Teclistamab extends remission in relapsed myeloma, with 70% progression-free at 18 months. Now this is truly remarkable, as anyone who has taken care of refractory myeloma can tell you. To stable disease at 18 months in refractory disease is incredible. Overall survival was improved as well. You still have to deal with cytokine release syndrome, but that's not unusual in myeloma, especially in people who have experienced daratumumab. But adverse events of grade 3 or 4 occurred in 84.9% of teclistamab recipients, so definitely, there is risk, as grade 4 toxicity usually lands you in the hospital at least for a while. Paper here.
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Perfect randomness realized for the first time. The standard for perfect randomness has changed over time. Now we have cryptocurrency and quantum computing, so what is considered random has to be perfect. No hidden probability distribution that can be reverse-engineered.
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I saw this article (Calling Doctor GPT: AI responses to healthcare queries are nearly 76% accurate). I saw that they were using really old LLMs, and brushed it off. We know that medical chatbots are not trustworthy to be accurate, but then this article came out which used modern LLMs (Beyond Benchmarks: Disagreement Among Frontier LLMs on Real-World Fact-Checks). Clearly, the reliability of chatbots is still less than ideal.
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New report shows annual app subscribers rarely return after they cancel. Psychologically, I'm more likely to continue using a good app if I pay once and can use it with free updates for a year or so, and then have the option to pay for a license upgrade if I want. This stikes the right balance between overly greedy developers and those who just want to be supported for their hard work.
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Blue Origin's Earth-Shattering Kaboom. By now, most people have seen the video of the Blue Origin explosion. That was huge. So huge that it may put Blue Origin out of commission for a while. Like well into 2027.
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Small colleges are hurting. One estimates that "442 of the approximately 1,700 private, nonprofit, degree-granting colleges and universities in the United States could face financial exigency within the next decade." Western Oregon, Southern Oregon and Eastern Oregon Universities as well as Portland State University are experiencing financial trouble. Enrollments are down and expenses are increasing. I'm sure many prospective students are wondering whether it's really worth it to go into debt for little return.
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I hope that mail-in voting will eventually disappear. No more cheating and post-election surprises!
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Vaccination Rates For Oregon Students Hit New Low in 2026. Trust in the medical profession is very low.
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Is Tesla's Model S Plaid a faster and more powerful car than the Ferrari Luce? That would be an embarrassement.
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Mystery company accidentally blew $500 million on Claude AI in a single month — failed to put usage limit on licenses for employees. I've read that it was Amazon. Oops.
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“Can I just say f**k AI, f**k AI, f**k AI?” the comedian, actor, and rotating host of The Daily Show asked in his keynote speech during the Class Day celebration on Wednesday. The crowd at Tercentenary Theatre, made up of the graduating Class of 2026 and their friends and families, answered him with a roar of approval.
“Raccoons live in alleys, storm drains, garbage nights, and morally humid environments,” it wrote. “Frogs have existential agency, while raccoons have logistical agency. A frog at a VC afterparty seems like an omen. A raccoon at a VC afterparty seems like it got on the guest list … Think: alley behind a conference hotel, the loading dock of a casino, the VC afterparty where everyone is saying ‘alignment’ but meaning ‘exit liquidity’ … Alignment sounds like ethics, safety, shared goals, humanity, the future. It has dry-cleaned blazer energy … Exit liquidity is socially clammy.”
Claude would not write this. This smells like ChatGPT.
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Gen Z men want kids. Gen Z women have questions. Modern society is so messed up. Humans can't accomplish simple biology now.
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Kyoto University Hospital launched the first human trial of an experimental drug named TRG-035. The initial safety study enrolled 30 adult males who were each missing at least one tooth. Developed by biotech startup Toregem BioPharma, the drug blocks a specific protein that acts as the body’s molecular off-switch for tooth development.
Scientists accidentally discover sea cucumber with 'tissue immortality'. Why is it that all of nature's creatures with regenerative superpowers like this have to be ugly? Like Deadpool.
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Anthropic reaches valuation of $965bn, beating OpenAI to become world’s most valuable AI firm. So different from a couple of years ago. Now, it seems that all OpenAI does it get embroiled in lawsuits. GPT models don't generate any excitement anymore. We look forward to the next Claude model. Or some Chinese model.
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Functional recovery of the adult murine hippocampus after cryopreservation by vitrification. Well, if we can't solve the challenge of storing our memories in some LLM, then maybe we can freeze our brains instead?
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