Immunoregulatory role of quercetin in lung cancer. It turns out that quercetin can activate a p53 pathway, and in mice, treatment with quercetin inhibited growth and metastasis of A549 and H520 human lung cancer cell lines, and also altered the gut microbiome. Paper here.
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Incredible. I discovered a sound that leaks your exact location (and it's everywhere. You gotta watch this video. It's amazing. Apparently videos that record sound outdoors will pick up doppler echoes of overhead planes flying. Because flights data are available, it's possible to triangulate from sound propagation equations, where the sound must have been recorded. It's super nerdy but scary what information you can obtain from seemingly prosaic data. There's already a lot of stuff out there about geolocation OSINT (like here, here and here), but I've not seen this before.
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The price of the Marshall Islands’ universal basic income. I came across this article recently, and as a firm believer that UBI can't work, I wanted to know how the Marshall Islands (of all places) made this possible. Apparently, it's been in operation since December 2025! The answer is that they get monetary support from the U.S. government as reparations for the atomic bombing in the South Pacific. Of course! So American taxpayer money goes to paying every Marshall Islander free money. What a deal, eh?
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We gave it 19 gene therapy vectors in a spreadsheet, a mouse model of epilepsy, access to a motorize surgery rig with cameras and one goal: reduce seizures.Weird that this gets published on X instead of a research journal. And soon, there'll be more information on a Substack! AI has changed both math and science – I can't keep up!
It picked the drug. It picked the brain region. It derived the coordinates from three papers. Then it drove the stereotaxic arms into the brain and injected 250 nanolitres while watching the entry site through the rig camera for bleeding.
AI is changing the gaming industry. People are just cloning games instead of buying them. Sounds like the gaming industry is going through the same stages of grief as mathematicians. But unlike the mathematicians, who might be able to stop sharing and restrict collaboration, how do you make money if you stop publicizing your games?
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Binance was hacked for $6.3 billion in assets, and when they allowed withdrawals again, people withdrew $3.6 billion. And the company just shrugs it off. Geez, how much money do these guys have anyway? Turns out they have $171 billion in assets! On the same scale as banks like KeyBank and Barclays US. But Binance's assets are customer crypto holdings, and their asset figure is just self-reported asset snapshots, not through audited controls. The hack is suspected to come from North Korea. Score one for Dear Leader, I guess.
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The scientists found that Hawaii and Easter Island were likely both settled by members of a single "ultravoyager" culture from the Mangareva islands, about 3,440 miles (5,530 km) southeast of Hawaii and 1,600 miles (2,600 km) west of Easter Island.
The ability to sail from one tiny island to another across far reaches has always been an astonishing feat to me. So easy to get lost. And once you're out there, there's no turning back. So what is that genetic advantage that might help in today's society? Is it courage? The incredible self-confidence? Problem-solving skills?
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Six in 10 Americans Uncomfortable With Doctors Using AI for Diagnoses, and Most Want Humans Making Final Calls. Most doctors are already using AI to help them make a diagnosis. Older doctors don't need it, but younger, less confident, doctors will feel that they need AI assistance. The problem is that the tools aren't as good as they seem. I can vouch directly about this. But the more junior you are, you won't know when to push back and recognize biases. But medical knowledge is exploding – who can realistically keep up with it all? And American clinical doctors are increasingly coming from Caribbean medical schools. International medical graduates (IMGs) not born in the U.S. made up 36.1% of the internal medicine workforce in 2026. And IMGs born outside of the U.S. made up at least 27% of the doctors practicing in each internal medicine subspecialty. In Florida, New York, and New Jersey, where IMGs make up close to 40% of the family medicine workforce.
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...earlier cuts to administrative and support staff have forced faculty members to take on extra work. Doctors and other clinicians are spending more time dealing with scheduling problems and paperwork instead of caring for patients,“We are burning out our greatest asset,” she said, adding that some faculty members have already become “disillusioned and disgruntled” or have quit, leaving their colleagues to shoulder even more work.
If you're not a union member, you're probably screwed.
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