Scientists say they’ve reversed brain aging with a simple nasal spray.
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The therapy relies on microscopic biological particles called extracellular vesicles (EVs). These tiny structures naturally transport genetic material between cells. In this case, they were loaded with microRNAs, molecules that help regulate important biological processes in the brain.The secret sauce is in the microRNAs. "According to the researchers, the therapy suppressed inflammatory systems such as the NLRP3 inflammasome and the cGAS-STING signaling pathways, both of which are strongly linked to aging related brain inflammation." Paper here.
"MicroRNAs act like master regulators," Narayana said. "They help modulate and regulate many gene and signaling pathways in the brain."
Researchers delivered the EVs through a nasal spray, allowing the treatment to bypass the brain's protective barrier and travel directly into brain tissue.
Websites have a new way of tracking you. If you surf other websites at the same time, your disk access patterns can give you away. Of course, they all have to use this technique, and there needs to be a central data collection repository for this to be useful.
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Google is losing its core search business. I'm reading about more people switching to Kagi search as well. What about Bing search?
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US law enforcement warns of “anti-tech extremism” as AI hatred grows. America is rapidly becoming a society where violence is acceptable if you disagree with something. Soon, it can be said that a democratic republic is not suitable to govern America.
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WTF?? With dynamic pricing at Walmart, the price of an item can differ depending on where in the store you are standing.
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Dysfunction in a nutshell. Portland leaders launch fast-track renaming of César E. Chávez Boulevard. Why must Portland name a city street after a California labor union leader? Or California farmers? Or anything regarding California? No input from people who live on the street. Breaking their own rules to rush this through.
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Los Angeles mansion tax backfired. LA needs Spencer Pratt so badly. Portland needs to learn from this.
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Seattle Redditors unhappy about EV charging station vandalism. Out of control, they say. But hey, defund the police. Support "harm reduction". And f*ck ICE, who just wants to remove criminals, right?
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