Experts may have found a surprising driver of low testosterone. Nah, this is not a new thing. We've known that belly and visceral fat is associated with low-T. Adipose tissue has aromatase activity, which converts testosterone into estrogens. So getting rid of excess fat is essential.
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The reason why large dogs don't survive for very long is believed to be faster aging due to inability to suppress the effects of jumping genes:
Differences in dog aging may arise partly from specific jumping genes known as LINE1s, the authors report. LINE1s can damage DNA as they roam the genome, a threat normally mitigated by DNA methylation.More than 40 percent of LINE1-associated genome regions lost methylation as dogs aged, the study found, with different dogs declining at different rates.The loss unfolded significantly faster in larger breeds, which lost about 35 percent more LINE1 methylation annually than smaller breeds did.
So it's slow genetic decline. But why are LINE1 effects so predominant in dogs?
Trump administration's embrace of "perp" futures sets off risk alarms for Wall Street stalwarts. I don't trade in future contracts, but like everything else, change happens. Traders don't like it because they like to work 9 to 4, Monday to Friday, whereas "perps" are always trading. "Unfair competition" they say. What this will do to the dominance of Wall Street and the CBOE is unclear. And ties to cryptocurrency make the whole sound quite risky.
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A friend sent me this:
It turns out, the U.S. is ranked #21. But we lead the world in obstructing datacenter projects! Getting dumber and dumber. And when it comes to states, Washington and Oregon residents are not heavy AI users either.
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Editorial: A mandate for more of the same? Please, no. This is hilarious. After endorsing Kotek, the Oregonian editorial staff suddenly discovers it has a distaste for Dem policies. Not only that but in Multnomah County as well. Well, too bad, Dem voter. Don't say you weren't warned.
The change needs to start at the top with Kotek.
For her second term, Kotek needs to adopt and execute on a vision for reviving the state by addressing the structural
issues weakening public services, rather than attempting to solve them by fiat.
She should start by focusing on Oregon’s economy — the most critical component for the state to be able to solve any of its other crises.
What a joke. Why should Kotek change now? How about letting a Republican have a chance, for a change?
And here's another headline: Oregon Ranking Drops Further in Tax Competitiveness Index.
14 Portland public schools may close. And Portland Public Schools is protesting. Without achievement targets, PPS seems to exist just to give teachers a job and a pension. Educating kids seems not their primary goal – since with no testing metrics, teachers have no idea how well they perform their jobs. And days off are granted for protesting. And everyone graduates – if they bother to attend school at all.
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A Seattle Redditor expresses Homeless fatigue after being punched in the face. A city in decline.