, etc.

“Do the thing cheapest/least resource intensive thing that’s likely to work first, then move on to the alternative.”