Lung cancers can use two different mechanisms to evade KRAS-inhibiting drugs. RAS inhibitors in lung cancer work differently from the multi-RAS inhibitor used in pancreatic cancer. Resistance has been an issue with targeted therapies for a long time, which has been challenge. The long-term good luck that was seen with imatinib against chronic myelogenous leukemia has not panned out in most other diseases. But understanding how breakthrough occurs is the first step in understanding how to improve these drugs.
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Five Things I Learned in Hiring a Financial Adviser. There's more to what a financial planner does than just pick stocks for you, or manage your portfolio. It helps to have someone evaluate your estate planning and tax situation as well.
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This morning there's been several articles about college graduates and their prospects afterwards. Here's one that questions whether you need to go to college in the first place. Fox News says that more Gen Z college freshmen are quitting school early and moving back home with mom and dad. Here's one that suggests that the quality of a college education has been declining. And a Gallup poll indicates that a record-low (31%) say that a college education Is 'Very Important'.
Here's a report that indicates that an increasing number of households are spending on AI, but only about 2% of households are paying for it. This suggests that there's still plenty of upside. Then they have to decide whether they'll put up with datacenters after all.
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Tesla's robotaxis won't operate at night because they have no Lidar. Waymo uses Lidar and operates 24 hours/day. But Musk doesn't believe in Lidar for some reason. Even Rivian uses Lidar.
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Mote is a website that lets you have private chats where nothing is recorded (by them) and it's all private. Don't we already have encrypted chat? Can we trust these folks? I can't find any information about who set this up.
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Property managers in Portland are finding that it's not safe to do their work now. And if tenants declare apartments to be off-limits, this is how you start to get no-go zones in your city. This is what Portland is becoming.
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