The 48-Hour Cancer Binder. This post is both a fascinating inside look at how to use ML tools to design targeted drugs – a must read for anyone looking into pursuing this field. But it's also a great insight into organizing a hackathon team, divvying up tasks based on domain expertise, and working together to achieve the design goal. A major part of success is being able to present your idea effectively, creating a great pitch. Apparently, not doing so is why these guys didn't win.
BTW, there already is a drug that targets the FGFR receptor, erdafitinib, used for urothelial cancer, and I suspect it was designed in a similar way.
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BTW, there already is a drug that targets the FGFR receptor, erdafitinib, used for urothelial cancer, and I suspect it was designed in a similar way.
Apparently working for Meta is a horror-show. I remember when working there was prestigious. Now, it's a nightmare.
Speaking of fear and horror, I just read about this condition (Urbach-Wiethe syndrome) where your amygdala gets inactivated by progressive calcification. You live without fear. Much of meditation and stress reduction techniques is training to learn to control signals from the amygdala. We need to have a little bit of fear, but in some cases, it can get in the way.
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This makes no sense. India Missed Out on AI and Now Its Run as Market Darling May Be Over. It seems like 80% of the AI articles, podcasts and YT videos are by Indians. Many workers in tech are Indians. How could they miss out on AI? They practically developed AI! Did all the graduates of IIT leave the country? How did their business leaders let this happen?
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It's true. Google Maps no longer shows the destruction that happened after the massive Pacific Palisades fire. Check it out. It's like it never happened. Lahaina, on the other hand, shows the aftermath. Why did Google choose to revert back? Very strange.
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Here's a fascinating look at how the New Testament changed as it was copied over and over throughout the centuries. Imagine being tasked to copy that book by hand.
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Why birth rates are falling everywhere all at once. This theory posits that:
But the data shows that across broader society, the number of people finding partners and having children is declining despite intentions. This is notably pronounced among the least well off, and accompanies mounting loneliness and dating frustrations.So when you see what the ideal man or woman is on the Internet, the real life person standing in front of you just doesn't pass muster. You want the unattainable. Anything less just doesn't cut it anymore.
And even when couples can afford to move into their own place, they are increasingly likely to separate. In several countries, people who move in together are now more likely to split up than to have a child, a sharp reversal of the historical norm.
Dissatisfied with purely economic explanations, researchers are beginning to point the finger at a new culprit — the digital devices and platforms that play an outsized role in young people’s lives across the world.
The number of births fell first and fastest in the areas that received high-speed mobile connectivity earliest. The authors argue that smartphones have transformed how young people spend time with one another, sharply reducing in-person socialising and leading to the collapse in their fertility.
In country after country the birth rate plunged after the introduction of smartphones, no matter what the previous trend was. The younger the age group, the more pronounced the downturn — a mirror image of smartphone usage patterns.
“If you spend lots of time socialising with your peers in the real world, your standards [for a potential partner] are anchored in the real world. If you spend your time on Instagram, your standards are anchored to an artificial sense of what is normal.”
A lot of people, it seems, are finding that they have high unauthorized Google API expenses. Even after you set spending caps. Sometimes you find that Google automatically upgraded your tier. How did this come about? Hacking? It's not clear, and Google is trying to sort it out. But it kinda sucks some of the fun out of AI coding, doesn't it?
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Scientists Say They’ve Invented a Serum That Activates a Dormant Ability to Regrow Lost Limbs in Mammals. This was shown in mice, through the sequential application of FGF2 and BMP2. Now do it in humans.
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The search for the next James Bond actor has begun. Not crazy about the candidates listed, but oh well. It should be this AI-generated character.
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University of Washington is going to have a separate graduation ceremony for undocumented students. Of course they will.
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Is downtown Portland on the verge of a comeback? Here’s what locals think. One guy sees the homeless and his "heart breaks for them". He thinks that the reason for the slow decline of the city since 2020 is insufficient housing, and that adding more will drive people to live in the city. Well, Portland’s Housing Authority Sits On 955 Empty Apartments. The number of vacant affordable housing units in Portland reaches 10-year high. The vacancy rate in downtown and SW Portland has increased 28% YoY. There are enough homes – no one wants to move in!!
Sometimes I think that there wouldn't be any progressives if people were just better informed.
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SeaPort airlines offers TSA-free service to Portland, Seattle, Spokane from Redmond. It's like NetJets. Too bad it's located in Redmond, Oregon.
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Seattle considers state of emergency due to all of the 2SLGBTQIA+ refugees from Texas . I thought this was funny. No panic when illegal aliens and foreign TPS holders invade the Pacific NW. But when it comes to LGBTQ, it's suddenly an emergency. "And Texas is happy to have that crowd gone." I'll bet.
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How many government employees does it take to move three homeless people? Kevin Dahlgren exposes the Homeless Industrial Complex. Of course it takes a lot of people. Who will just kick them out and let them relocate somewhere nearby. But hey, the City did something, right? Rinse repeat. This is the HIC. The problem is now so big that it requires organized response, which means more money and people who have jobs to do. Which must be funded by taxpayers. And government grants.
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Sound Transit has a $35 billion funding gap. Dems everywhere love mass transit. They love to build it. Expand it. Even when it doesn't pencil out.
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