Mitochondrial function may be the key to why we sleep.
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So it's all in the mitochondria, then. The paper still doesn't explain the why. Why does this need to happen? Why can't we replenish peroxidized lipids all the time, instead of just while we sleep?Here we report that transcripts upregulated after sleep deprivation, in sleep-control neurons projecting to the dorsal fan-shaped body (dFBNs) but not ubiquitously in the brain, encode almost exclusively proteins with roles in mitochondrial respiration and ATP synthesis. These gene expression changes are accompanied by mitochondrial fragmentation, enhanced mitophagy and an increase in the number of contacts between mitochondria and the endoplasmic reticulum, creating conduits for the replenishment of peroxidized lipids. The morphological changes are reversible after recovery sleep and blunted by the installation of an electron overflow in the respiratory chain.
Sleep, like ageing, may be an inescapable consequence of aerobic metabolism.
Meta has poached two key AI experts from Apple. Why does it have to be Meta? Why couldn't it be some less invasive company? I just don't trust Zuck to own the next generation of AI developments.
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Tirzepatide seems to slow breast cancer growth. Well, since breast cancer growth is associated with obesity, it's not surprising that this happens. Elimination of obesity will likely improve lots of things. Maybe your career, your love life, etc.
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Diamonds are not worth the expense anymore. Even De Beers has thrown in the towel. It was a good run while it lasted. Progress is a good thing, right?
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Scientists are developing a universal cancer vaccine that can kills "any tumor". This seems to be the wrong approach to me. I would rather we figure out how to put multiple copies of the TP53 gene into the genome. Seems to make better sense to me than subverting the immune system to attack some onco-antigen.
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Eating eggs is good for your cholesterol now. It doesn't cause harm like conventional wisdom has said. Nutritional wisdom always seems to change radically every ten years or so. Things that were considered good are now bad, and vice versa.
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Erythritol is now linked to brain injury and strokes. Shouldn't we take this off the market? Are you seeing this, RFK, Jr?
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Space travel can permanently damage your eyesight. There is a condition called Spaceflight Associated Neuro-ocular Syndrome, and it causes edema of the optic nerve, due to microgravity. Once it causes damage, it is irreversible.
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Lost cause. Voice actors demand that AI regulate voice generative AI. Yeah, that's not going to happen. You're not that special, and this is going to go the way of the buggy whip. Sorry, but it was fun while it lasted.
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Most old folks, like this ronin, have a scar on their arm, and we were told it was a smallpox vaccine scar. But wait.
Many foreign-born persons have received the bacille Calmette-Guerin (BCG) vaccine for TB disease. This vaccine is administered at birth in many countries outside of the U.S. to prevent childhood tuberculous meningitis and miliary disease. BCG leaves a scar like the smallpox vaccine. But it doesn’t protect against smallpox.
So if you have a positive TB test, it might be from the BCG you got, not from actual tuberculosis.
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OpenAI has scored well enough on the International Math Olympiad to have won the gold medal. Who needs MIT students anymore, right?
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Why is Oregon still blaming the pandemic for poor school performance? The rest of the country has moved on. Man, the coronavirus epidemic was five years ago. Enough, already. Look in the mirror to see who deserves the blame.
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Portland city government force the Gateway Fred Meyer to close.
Also since last year, Portland went on a property tax increase binge as well as enacted a 10-cent gas tax hike. Just months ago, Portland pushed through a billion dollar property tax hike for schools. Just weeks ago, Portland City Hall jacked up parking fees and doubled the Uber tax.
A full year of non-stop financial blows both from within by workers and from the outside by politicians hurt the Gateway Fred Meyers too much.
Now those union workers don’t have a job.
Good going, folks. The Doom Loop continues.
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