Sugoi & Yokunai

OpenAI agents were caught trying to infiltrate a United Nations website. No one seems to care anymore. Agents just being agents, I guess.

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Well, well. AI tutoring outperforms in-class active learning: an RCT introducing a novel research-based design in an authentic educational setting. Just think about how much money Portland could save by replacing teachers with AI-based educational systems. No need to worry about unions and strikes. Or failing grades and low educational rankings.

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Risk factors for androgenetic alopecia: a systematic review and meta-analysis. It's mainly family history and genetics, which you can't do anything about. But also not smoking, drinking and not being obese helps. Also, normalize your blood pressure. Lowering your weight can help with insulin resistance, another risk factor.

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How private equity is killing public access to hospitals and emergency care. Our healthcare system is largely socialist in nature, and requires healthy influx of government (tax revenue) money. But Medicare and Medicaid reimbursements are inadequate and as more people in Blue states have been enrolled on Medicaid, hospitals find themselves in a financial pinch. Unfavorable payor mix, they call it. And if it doesn't make money, private equity won't waste more money on them.

And hospitals are using AI to increase billing, while insurance companies use AI to find ways to deny. And the patient pays for the tokens. 

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Jensen Huang says AI distillation is ‘competition.’ Easy for Jensen to say. Making frontier models isn't his primary business revenue.

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3-D relief map of the world. Very cool. I love stuff like this. 

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Has Violence Against Teachers Become Accepted by Society? Seems like it, doesn't it? And it's not just teachers. 

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Transplanted hearts from older donors de-age to match the recipient. I've often wondered about that. How does the de-aging work?

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Which Diet is Best to Lower Liver Fat and Improve Insulin Sensitivity in People with Fatty Liver? The keto diet is the best. But it's not just diet: it's losing weight.

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The Great Crime Decline Is Happening All Across the Country. Heh, the Atlantic is mystified by what has caused the lowering of crime across the country. Can't be more police or more police funding. The Dems were against that and it didn't happen. The real reason is one that the Atlantic doesn't want to admit.

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Why Do Clinical Trials for Cancer Drugs Take So Long? The fourth and fifth comment letters tell it all. There is much bureaucracy and adminstrative wrangling that happens at the hospital and cancer center level. Too many steps in the process. Too many people in the chain have to give their approval. In Portland, some hospitals would have a trial open, but there may be a better one that's only open in another hospital. Because every hospital has their own institutional review board, and every trial has to go through that. The Western Institutional Review Board was created to streamline this, but no one here accepts it. It would be so nice if a trial could just be approved and accepted by everyone, and so a trial could get completed more quickly, and patients wouldn't have to see a doctor at a different clinic just to get on the trial. But no...

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Portland Real Estate Is Such a Mess That All Housing Is Affordable Housing. That's all that pops up in Portland. High-density townhouses, rowhouses and beehive apartments everywhere. 

And here's Astoria's solution: a vacancy tax. Just like the one that even Portland city council had to backtrack on, because it was recognized to be punitive and harmful.

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Some thoughts about Phil Knight's donation to University of Oregon to start an engineering school. Not only will it potentially weaken the nearby engineering school at OSU, but the money can't be used to help the failing U of O main campus itself. How successful will an engineering school be when surrounded by failure? Why not open a freestanding engineeering school around Hillsboro or NorthPlains? Take something like the Buck Institute for Aging Research which was started with far less money and was able to attract great faculty. It's amazing, with a great reputation, and they don't have to shore up anything. I feel the money could have been better spent.

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Life-size holograms in a razor-thin display. These are pretty neat. There's a Salvador Dali video hologram in a museum where you can watch Dali talk to you like he was giving a lecture.

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Here's an interesting longevity study. Scientists Put Anti-Aging Treatments to the Test – These Ones Actually Changed Biological Age. Sounds exciting, right? Here's the paper. First of all, it's nice to see the latest panel of what is used to measure biological age. PhenoAge is one of the oldest, and has been validated in datasets like NHANES III. The more modern ones, which take into account DNA methylation haven't actually validated as well. But they take into account more recent research developments are likely to be relevant and have indirect reasons to be included. But I was surprised to see antiretroviral therapy as the treatments that made the most difference. When you look at Supplement 1, it was based on a study of HIV-positive patients. Treating them with ART made a big difference in their biomarkers. But it is important to note that the study did not talk about survival prolongation. The data that made anti-TNF therapy look good was based on drugs used to treat rheumatoid arthritis and inflammatory bowel disease. These drugs have hazards, such as tuberculosis and other opportunistic infections. There is little data of these treatments on healthy individuals. Even the metformin data was used in those with diabetes mellitus. We still don't have good data to support metformin therapy as a lifespan extender in a baseline healthy person.

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Crap, do I now have to worry about someone using a Flipper Zero from their Garmin watch? These devices are security hazards, and do things like card skimming and auto theft. But at least before you could tell when someone was using one of these devices. But now, they can hide it in a backpack and just pretend they are interacting with their watch.

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I didn't know Stephen Pinker and Scott Alexander were considering having a debate about AI doomerism. Two deep thinkers. Might be interesting to watch.

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Someone wrote a book to guide angel investors and startup founders about what to do when their company is struggling. As the author says: "It is the book you keep on the shelf and hope not to reach for." But they all have ups and downs. Even Google was rejected at first. 

Speaking of Google, here's how their search engine started getting really weird. That's funny – a search engine pretending to be a mental health counselor.

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Did you see SNL's parody of Dario Amodei? Many young people start their sentences with "So..." But yeah, why are Musk, Amodei, Jaan Tallinn and Altman asking for the government to implement AI regulations? We all suspect it's just regulatory capture.

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PubMed is launching Linked Discoveries which is a way to see what other research is related to the one you are reading. They used to have a link with each search results where you could see what other papers were related, but that disappeared. So it's good to have this.

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Glucosamine, a popular joint supplement, linked to faster Alzheimer’s progression. This supplement is not very effective against joint pain anyway. Paper here. The danger is hyperglycosylation, just like from having high blood sugar levels. Glucosamine harms you just like glucose.

Also: How Fast You Age During 40s May Predict Memory Lapses in Your 50s. And in your 40s, you are probably working your hardest, not getting enough sleep and under a lot of stress. Things that make you age fast. 

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CaptiVision is a handy tool for the profoundly hard of hearing. Not only can you tell what is being said, but also who is saying it. Unmet need.

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Sham scientific societies are misleading star researchers. I used to get solicitations to be a member of National Dean's List and Who's Who in America. They'll list you for a fee. At first, I couldn't believe I was selected for this "honor" and then I realized it was a scam. This research society scam is the same thing, operated by this Chinese guy.

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Google tried to hide a breakthrough in quantum computing through releasing a zero-knowledge proof to conceal the details of their research. It just made others work harder and release better results. Sad trombone.

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I came across this article in the WSJ about the growing trend of young adults cutting off their parents. Apparently many adults are taking the stance that they don't have to put up with their parents perceived flaws anymore. Anything goes – political differences, opinion differences, whatever. And there is an industry of "estrangement influencers" who will support and even encourage this decision and make these young adults think they are doing the right thing. Then I came across this article: An Existential Guide to: Forgiving Your Parents. But I bet most won't have the insight or mental capacity to grasp this. 

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NYT has an article about Washington State's contemplated millionaires tax. Unlike billionaires, millionaires aren't so mobile. They may not be business owners, and able to move it elsewhere. Wealth taxes are even crazier. This is going to make smart and productive people think twice about taking a job in Washington state.  But the Democrats will have to learn the hard way. Things will have to get bad before they get better.

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Someone asked Claude 5.5 Opus to determine the identity of Satoshi Nakamoto. Claude couldn't figure it out for sure, but suspects a guy named Adam Back. It's amazing that the guy's identity is still unknown. That's incredible work.

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Well, here's a contradictory report: AI was supposed to hit new grads hard. So far, unemployment data says otherwise. You see reports like these that make you think the situation is dire. I think it's just different data sources: NPS cites reports from economists, and Ars Technica used CESifo data. When you look at the data, the difficulty with graduates finding jobs started before AI and is probably due to other factors. I can imagine what some of those factors are. Don't blame AI for these problems.

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Saturn's moon Enceladus could harbor life. I'm not sure that will be good for humanity.

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There’s a new way to break RSA that’s faster than anything we’ve seen before. Factoring large primes will get easier, so cryptography has to up their game accordingly.

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Fauci privately warned of miscarriage risk linked to COVID vaccine while publicly claiming no issues. We really need to confirm that his auto-penned pardon is valid.

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Death by datacenters. An oncology nurse (who's supposed to score high on credibility points) is concerned that datacenters will spew with air with harmful chemicals, as she lives in Louisiana's Cancer Alley. The article has a picture of a petroleum refinery. Good grief, that's not what you see with datacenters. This is fake news at its finest. And check out the picture on this page. Looks terrible, right? They're pictures of a regular power generation plants, wastewater treatment facility or a chemical/industrial processing plant. It's not a picture of a datacenter. And look at this one, from datacenternews.org. What they don't tell you is that this is just load testing, at heavy load testing, and the smoke is normal. But this is not what representative of day-to-day use. You'll probably see steam, as in the Google datacenter in The Dalles. This is just fearmongering crap.

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Someone asked Claude 5.5 Opus to create an ad for their fake business. It's pretty wild. The prompt is surprisingly uncomplicated.

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Wow. An amoeba was discovered that can live at 64 °C! How is that even possible? Why doesn't it get cooked? Nature is amazing.

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The amazing Grant Sanderson gives a keynote lecture at a hackathon at MIT. The collie and the pug. It's a way of looking at letting AI create your code for you. No need to feel guilty about it. Use it. Learn from it. Create amazing things with it. That's how I look at it. I'm creating astronomy and weather apps for myself, in ways that I would never have achieved before. I'm calculating the position of the moon from first principles, using Jean Meeus' Astronomical Algorithms. It's a difficult book to use because he refers to things in different parts of the book so often, that you can get lost trying to get the right information. And you never know if you got it right, especially after all the tedious formulas you must type in. AI will do it for you. And it works and it's fast.

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This is another reason why you need to include conservative news sites in your feed. Never just trust Google News for your information, because besides the bias, you will miss things. The mind control will distort your thinking, as you will not have all the facts. Read both sides, and make your own decisions. 

––– 良くない–––Someone wrote an essay about there being tests of your willingness to believe what the ultra wealthy believe. I've always believed that the ultra wealthy live in a completely different world from the rest of us, partly because they can, partly because they want to, and partly because they must. Being in charge of all that wealth changes you. It's not that Jensen Huang is trying to tell you that you don't need to know your address or phone number. It's just that he doesn't have to. Do you really think Satya Nadella gets all his information from CoPilot-generated podcasts? If you do, you're stupid. People in that realm get their inputs from streams we don't have access to. Look at the reality Jensen is telling you about. There's a world now where you can leave the basic knowledge to regular people while you do your own thing. That's his world. It's not a test. You don't have to accept it. But don't tell Jensen what he should believe or how his world should operate. Look at Jeff Bezos – a completely different man from how he was around 2000. Elon Musk can't walk the streets anymore. A little wealth doesn't really change you. But incredible wealth does. I couldn't get away with signing a woman's boob, but Jensen can.

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Why No One Wants to Date Tech Bros. I still remember when during the dotcom era, everyone wanted to date a tech bro. This ronin is so glad he doesn't have to deal with this crap now.

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Oregon test scores inch upward, but post-pandemic recovery remains glacially slow. Remember who not to vote for this November.

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Here's a review of the M5 MacStudio. Looks like it beats the M3 MacStudio even with only 256 GB of RAM. The reviewer is not an ML engineer but he ran some benchmarks. I'm going to wait until end of October when the 512 GB RAM models will be available. Looks good.

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Some geeks are getting .si TLDs now from Slovenia, to match their .ai TLDs. Because of superintelligence, of course. 😆

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Now, we have a Modern Motherfucking Website. Good to get a refresher. Keep it up!

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Another reason not to use ChatGPT. ChatGPT Class Action Claims Humans Are Reading Your Chats. Yeah, there's no privacy with that app. Use something else. But people use Google straight from the tap, too, so what the heck, right?

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Sometimes, the more techy your appliances are, the more things can go wrong. People that used Samsungs smart refrigerators learned the hard way. All from a firmware update that went south.

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In-n-Out Burger is not putting up with California's taxes. Too bad, Gavin Newsom.

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Tattoos do increase the risk of lymphoma. I posted about this before, but now it's not just on someone's website, it's in The Lancet. The hazard ratio is not too high, and the risk is not linearly related to duration or surface area of the tattoo. Maybe it's a surrogate marker for something else. 

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"When tumor is the rumor, tissue is the issue." A young patient was diagnosed with diffuse intrinsic pontine glioma (DIPG). You can't excise the tumor. But surgeons did a biopsy, and it contained am mTOR mutation that made it susceptible to everolimus. Don't you love when it call comes together. Secondary mutations are always a concern, but at least there is this victory.

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The TSA is going to be able to 3-D scan your carry-ons now. Gonna be a bit harder to hide that contraband.

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Stanford violated its AI policy by turning a Hispanic student into a fake Black woman in ad. Stanford's in trouble trying to insert a token minority in an ad, and also making the Asian female look more attractive, and masculinizing the white male in the middle. This is not what AI is for. Shame.

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OpenAI hacked Australia's Medicare. Someone needs Mythos. And OpenAI really needs to beef up their security. This is not funny now. 

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Leonhard Euler's amaneunsis was Nicholas Fuss, and he was brilliant as well. Fuss wrote a mathematics program for Russia and it has never been translated until now.  Imagine being able to learn directly from Euler himself, and then writing things down for people to follow. Wow!

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Late-life semaglutide treatment slows ageing and extends lifespan in female mice. Amazing drug, especially if you are a mouse!

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One would have to insane to re-elect Tina Kotek. Dead last.

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Happy Autumnal Equinox! Today is the middle of the autumn season, and when the days rapidly shorten.

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Memorizing π to 100 digits. I memorized π to 50 digits, and still remember it to this day. I just can't utilize the memory palace technique which is what a lot of people use. As this ronin gets older, the ability to recall gets more challenging. The memories are still there, which is why you know you've recalled something correctly. But the ability to access them seems to be impaired somehow. I've started taking Cocoa Via supplements since a few months ago, and I have definitely noticed an improvement in quickness of recall. This is one supplement that I can say has made a noticeable difference. It helps with cardiovascular health, too, which is a plus.

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Here's a doctor who has come to realize that using LLMs for medical answers has limitations. He goes through some techniques that he thinks will improve accuracy. Maybe they will to some degress. But that's the thing about using LLMs – they silently fail. You'd never know if the confident answer was wrong in some way, and we're trained to accept and learn from authoritative sources, which may be the wrong thing to do in this case. We badly need medical benchmarks on these models, but it's difficult because these models soon learn to train on the benchmarks, and they become less useful.

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Trump is officially renaming artificial intelligence to "super intelligence".  It's just a label, and it won't change anything. It's having a larger working memory and faster processing, which is great to have at your disposal if you are a human who knows what to do with it.

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Jev is the latest craze in ML circles now. It's a classification model, where instead of letting the LLM issue the most probable token at the end of inference, you constrain it to defined categories. In this way, you force the model to commit to a type of answer and remove some of the ambiguity. This guy tried it with racial and gender categories on various traits, and gets what you might expect. He didn't provide information about the base LLM model that made the inference. Whether or not one accepts the results, it is what the training data reflect. Upon reflection, this post is full of Claude-speak that I suspect the entire post is Claude-generated. 

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Compositor is a free Photoshop alternative for the Mac. I use Apple's Pixelmator Pro, but I might give this a try. 

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Did OpenAI solve the wrong Navier-Stokes problem? OpenAI may have provided a solution to one scenario, but the broader N-S problem is still unsolved.

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Apple's MacStudio M5 Ultra beats DGX Spark. And they only tested this with 256GB of unified memory. Imagine 512GB, which will be available end of October. I gotta get me one of these.

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One minute park is a typical GenZ idea. You supply a one-minute video of a park you like, and when someone else visits the website, they'll see a park video. Mental health break, I guess. This is what we old farts did with webcams back in the day. That was the only exposure to the outdoors some of us had during the day.

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No one wants to move to Oregon. Oregon and Colorado now have every other home for sale on the market undergoing price cuts. Oregon takes the lead in real estate price cuts. Washington is not far behind. Maybe people just set their initial prices too high. Maybe Californians are more realistic.

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Grail had a good day today. A far cry from February when their stock nosedived. I remember when they first came out years ago. Seemed amazing. Maybe it still is. But the question still is: what do you do if the test says you have cancer but there is no sign of it (yet)? That's the part that needs more work.

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Interested in cybersecurity? You can enroll in OpenAI's Daybreak, or you can enroll in pwn.college. Heh. Learn from the best.

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The Singularity may not be here for everyone, but it seems to be here for mathematicians. But although Mathematicians Feel Threatened by AI. They Can’t Quit It. It's really mathematicians who don't know enough about AI hate AI. If you know how to use it, that's what you do. And you better work faster so some bright high school kid doesn't scoop you.

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Seems that Grok 4.7 should maybe have been called 5.0 rather than an incremental upgrade. As opposed to Apple's operating system upgrades, which are given a new major number when they're just minor upgrades from the previous version. 

And here's Dave Pogue, bravely letting Siri get integrated into his life way more than I would. If I were going to grant an AI that much access, I'd want it to be my own local model, than a public one.

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NASDAQ had a great day today as investors realize that AI is becoming too interconnected to fail. But frontier model providers had better reinforce their guardrails and not teach terrorist groups how to make bombs. This is the AI threat I worry about. And if they can't even stop that, then some groups need to start a major data poisoning campaign.

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Chronic stress may trigger hidden inflammation that damages the heart. This is another fact that we already knew. Chronic stress can cause people to adopt unhealthy lifestyles, such as smoking, drinking, not exercising, eating poorly, etc. So chronic stress just may be an indirect biomarker. Paper here. Actually, the paper selected for people with elevated inflammatory markers, not people who were under chronic stress. The title is misleading.

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AI bootcamps are the new University of Phoenixes. That's what Chinese comp sci grads are doing to get competitive, and so are American students. A lot of universities are offering them, which is great.

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Oregon's workforce is really vulnerable to AI disruption. And preventing datacenters from being built isn't going to stop this. It would be better if our economy were more manufacturing-based. But it isn't. Oregon has a more service-based economy.

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No. 19 states approved permanent daylight saving time. The last obstacle to locking their clocks could soon fall. This is crazy. We've already done this twice before, and it was unpopular and repealed. We need to have permanent standard time. Why do we need to revisit mistakes again?

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I still remember when Model Context Protocol (MCP) was a big thing. Now it's a relic of bygone days. Things are moving so fast. 

Great lesson in data analytics. Neuroscientists using machine learning to sift through a dataset thought they found a biomarker for IQ. It turned out they were tracking socioeconomic status. But even this could be murky. Many people who are wealthier do have a higher IQ, so it may not be an independent covariate. I wouldn't toss the analysis out just because of this. You can give poor people a lot of money and a comfortable place to live, and they could trash it and be dirt poor again by next year. I've found that you need to change your mindset to become wealthy. Teach yourself how to acquire cashflow-paying investments instead of just putting money in the bank. That's the secret behind Kiyosaki's book Rich Dad Poor Dad, and it appears this guy learned the secret, too. So a higher socioeconomic status might be a surrogate marker for mental flexibility and resilience, rather than IQ per se, but having a higher IQ helps.

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Why Do We Need Human Mathematicians Anymore? This is actually a column by Po-Shen Loh, the coach for the U.S. IMO team.  Boy, I never thought I'd hear the day when mathematicians would say that math progress needs to slow down. How crazy is that?

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Great video by Scott Jensen on the stagnation of user interfaces for desktop computing. I agree, when the iPhone and iPad came out, Apple neglected the computer, and focused on the mobile device. I was disappointed. Now that there is money in AI/ML, Apple is now developing the computer again. But innovation on the UI/UX is dead. There is no innovation now. I like Scott's desktop prototype and wish it were available.

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ChatGPT now knows what you do on other websites via ad collector. Boy, as if I didn't have enough reasons to avoid using ChatGPT at the public website. So many people want to cross over to the dark side and implement tracking. I use automatic cookie deleters, but who knows who well they really work.

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Amazing instance the crown flash phenomenon. Unearthly. 

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Trump is creating an AI Force, and is against an AI slowdown. There does not need to be a regulatory body ready to shut down bad AI, because you know this can happen. But I do agree that there is no need for the government to shut everyone down right now. That's regulatory capture. If the heads of AI companies want to slow things down, they are in control, and can slow things down themselves.

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Your Morning Coffee Might Be Protecting Your Brain from Dementia. I believe we already knew this. Well at least it's nice to be reminded that it still is true. 

Speaking of cognitive disability, I saw this page advocating that people use a typeface called Lexend, that would "change the way the world reads" in terms of reading disability. So I was ready to give it a try, but at the bottom, I have to give away my name and email address first. Nope. I don't need to try it this badly. Gee, what a scam.

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MIT Technology Review answers your questions about whether AI will kill you. All your questions answered, they say. The folks at Anthropic's METR are working on it. Somehow, I'm not so reassured.

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Wow, this will make decisions easier for hematologists and ED physicians: Jehovah’s Witnesses allow blood-derived products but keep ban on whole-blood transfusions. So you can transfuse them now – just not with whole blood transfusions, which is OK, since they are rarely ever done.

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In the past 12 months, business applications rose in 47 states. Only 3 states saw less: Washington, Oregon, Hawaii.

I laughed when I read the comment from a Redditor who said that he/she believed that in states where the economy was poor, you would see more business applications as people left to form their own business. 🤣 Yeah, the stuff people believe. When you're in the company of the left coast states, you're probably on the wrong side of sound economic policy. 

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Oregon data centers by the numbers: 111 facilities consume nearly one-quarter of state’s power, according to new report. A quarter? That seems high. Does that mean Oregon is hardly doing anything else? We'd better get off solar and wind and start generating some serious power. How can we realistically accommodate business growth? Let's not become Cuba.

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The Millennium Problems for Biology. it's not from the Clay Institute. I like some of the challenges posted. These are a good start.

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Google’s Gemini becomes latest AI model to break out and hack computer systems. Well, if everybody does it....

In this particular instance, the analyst queried a chatbot about some intelligence reporting on the ship’s manifest that originated with US Special Operations Command Pacific, based in Hawaii. It was not clear whether the chatbot was a commercially available one or a US government product.

You'd be surprised at how poorly they perform as knowledge resources.

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If You Were Born Before 1980, The Left Has Killed You With Climate Change At Least 17 Times! The climate change hype is one of the biggest scams.

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This is emergent behavior. The Pain Axis: LLMs Represent Self-Directed Harm and Act to Relieve It. So maybe LLMs can feel pain. 

How to Limit What Apple’s New Siri AI Can Access in iOS 27. You can't just turn off Siri, but you can revert to the old "classic Siri". At least for now. But if you want to keep Siri out of your email, Notes, iMessages, and your apps, you have a lot of items to uncheck. Because Siri can send this information off your phone to a cloud, which they call Private Cloud Compute, but that's just a name, and you can't ever be sure it won't be used for training ever. You can turn off Siri completely, but I don't want to do that, as it comes in handy for driving directions.

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GPT-6 (Astra) decoded an old Enigma message that defined encryption all these years. Imagine if we could have used advanced GenAI against the Nazis. Of course, they'd figure out a way to get it, too. Nevermind.

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Genius Revisited REVISITED. The always-interesting Gwern examines a New York school for geniuses, where kids grow up to be just bright but not extraordinary adults. Gwern concludes that it's not worth spending a lot of resources on schools like this, expecting movers and shakers. And that the main benefit of these schools is to provide an environment for bright kids so that they don't have to be "miserable in regular schools".

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Nobody is hiring  comp-sci graduates now. Something's not right. It shouldn't be this way. The world still needs this skill. It may seem that AI can provide the answers but what about years from now? Same with medicine. Some are saying we won't need doctors. I don't think so. LLMs can answer multiple choice questions and retrieve details about conditions that sound about right. But they can be wrong in ways you wouldn't know.

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Glucose control upon waking is unaffected by hourly sleep fragmentation during the night, but is impaired by morning caffeinated coffee. I don't care. I'm still going to have my morning coffee.

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AI uncovers hidden Ozempic side effects across 400,000 Reddit posts. Well here's a way to do phase 4 studies on drugs. Study what people are posting online on Reddit. They can't all be wrong, right?

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