Drug trio found to block tumour resistance in pancreatic cancer
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A new study reports that a triple-targeted drug combination can drive complete and lasting regression of pancreatic tumours in preclinical models, potentially overcoming treatment resistance in one of the deadliest cancers.
Researchers at the Spanish National Cancer Research Centre have announced a potential breakthrough combination therapy that induces complete regression of pancreatic tumours and prevents tumour resistance in preclinical models.
Paper here. The drugs they used were:
- RMC-6236 (daraxonrasib): targeting KRAS
- Afatinib: an EGFR family inhibitor
- SD36: a selective STAT3 degrader
Freakpages. Where you get to learn about stuff that you see mentioned in blog posts about that you're supposed to know.
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Google is getting into the world-building business, too, with Genie 3.
Mozilla is going to do something in the AI realm. "...a bunch of people are banding together to create something good in the world and take on this thing that threatens us.” “It’s super corny, but people totally get it.” What it is that they plan to do is not clear. But they plan to take on OpenAI and other big players. Somehow, I don't think those guys are worried.
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Picify is trying to be a scaled-down Photoshop for people who don't need the full package. I'll bookmark it and maybe try it out someday. (I'm frequently disappointed by these efforts, so we'll see.)
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A treatment for male-pattern baldness? Polygonum multiflorum, also known as Polygoni multiflori radix (PMT) or He Shou Wu, is a root used in traditional Chinese medicine for more than a thousand years. It may be effective against male-pattern baldness. If it were that effective, why do I still see a lot of bald Chinese men?
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Smart Quotes for Smart People. Everything you wanted to know about them. Yeah, they look nice, but they are always gumming up my RSS readers, who don't know how to interpret them, and so they flag an error, and my feed is declared invalid. So for my RSS feeds, I convert them all to dumb quotes, so I can at least read something.
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This is a great essay: A Nation of Laws...or Leftists? There's a lot of people who want to make the USA a nation of Leftists, ruled by feelings instead of laws. Where the Constitution and courts are only something that conservatives must follow. Because the Left answers to a "higher cause". One of the items from Freakpages that I cite above, is Luxury Beliefs, like Defund the Police, or Cultural Appropriation. All these things came from elite New England private colleges where the students are from wealthy families who can afford to dabble with silly ideas. Who cares if some people think they're bullshit, right dahling?
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$236 Million Gavin Newsom Program to Help the Mentally Ill Has Helped Only 22 People in Four Years. It's kinda like Millions of Dollars in, OHSU Behavioral Health Coordination Center Has Aided Few Actual Patients. Mental health spending is just a boondoggle.
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Mary Bridge Children’s Hospital to close gender clinic. Finally. What a sick, medieval, barbaric practice that was. This will do down in the halls of medical horror and shame, that doctors practiced this.
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We've all been there. Rumination is the dark companion of anxiety and depression. Preventing you from doing things in your life to be productive or just helping you get out of your funk. Here's how to take steps to get yourself out of its grip.
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Interesting Tesla is going to phase out their highest priced Model X and Model S. Tesla will only make the cheapest Model 3 and Model Y. Instead, the company is transitioning to making humanoid robots.
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