Sugoi & Yokunai

I missed this last month, but the phase III DeLLphi-305 trial showed that adding tarlatamab to durvalumab maintenance in extensive stage small cell lung cancer markedly improved progression-overall survival. So this is the new standard of care, and will probably make Amgen some money. IMDELLTRA is a bispecific T-cell engager, binding to both DLL3 (a Notch pathway ligand) and CD3, the T-cell receptor.

As you can see,the survival curve is a "banana curve", and the two graphs eventually intersect, but perhaps with further follow-up, they will stay separated.

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AI can turn your Instagram posts into scam that know a little too much about you. Scammers will always use tech for fraudulent purposes. If you get spam email that seems to know personal details, this may be why. Everything that you do that can seem innocent or good-intentioned can turn into something sinister.

And be careful when you order takeout online. Misspellings can be costly. And they are getting more clever in their scams, too. 

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Vibrating mattress helps clear Alzheimer’s protein from the brain. Some of the motels run by Motel 6 used to offer vibrating beds for massage. Gosh, I could have taken some nitroglycerin tables and done myself a favor. This study seems hokey. Mattress vibations for 37 minutes? Really? How did this get into Nature Communications?

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The Washington Post published an article stating that the effect of modern dataceters in raising the price of electricity is largely overstated. But the commenters just doubt the article. They won't listen to facts. They assume bias. 

Here's an Oregon startup, Panthalassa, that plans to build datacenters in the ocean instead. So all the complaints about water and taking away electricity will be moot. Sounds more realistic than building datacenters in space or on the moon, as I've heard. I hope these guys figure out a way to make it happen.

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The AI Rebound: Why Companies Are Rehiring Workers They Replaced. I knew this would happen. AI isn't that good - yet.

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Why Americans Stopped Throwing Dinner Parties. Heh, it's not just me!

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Shrubbery vanishes from heavily-used Woodstock crossing. Someone took matters into their own hands! Love it!

Portland let some bushes grow to where it was causing a danger. 

Gene Dieringer, a longtime member of the Stakeholders Group and of the WCBA, further elaborated: “We advised the city over a year ago that that the Stakeholders would no longer be maintaining the median islands, largely because the city said we would be liable if we did.”

Why legally liable? The Portland Bureau of Transportation (PBOT) says if citizens step in to fix or maintain public “Main Streets” (and Woodstock Blvd. is a Main Street) or local right-of-way infrastructures, they face bureaucratic, legal, and financial hurdles. Any damage to the island caused by accidents or vandalism would therefore be the Stakeholders’ liability, if they continued maintenance. Thus, since 2025, the shrubs and foliage have grown without pruning.

Portland is the "City that Forgot How to Work".

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