5 November 2025

Microsoft CEO says that they don't have enough power to use all their AI GPU chip hardware. Energy is clearly going to be the bottleneck factor. 

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Is metformin a cognitive enhancer? That's the tease of this article, although all that was demonstrated was that it improved his reaction time. 

Did I notice any practical improvements in cognition? The short answer is “no”: I didn’t notice any obvious differences in concentration, memory, or performance under cognitive load.

Yeah, clickbait title.

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In California, they are making their math geniuses get fingerprinted and entered into a criminal database. Students, teachers, as well as anyone who interacts with them. Also UC system students must affirm transgender ideology under the SHAPE program in order to stay enrolled. Because they have so many perverts and groomers?  How about letting students just be students? And being more selective about who you admit to these programs?

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The molecular underpinnings of Crohn's disease advanced by machine learning. They didn't use generative AI, but just good old-fashioned machine learning tools. They found that the NOD2 protein fails to suppress the inflammatory girdin protein, due to missing or dysfunctional binding site. Paper here.

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Some Substack writers are switching to Patreon. Some are switching to Ghost or Beehiiv. Competition is good.

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Nearly half of Oregon's healthcare workers are not vaccinated against the flu. It may just be too early to expect everyone to be vaccinated. Best to get vaccinated for influenza in late November, around Thanksgiving, because the flu season can last until April, and you want to make sure you have immunity that lasts that long.
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Where are the homeless from? It's hard to get accurate data, but the figure seems to be that around 20% came to Portland from elsewhere.

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Oregon has dropped further to 35th place is state tax competitiveness. Competitiveness and Oregon seem to be two words you'd not find in the same sentence. Hard to believe that we were #7 in 2019.  Reminder Kate Brown was in office from 2015 - 2023. COVID-19 hit and because of Dem policies, the state has never recovered. It seems that Oregon has slipped past an invisible event horizon, and there is no other path that toward the center of the black hole.

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