28 November 2025

The Impossible Prompt That's Easy for Humans. This is Moravec's Paradox. Stuff that is easy for a child is too difficult for advanced GenAI. Here's proof.

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Tattoo Ink Moves Through the Body, Killing Immune Cells and Weakening Vaccine Response. Do you know what's even in tattoo ink? Carbon black, polycyclic aromatic hydrocarbons and azo dyes.  
Tattooed participants had higher risks of skin cancers — including melanoma and squamous cell carcinoma — as well as lymphoma, with hazards rising further for tattoos larger than a palm. In one arm of the study, large tattoos were linked to a 2.7-fold higher hazard of lymphoma and more than double the risk of skin cancer.
What's the attraction with tattoos? You'll look like a funny old person, that's for sure.

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Inhibiting a master regulator of aging regenerates joint cartilage in mice. Apparently, blocking the function of 15-PGDH with a small molecule results in an increase in old animals' muscle mass and endurance.  15-PGDH is a gerozyme due to its increase in prevalence as the body ages, and is a master regulator of aging.

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I had been thinking about getting an Oura Ring, especially as it's being sold at Costco. But now, I think not
For the past couple of weeks, there has been an ongoing uproar from Oura customers following the announcement of a partnership between the wearable smart ring maker, and the U.S. Department of War and Palantir. 
...a spokesperson for Oura tells me that the company has received government demands for customers' data.
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Utility rates up 50% in Oregon. Here’s why.  Short answer: datacenters, taxes, and ill-advised investments in renewable energy. Germany is also learning the same painful lesson.

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An important component of this highway is a region in the center of the brain called the thalamus, which not only helps select which memories should be remembered, but routes them to cortex for long-term stabilization.

The model suggests that, after the basic memory is formed in the hippocampus, Camta1 and its targets ensure the initial persistence of the memory. With time, Tcf4 and its targets are activated providing cell adhesion and structural support to further maintain the memory. Finally, Ash1l recruits chromatin remodeling programs that make the memory more persistent.

“Unless you promote memories onto these timers, we believe you’re primed to forget it quickly,” Rajasethupathy says.

The results suggest that long-term memory is not maintained by a single molecular on-and-off switch, but by a cascade of gene-regulating programs that unfold over time and across brain regions like a series of molecular timers.
Interesting that the thalamus is involved. It's central in so many things.

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This is why Portland is a ghost town.
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Dan & Louis Oyster Bar.  Started in 1907. Survived two World Wars. Survived the BLM riots. Survived COVID-19. But now closing because business is too slow.  Good job, Dennis Wilson. Keep littering the city with homeless shelters. We need more because other states are sending their refuse our way. Yup, 75% are imported.  Come to Portland and get a free house. And shoot up all you want.

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Oregon topped the nation in Thanksgiving family arguments.  The state is always #1 for the wrong things, you notice?

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