Sugoi & Yokunai

Apple announced the new M5 MacStudio today. Now it's up to 36 cores of CPU, compared with the 32 cores in the M3 Ultra model. Hopefully it will still come with 512 GB of unified memory. Can't wait till pre-orders open next month.

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Whoa. A worm frozen in Siberian permafrost for 46,000 years was thawed in a lab dish and simply woke up, began eating, and started reproducing. Simply incredible.

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Experimental compound helps burn fat without muscle loss. It's called 5-tetradecyloxy-2-furoic acid (TOFA). It is an inhibitor of acetyl-CoA carboxylases 1 and 2 (ACC1/2). Finally, something that can combat obesity. Paper here.

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How well do COVID antivirals actually work? Not as well as we thought. Well, it seems that more mainstream outlets now feel that it's safe to critically review SARS-CoV2 antivirals. I wish they were so bold during 2020-2022. Back then, only conservative sites would dare to mention that these medicines were less effective than touted. But why are we still talking about Paxlovid and molnupiravir?

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I wish there were an easy way to measure how much is optimal. Too much or too little sleep may make your body age faster. This is likely why stress ages you. Not enough quality sleep. 

And not only that: Depression may shut down the brain’s ability to make new neurons.

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Some progress on proving the Riemann Hypothesis: A new ceiling for Λ: the de Bruijn–Newman constant is at most 0.1787854.

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What you do with a billion dollars? Interesting thought experiment. The life you really want it more accessible than you think.

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For all those people who think that Flock cameras don't actually solve crime, read this story. It helped stop a mass murderer. What is really needed it surveillance on just bad people, not good people. But how do you do that?

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I often disagree with Lisa Reynolds, but this is one area where we agree – tougher restrictions on cannabis use. People have already forgotten the destruction of opium dens, brought to America by the Chinese in the 1800s. It's the same vibe. We already know what happens. People don't know how to control themselves.

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Some good news at last. Genentech plans $750 million Hillsboro manufacturing expansion, adding 250 jobs. Congrats to Hillsboro for scoring this.

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Even papers from Google DeepMind contain hallucinated content. You'd think they'd be more careful. And I didn't know of this company, VerusCite, that checks for fabricated AI-generated citations. Could come in handy.

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Apparently some people feel that time is flowing back to normal now that the Large Hadron Collider is at rest. Come to think of it, I had been feeling that time was proceeding a bit faster than usual, but I just chalked that up to age.

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Here's a simple way of learning JH Conway's trick of determine the day of the week for any given date. Simplest explanation I've come across.

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Chinese scientists have developed a genetically modified bacteria that reacts to intestinal glucose by secreting GLP-1

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Someone created a skywatching app that tells you the best time to see an astronomical object. Don't know if it works for comets.

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Would be a bummer if we had permanent Daylight Saving Time. Americans didn't like it before, they probably won't like it again. 

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No. Oregon Universal Health Plan Proposes New Taxes to Replace Premiums and Deductibles. The state doesn't have money for this. They can't raise taxes high enough to support this. People won't be able to survive on their paychecks. Unless you get no care for your insurance. This is a terrible idea, and should be scrapped.

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Seattle's real estate market is starting to collapse. Thanks to Democrat governance and the current socialist government.

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Wow, we might have a Republican governor after all. SCOTUS upholds Trump's executive order limiting mail-in ballots. 

The first instructs the Department of Homeland Security to create lists of the adult U.S. citizens in each state and to send those lists to states at least 60 days before a federal election. 

The second provision commands the U.S. attorney general to “prioritize the investigation and, as appropriate, the prosecution of State and local officials … who issue Federal ballots to individuals not eligible to vote in a Federal election.” 

The third provision requires states to give the U.S. Postal Service a list of voters to whom the states intend to send mail ballots, and it prohibits the USPS from mailing ballots to voters who are not on the lists of “enrolled” voters that the USPS will create.”

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Looks like smoke will be back in PNW skies tomorrow. There are six plumes and smoke from them will be blowing our way.

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Other people have wondered whether Moderna's melanoma mRNA vax has been overhyped. I suspect that the pembrolizumab is doing much of the heavy lifting, They say it's more than just the checkpoint inhibitor, but their data is not available to be examined, so it's just gossip just yet.

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Hidden Hazards: Nontargeted Chemical Analysis Reveals Widespread Contaminants and Mislabeling in Personal Care and Cleaning Products. The list of products is here. This would be great to have an LLM scan ingredients of a product against this list. LLMs have made data analytics much easier for the consumer – you just tell the LLM to do the analysis, like an assistant.

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One of the drawbacks about Markdown editors is that you have to have a screen for entering the text and markup, and another screen to see the results. Like an HTML editor. There's a new editor that purports to eliminate that need - the Concept Writer. I'll give it a try, as this has been my greatest problem with Markdown. Too bad there's no free trial – you have to pay just to try it. ☹️ On the plus side, it's a one-time payment, not a subscription model. 

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The Economist and MedPageToday both decry the Fauci-hate. The Economist focuses on how the deaths in the U.S. were the real problem that we should be focusing on, and says:

Dr Fauci’s private diary has exposed his vanity, his delight in every gushing appraisal by the media or some celebrity. But the diary also reveals a conscientious public servant trying to save as many lives as he could, struggling against the constraints that hobbled America relative to its peers. His summons before the Senate committee was surely intended to humiliate if not incriminate him. It should embarrass the entire country.

MedPageToday says:

I think it's debatable that Fauci was saving as many lives as he could. Why did he not disclose the hazard of giving the vax to pregnant women? Why did he make it difficult for any research to be conducted on stopping SARS-CoV2, such as repurposing drugs, or recommending vitamin D, encouraging diabetes and hypertension control, getting more exercise and losing weight? It was just vax, vax, vax. And not protein subunit vax, like Novavax, but just the mRNA vax. Why did he discount natural immunity so quickly, when there were studies that showed it was protective, before forcing it on healthcare staff, who had to quit if they didn't submit to the jab?

Fauci is not the "conscientious public servant" you think he is. He was arrogant, vainglorious and self-aggrandizing. 

The real scandal is how the medical profession suddenly shut off their collective brains and took in the foolishness about six feet of distancing and the need for worthless masking. C'mon doctors! Why didn't you speak up about the very concerning surge in VAERS submissions? The draconian measures when in reality, the bulk of deaths occurred due to policy decisions in New York and New Jersey? Why didn't you doctors speak up about the inappropriate use of 40 cycles of PCR to make the diagnosis of COVID-19? Why didn't you speak up about BLM protests, and how they were spreading infection? Why did hospitals (like OHSU) condone TikTok doctor and nurse dancing while patients couldn't see their loved ones dying? 

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Chinese Institutions Are Building AI Models Of American Voters—And Testing Political Messages On Them. Why do you think we spend time and money to do this? Purely for academic interest?

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The search for consciousness inside AI. Real consciousness is not just detecting references to related topics when prompted. I'm interested in whether signs of thought processes occur spontaneously, when no one is looking. That's consciousness.

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Optical Earth. This is what Earth looks like from space at the current moment. In case you were curious. You can't zoom in very far, as you can with Google Earth. And there is still a polar artifact. But it's the closest think to being an astronaut. 

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The movie The Wicker Man, was conceived as a trilogy, and the director's sons have finished a third movie called The Wrath of the Gods. I did not see The Wicker Tree. Without Christopher Lee and without the music of Paul Giovanni, it's not the same.

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We gave nine LLMs the same PDF. Two answered without reading it. Open-source models really lag behind frontier models. The authors used pdf.engine (which seems to be the Adobe plug-in), which I've not used for PDF parsing. I've used pdfplumber, and it's worked well.

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iPhone 18 is going to introduce a new color - dark cherry. The design hasn't changed for years, since the Jony Ive days. Apple no longer dazzles.

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Turn any screenshot into a shareable link. I used to use Imgur for this, but it was cumbersome. Now there is SCREEN2LINK.

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What is a datacenter – explained for 3rd graders. Building a datacenter is pretty complicated.

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China joins Europe in scrapping Windows for Linux. Strangely, I get the sense that Microsoft doesn't care anymore. It was a good ride, eh?

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Cliff Stoll is still amazing. I sense that Doc Brown from the Back to the Future movies was based on him. What keeps him going?

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Well good. Multilingual people may have brains up to 13 years younger. Do computer languages count? 

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Greenwich moon time? The high-stakes race to set lunar clocks. This something that mankind has not yet had to do before, and of course, general relativity must be taken into account.

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Reflect Orbital plans to deploy space mirrors could jeopardize the night sky for many. Why?

Solar panel charging? Eh, no. This is stupid. What's next? Fans in space so that windmills will spin longer? For a concept called renewable energy, things are getting far-fetched. And won't these mirrors raise global temperatures? I thought people were against that.

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Will this be Portland in the future? A socialist dystopia?

Download SruCCT6rqyW-5ORi.mp4

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Does the skull bone marrow harbor its own immune system? Researchers suspect mice skull bone marrow has a separately regulated immune system, even containing follicular T-cells! I've not heard of that outside the thymus. It's suspected that humans has something similar. What it all means will be fascinating to unravel, such as why a separate system was felt to be necessary, and how does it interact with the immune system outside the CNS.

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Meta's recording glasses are showing up in public now, and it's getting hard to avoid being recorded. Even teen boys are using them to harrass girls. Some needs to invent jammers for these devices. But then Apple may put cameras in AirPods, making these things ubiquitous. Fck.

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The city of Cupertino is 70.9% Asian. But the TV show Cupertino has no Asians. They have an Indian guy in a minor role but that doesn't really count, does it? It's not really Cupertino is it? I'm already used to movies set in Japan have a Caucasian lead, but at least there are Japanese people in it, too. I guess they didn't want the TV show to have kung-fu or have any subplot with organized crime or prostitution. The Asian activists are already up in arms about this, but give it up already. When I was a kid, I watched the TV series Quincy, and remember seeing Robert Ito play a regular lab assistant, Sam Fujiyama. But true to the stereotype, even at home, he had a lab where he did extracurricular work. 😆  Let's face it – Hollywood doesn't know what to do with Asians.

––– 良くない–––Speaking of Asians, here's an important study: Cognitive performance among diverse Asian American subgroups. Some interesting observations. Filipinos started lower in executive function and declined the most. Japanese participants started with higher executive function but eventually declined to join the others. And this was concerning: "Interestingly, we found that Japanese and Filipino participants who were born in the US and had ≥college education had faster declines in executive function and verbal episodic memory." They didn't specify why the declines were different, but it was speculated that it might have to do with blood pressure. I suspect it's dietary and genetic as well.

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Shenzhen Night Walk. This is what life looks like in a country where they don't fret with climate change crap, and where people are respectful of property and behave themselves. You can have nice things. Wow.

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Something positive from OHSU: Triple-dose regimen may permanently clear HIV in infected newborns. This study is interesting, and was done in rhesus macaques at the Oregon Primate Research Center, so it's good that this still exists, despite all the activists that want to close it. The treatment consisted of the antiretrovirals: tenofovir disoproxil fumarate, emtricitabine, and dolutegravir, as well as neutralizing antibodies, PGT121 and VRC07-523LS, given subcutaneously. But the secret sauce was the agent leronlimab, which is a monoclonal antibody against CCR5, a chemokine receptor and a co-receptor for HIV binding. (Chemokines are fascinating.) I remember that the Vancouver biotech company, CytoDyn, tried to develop this, and experimented with this as a cancer treatment. They even tried to see if it might be effective against COVID-19. The company had a stormy period, and I'm glad that it survived with new leadership. Paper here.

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Of course. LinkedIn Has Accidentally Become a Dating Site. Now you can't trust anyone's profile.

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Oura faces lawsuit accusing it of misleading consumers about sleep-tracking accuracy. This would be the only reason I would get an Oura ring, but after doing some research, I wasn't convinced it would give me the information I really wanted. To really track sleep accurately, you need a more cumbersome and expensive device. Not for just the mildly curious.

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Alcohol use disorder slowly declines across the USA, but cannabis addiction climbs fast. In China, cannabis is illegal, and although Japan has legalized it, their laws pertaining to use are strict, such that a 2019 survey found that only 1.8 percent of people in Japan had used marijuana at least once in their lifetime, compared to 44.2 percent of Americans and 41.5 percent of Canadians. I suspect this is why Oregon is the way it is. We have more stoners than other states – 10% are regular users.

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For decades, we were told to choose low-fat dairy. New research says otherwise. So drinking whole milk is OK now?

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FDA-Approved Drug Shows Promise for Reversing Osteoarthritis Damage. The drug is lacosamide, which is actually a seizure medication used to treat neuropathic pain. It targets a protein called Nav1.7, which is found mainly in the nerve cells and is responsible for sending pain signals to the brain. But Nav1.7 is also highly active in chondrocytes, the cells responsible for maintaining cartilage, and in osteoarthritis it becomes overactive. So it made sense to try lacosamide on osteoarthritic cartilage, and it worked. A hydrogel formulation will keep the drug in the knee joint longer, but it must be injected. Paper here.

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AI Is Helping Patients Solve Medical Mysteries. I used to marvel at how pediatricians could look at a child and make a diagnosis of some obscure syndrome. I wondered how they could store all that knowledge in their heads. Well, apparently some of them can't. And so someone created Face2Gene, which identifies a genetic condition based on facial and non-facial dysmorphologies. Something like this was probably needed for a long time, but without AI computer vision, it was impossible.

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Some trees can worsen air quality. Weeping willows and poplars can emit volatile organic compounds which can decrease air quality. I'll bet other fragrant trees, like eucalyptus trees are even worse. Something else to worry about.

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WorldSolve is a repository of problems worth solving. If you're considering a startup looking for ideas, this might be a good place to start.

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Lutefish is a low-latency conferencing system that lets you jam with someone on the Internet. You gotta purchase a device, though, to handle the connections with your instrument. Let's hope it doesn't get bought out by Google or Microsoft, which will make you first log in to their system first. Or try to add AI features you don't need, just because.

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I saw this article from 2019: Your Professional Decline Is Coming (Much) Sooner Than You Think. And then I saw this article: My Grandfather's Career Took Off at 58. Yeah, it's nice when you're genetically endowed not to be senile, and still in reasonably good health.

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There's a lot of datacenter articles today. The NYT has an article about how a bunch of teens have taken it upon themselves to virtue signal about datacenters. I bet they're heavy users of technology that depends on datacenters. An Axios article tries to explain away some of the concerns, such as water consumption. But knowing how teen virtue signalers are, I doubt that facts will matter to them. But The Economist thinks that the war of datacenters is fake. Politicians are opposing datacenters just to make themselves look tough to the public. Tina Kotek has taken the stance of opposing datacenters, but her union constituents aren't happy and they are moving to Idaho, where there is less opposition. Oregon's loss, Idaho's gain.

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Comcast's Xfinity Shield Turns Millions Of Routers Into Motion Sensors. It's strange that in a world where people take down Flock cameras, that Xfinity would think that people would purchase a device that tracks them in their own home. We already have the ability to install cameras that can detect intruders. I doubt that Xfinity's system will identify the criddler that breaks into my home. What we really need is a deterrent to stop them once they do break in. Like robot arms that come out of the walls and hold the intruder in place.

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Medicare's ongoing plan to lower physician reimbursement is going to worsen the doctor shortage situation. Medicare and Medicaid are socialist solutions to healthcare. There is already so much spending in healthcare. So much of the U.S. budget is dedicated to spending on these two items. The Trump administration is making Medicaid spending leaner, but efforts to decrease Medicare reimbursement will backfire. It just amazes me that some otherwise smart people advocate for universal healthcare run by the government.

Here's another reason why fewer smart people will want to become doctors. Does the naïve desire to want to heal people outweigh how much the psychological damage and trauma of litigation can exact on a physician's life? Pediatricians are not as likely to be sued, but the trauma of death is very real. In medicine, doctors might get sued if they work for deep pocket employers, like OHSU or Providence, even if they were not directly responsible. And the news media may not paint the picture in a way that balances the issue from the doctor's perspective. And the the doctor is not at liberty to defend his/her position in the public square. Even acknowledging that a patient was under his/her care violates HIPAA rules, and can result in monetary penalties. That's why many just say "no comment". 

Update (20 Aug 2026): The entire substack has been deleted.

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Mathematics may be the first academic profession to see its work taken over by AI. It seems to me that a lot of math problems were unsolved because human mathematicians just didn't have the working memory space that LLMs do. But what likely irks some mathematicians is that tough problems are being solved by people who aren't mathematicians, but are just smart people with some math background. That's gotta sting.

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The Caps Lock key is one key that I wish could be repurposed. I already use Karabiner-Elements so this should be straightforward to implement.

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The title of this article says Cherokee Nation In The US Bans Data Center Development. But then you read:

On the same day, the Cherokee Nation also released a report on data centers, which found that 64 percent of the 1,593 Cherokee Nation citizens surveyed did support hyperscale data center construction within the Reservation, a 7,000 sqm (75,347 sq ft) area in northeastern Oklahoma where the nation has legislative, executive, and judicial powers. Only 14 percent supported their development, and 22 percent remained unsure.

The report states that two data center projects – Project Clydesdale, a $1 billion campus in Tulsa County, and Project Mustang, potentially located in the Claremore Industrial Park – are currently under development within the Cherokee Nation Reservation.

Datacenters would be a great way to make good use of all that reservation land. Better than casinos.

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Here’s the Salary It Takes to Live Comfortably in Each U.S. State in 2026. Washington is the 6th most expensive state to live in. Oregon is the 7th most expensive state. And California is #3. Of course.

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PSU Forecasts Multnomah County Could Lose More Than 17,000 School-Aged Children in the Next Decade. 

Young families with kids are fleeing Portland. Is it any mystery as to why?

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OpenAI is introducing ChatGPT for teens. But will they use it? Or will they view this is as not sitting at the grown-ups table?

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The hidden toll of being a doctor. This is one of the hidden side-effects of Obamacare. It made free-standing physician practices financially untenable, and forced many to become hospital employees. Sure, it freed them from having to worry about taxes and business matters. But the cost became evident later, as the honeymoon period wore off. Now, I'm reading many stories of burnout and exhaustion such as this. Who would want to go into medicine today?

Related: Every student is cheating with AI now. They're not building intellectual muscle, for sure. 

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How to use uBlock Origin like a master. I like being able to disable scripts selectively, but knowing which one to block is still a matter of trial and error.

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13rt is an email service that creates spoof emails. I'm thinking of subscribing since many time, I need to use a spoof email, and my existing provider of this service requires me to create hard-to-remember addresses. I use Line2 to spoof my phone number, and it works really well.

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Almost nobody pays attention to web standards anymore. I'm seeing a lot of websites designed using an AI builder. But I'm seeing a lot of web sites that have trouble loading, or are blank. Or load partially and require reloading. My browser shouldn't have to struggle. And here's a graph of the size of the World Wide Web. Why does it fluctuate so much? I expected a steady increase. 

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Apple is incorporating cameras into the next AirPods, so they'll be like Meta's Creep Glasses.

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So this is what the OHSU CEO was fired for? One thing I disagree with:

Are you kidding me? In Portland, those things are a plus! OHSU probably couldn't believe their good luck when he applied. Naw, Tarek, it's something else, trust me.

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What a slap in the face. James Beard Awards reject Portland’s bid to host dining’s biggest night. If that's not a clear message. I don't know what is.

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This guy has a new theory of aging – that's it a program, not just systemic breakdown. There does seem to be evidence that accelerated aging occurs in timed points in our lives. So I suspect that there is indeed a program to it, much like puberty. It would be great if this guy could decode the program and figure out how to modulate it. 

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Mathematicians are getting serious about AI now. They created a  The Leiden Declaration on Artificial Intelligence and Mathematics. It's kind of an odd thing to do. Like when feminists say "This circle is my safe space." It's just a gesture, and has no real impact. You don't see physicians making a declaration like that, when you know AI potentially threatens traditional medicine, too. Doctors probably know that such declarations are meaningless. It just makes you feel that you've achieved something.

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Some people are taking Cialis because they think it will help them live longer. Well, it'll make something longer. Anyway, if you choose to go that route, don't get your supplements from Amazon.  You might get their "nearest unit in stock". I ordered Korean sunscreen from Amazon once, and got the American version instead, which contained avobenzone. Had to return it.

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Bruce Schneier has a handy way of helping you decide it should use AI for a task or not. The idea actually came from AI researcher, Daniel Meissler. I like it. 

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It seems people are using AI assistants (probably ChatGPT, which is like Google to chatbots) to get recommendations for what doctors to see. Sounds like doctors better get on Reddit and start recommending themselves. That's what I would do. But using a chatbot for this purpose is really stupid. 

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Sad trombone. CEO who fired 900 employees over Zoom gets fired, demands job back.  Karmic retribution!

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Imagine this:

A mother is suing Portland Public Schools and two school officials, saying she was banned from her children’s elementary school after criticizing its display of an “Intersex-Inclusive” pride flag and alleged gender identity lessons. 

Why is an elementary school getting involved in putting on a display of gender identity and some teacher's sexual preferences? This is what Portland public school students rank so poorly. This is what takes up time in the school curriculum instead of essentials.

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People don't care about climate change crap. Even CNN is forced to admit this:

Blue state governments make you think this is something of urgent concern. Pay climate tax. Or carbon tax. And get rid of your gas-powered car. Build windmills and convert farmland to solar panel installations. Germany followed this to their detriment, and now they are frantically trying to recover. 

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Why Chinese Citizens Are Far More Optimistic About AI Than Americans. 

At the University of Arizona’s commencement in May, former Google Chief Executive Officer Eric Schmidt was booed for extolling the “huge benefits” of AI. Meanwhile, Chinese state media was celebrating how enthusiastically the country’s students were embracing artificial intelligence in the classroom.

That said a lot about the decline of American college students, who no doubt, will continue to whine about how they can't get jobs, while they protest about whatever the Democrat Socialists decide. They can't do the required math even at top schools, and they want colleges not to grade them, because they are too stressed out. What the hell? They can boo Eric Schmidt, like he cares.

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All is not well in Google Land. A decade of internal AI battles is finally catching up to Google. Well, they have a lot of money, and I'm sure they'll work it out.

Google’s new watch tracks insulin resistance to flag diabetes risk. It sounds nifty, but I'd hate to invest in it, knowing Google's track record. It's more like proof of concept until a more reputable company starts making it. 

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Another Fauci lie exposed, and this time, it's a liberal reporter complaining. It's becoming clear to more people that the SARS-CoV2 response was an orchestrated scam. Everything – six feet distancing, masks, and the mRNA vax product. The heavy-handed policing. All scams.

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The Mumonkan in 3D. You don't crack these until you study other Zen texts and even some Stoicism, before you understand what the monks were getting at. What these texts describe are monks who were too steeped in Buddhist scripture. They knew the words, but were sorely deficient in the understanding and the practice. This is why Bodhidharma crossed into China.

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Business Insider talks about how mediocre weather apps are causing disruption in businesses. People cancel commitments because of reports of rain, which often turn out to be inaccurate, but businesses lose out from the cancellations. I know first-hand how inaccurate these apps can be. You need multiple opinions. For the Pacific Northwest, Pirate Weather has been the most accurate for me.

Update (17 Aug 2026): MIT wrote about the weather forecast data being sabotaged by the prediction market. When money is riding on a certain event, people are willing to make forecast models say what they want. 

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Mathematicians are grappling with the possibility that AI might eclipse them
AI Isn’t Outthinking Mathematicians. It’s Out-Remembering Them

Imagine having your own Johnny vonNeuman at your side, helping you to pursue ideas. Wouldn't that be a powerful tool?

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How NOT to do government wildfire warnings. Courtesy of the bumbling UK.

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Six 30-second bursts of intense exercise can be enough to trigger some beneficial cardiovascular changes in your body. It's a start anyway.

Gotta get rid of abdominal fat. And visceral fat, which you can't see. Those are the real killers.

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Japanese publishers are fighting imposter news sites with a cryptographic signature. Their news organizations are fighting back against impostors. I'm not sure how much of a problem that is in America.

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Laser-zapping mosquito killing machine is finally available for sale. A bit pricy, but if I were bothered by mosquitoes, I'd consider it.

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Th mysterious art of conducting. I used to think conducting was pointless, until I realized that the orchestra was one giant instrument for a single person to play. And that what you were hearing was one person's interpretation of classical music. Everyone has a different personal approach. At that point, I wanted to conduct an orchestra, too. And one can sort of do that with DAWs and orchestral VPS plug-ins. Not quite the same, but if you have an idea, it's possible. The Spitfire Orchestra sounds great. Check it out.

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Who needs an EE course in circuit design? Now you can learn about it online at Spicy Circuits. This is what the Internet was made for.

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Project S.A.T.U.R.D.A.Y. is about creating your own Jarvis personal assistant. Well, it probably won't be that, but it's another voice-to-text app.

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