15 October 2025

Well, this video might convince me to get the iPhone 17 after all.  There's no music released yet to take advantage of this yet, however, so no rush. Why haven't I heard of SPR-AVS and ASAF outside of this video?

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A detailed look at how modern browsers work, in case you were ever interested.

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The Japanese government wants people to stop using manga and anime art to train AI.  Yeah, good luck with that. Toothpaste is already out of the tube.

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Looks like transgenderism is on the decline amongst American students. Thank goodness. Probably because the weirdos took over the image and made it look just mentally ill instead of something cool. Paper here.

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New Alzheimer's Treatment Clears Plaques From Brains of Mice Within Hours.  This is remarkable. They used nanoparticle delivered drugs and ultrasound to relax the blood-brain barrier. Worked like a charm. Now to see if humans can be helped.

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Top US Army General Says He’s Letting ChatGPT Make Military Decisions. Uh no. I don't think this is proper. We shouldn't be waging war like this.

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Humans on bikes are very energy-efficient it turns out.

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Here's an argument for why AI is not in a bubble.  Dang, you need a subscription to learn why. And I dunno, just a couple of weeks earlier, Derek wrote about how the AI bubble will pop. This all sounds like clickbait, doesn't it? 

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Get a load of this. The Reynolds district is running out of money. So they have to shorten the school year because the teachers got an expensive raise. But this will put their school year below Oregon's school year length requirement. So what will they do? Why apply for a waiver with the state, of course. Because f*ck the kids, that's why.

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Portland Dems and Antifa supporters like to say that Portland is entirely normal, and there's no need for any law enforcement. Take a look at Kevin Dahlgren's snapshot of downtown Portland. The Dems want you to be conditioned to think this is perfectly normal. 
This is the frog in the boiling pot. If you see this enough, you get numbed. Happens all the time. Nothing to worry about. Keep electing Dems.

And Seattle's response to all the prostitutes on Aurora Avenue is to issue a stern letter. Yeah, that'll take care of the problem. 

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And this is why they need all that tax money – to pay for illegal aliens healthcare.  This underlies the Schumer Shutdown. 

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14 October 2025

Alzheimer's disease may not be a brain disorder after all? This theory says that beta-amyloid is a normal component of the brain, and is part of the immune response.

In our model of Alzheimer's, beta-amyloid helps to protect and bolster our immune system, but unfortunately, it also plays a central role in the autoimmune process that, we believe, may lead to the development of Alzheimer's.

When brain trauma occurs or when bacteria are present in the brain, beta-amyloid is a key contributor to the brain's comprehensive immune response. And this is where the problem begins.

Because of striking similarities between the fat molecules that make up both the membranes of bacteria and the membranes of brain cells, beta-amyloid cannot tell the difference between invading bacteria and host brain cells, and mistakenly attacks the very brain cells it is supposed to be protecting.

So attacking beta-amyloid with monoclonal antibodies may be the wrong approach.

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Influencers are out of a job. Now companies can create AI influencers and post them to TikTok. And they won't ask for free stuff or cause problems like real influencers.

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Wow, ProtonVPN does log user data after all.  They say they respect privacy and don't keep logs, but "ProtonVPN can inspect your traffic and tie it back to your account." Not good. NordVPN gets my money now.

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Comparison between Tim Cook and Steve Jobs.  Tim Cook definitely kept the plates spinning, but innovation-wise, it hasn't been the same.

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New California law requires AI to tell you it’s AI.  Leave it to California to pass the dumbest laws. The lawmakers there are just schoolchildren in adult bodies. 

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Here's a theory that purports to explain why you can be so confidently wrong about something. Why you might have poor judgment about reality. Information that seems to be easily absorbed and processed could be wrong. Kind of like TikTok News.

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What causes chemo brain? Researchers at Fralin Biomedical Research Institute and Virginia Tech's Department of Biomedical Engineering and Mechanics have found chemo-induced abnormalities in the glymphatic system.

The study examined effects of two of the most common chemotherapy drugs, docetaxel and carboplatin. While both showed lymphatic system impacts, they were much more pronounced with docetaxel.

"What we see is a shrinking of the lymphatic vessels, and fewer loops or branches in the vessels," said Munson, who is also a professor in Virginia Tech's Department of Biomedical Engineering and Mechanics. "These are signs of reduced growth that indicate the lymphatics are changing, or not regenerating in beneficial ways. Lymphatic health really declined across all three models measured in different ways."

Hope these alterations improve. Not everyone gets them. Perhaps this is why exercise seems to cause improvement because it does get the glymphatic system more active.  Paper here.

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What makes a startup company more likely to succeed? Perhaps if it is a "fuck you company". Think about it. We love to do something when we think we're sending a "fuck you" message to some large dominant corporation.  Here we are, sticking it to the man, right? Otherwise, nobody cares about your little startup that just solves a problem nobody has, or is just a little better but requires some effort to change your routine. Nobody cares about a better YouTube or a better Facebook. But what if you could say Fuck You to the tax industry? Hotel industry? Brokerage industry? Don't just be better. Be different.

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The Nobel Prize in Literature Is Boring Now. Yeah, who really cares? I generally don't read that boring stuff.

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In Seattle, all those new taxes are causing small businesses to close. And they think it makes Portland more competitive now. Funny.

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There's a YT video about the vast network of license plate readers across the country.  Yeah, it's an invasion of privacy, but it's the consequence of having so many criminal elements running around. But the thing that seems to get the person who made the video is that it's helping ICE catch illegal aliens. Really?  That's what you're upset about?  

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This is why you have to read conservative media. You miss out on a lot of things.  Some major news.

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West Linn is the safest city in Oregon.  Coos Bay is the most dangerous. In Washington, Sammamish was the safest and Tukwila was the most dangerous, no surprises here. 
In the nation, the safest states are Red states, and the most crime ridden are Blue states. This is why much of Oregon wants to become part of Idaho. 

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TriMet plans service reductions starting next month, 'deeper cuts' in 2026.  Just as well. Public transportation in Portland is just crime on wheels. Thanks to TriMet, "Portland's Best" can spread their urban goodness to neighboring cities. 

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13 October 2025

Poor Tommy Flowers never got the recognition he deserved designing the first electronic computer.

The world’s first digital electronic computer, forerunner of the ones reshaping our world today, was built in Britain to revolutionise codebreaking during the second world war – a mind-boggling feat of creative innovation – but Turing wasn’t in the country at the time. Neither was it conceived by the mostly private school and Oxbridge-educated boffins at Bletchley Park. Rather, the machine Park staff called Colossus was the brainchild of a degreeless Post Office engineer named Tommy Flowers, a cockney bricklayer’s son who for decades was prevented by the Official Secrets Act from acknowledging his achievement.

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The Myth of Falling Crime: Why Americans Don’t Trust the Numbers.  Yup, the official crime statistics are fake and no one believes them.  And here's Ranked: Europe’s Most Dangerous Cities, According to Citizens.

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It may be time for the U.S. to copy China this time. China builds new self-healing battery for EVs and phones with triple lifespan.
And China is going big on robots, have you heard? They're not the robot arms that we're used to seeing here, but humanoid robots. 

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Bride surprises new husband with an RTX 5090 on wedding day.  Forget love and romance. It's time to install this baby and run some inference on machine learning models. Maybe mine some coin. Amirite?

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Forget M4. Apple will be ready to release M5 Macbook Pros.  The commenters are unimpressed. Yeah, it's been tough to notice significant improvements with each release. More incremental than impressive. Apple does seem to have run out of new ideas. I'll still give this a sugoi though. 

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You can hide malware in DNS records now. How widespread is this?

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In computer science, in the section on networks, you've probably heard about Dijkstra's Algorithm, computing the shortest distance between two points. Well, some scientists found a faster way of calculating this. This is important for things like stereotactic radiosurgery, where a thin beam of radiation blasts a tumor in different directions, and the intersection of all these beams is where the radiation intensity is the highest. Picture a head with dots on it, marking where the beam will be directed – that's the network. You want to calculate the quickest path that will direct the beam from all different directions, and this calculation will do that.

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Canadians were shunning Oregon this summer.  Certainly understandable. The state has gotten less attractive. And I'm not even talking about the recent naked bike ride. Ewww.

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As they say in medicine: Great case! A great clinician deduces the cause of a medical mystery, without using AI. Actually it would be interesting to see if AI could deduce the cause of this man's symptoms.

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Disgusting. Oregon Now Spends More On Program Offering Free Health Care For Illegal Immigrants Than State Police. It's for this that the government is currently shut down. Enough already. 

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12 October 2025

Botrank.io is the first and so far only ranking site for consumer robots.

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K102 and K110 are compounds that purportedly help regenerate the damaged myelin sheath in patients with multiple sclerosis. They are two chloroindazole-based estrogen receptor-β-selective ligands. Paper here.

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Someone else doesn't want to use Microsoft's OneDrive for hard disk backup. Why is Microsoft doing this all of a sudden? It's like Apple forcing people to use iCloud, which I also dislike.

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I've wondered about this. It was accepted as perfectly fine and normal for women athletes to being amenorrheic. But it was actually making them develop osteoporosis, and who knows what else, since it's believed to be caused by  increased energy expenditure and/or insufficient nutrient intake combined with physical and psychological stress, and low leptic levels. The end result is suppression of hypothalamic-hypophyseal function, which can affect a wide range of hormones.  It's energy deficiency from increased energy expenditure and/or insufficient nutrient intake, making the body think it's starving. It's not a healthy response, and now women are paying the price.

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Oregon ‘underemployment’ is rising rapidly.  The U-6 is going the wrong way. What's going to happen when people don't qualify for SNAP anymore and have to look for a job, but there are no jobs around because Oregon's economy sucks? Maybe people will move away. Maybe there will be more home break-ins. And since the police don't arrest crooks much anymore, and prosecutors seem to release criminals without charges, things will only get worse.

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The job where people get the most injuries are jobs at nursing and residential care facilities. Working at hospitals is #4. The society we live in now.

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11 October 2025

Probably the same thing as with any other language. What Happens In The Brain When People Grow Up Speaking Hawaiian And English?  I thought I was going to get an answer.

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Discord hack shows risks of online age checks. This is what happens when you force people to collect sensitive information, but let them figure out to do it securely. Yeah, they got hacked, and now all that information is probably on the darknet.

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When did the term liberalism go from meaning limiting the power of government, individualism, protecting personal property and freedom of speech, to its modern meaning of just being anti-conservative (tax the rich, free stuff for the poor, censor and attack opposing viewpoints)? Now, being called a liberal is more like an insult.

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Another theory behind LongCOVID from researchers at the Graduate School of Medicine at Yokohama City University.
By comparing imaging data from 30 patients with Long COVID to 80 healthy individuals, the researchers found a notable and widespread increase in the density of AMPA receptors across the brains of patients. This elevated receptor density was directly correlated with the severity of their cognitive impairment, suggesting a clear link between these molecular changes and the symptoms. Additionally, the concentrations of various inflammatory markers were also correlated with AMPAR levels, indicating a possible interaction between inflammation and receptor expression. 
Since I've been doing this blog, there have been so many "theories" as to what the key culprit is;
  • genetic variants associated with the FOXP4 gene (12 July 2023)
  • persistence of SARS-CoV2 spike protein (5 September 2023)
  • amyloid deposition in the muscles of those with LongCOVID (7 January 2024)
  • a leaky blood-brain barrier (24 February 2024)
  • detectable ghost proteins (fragment of viral spike protein) in their blood. (25 August 2025)
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Reddit can be evil. Lars Lofgren describes how one Reddit moderator with an evil fixation was able to destroy a competitor's business.

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What? So the U-shaped curve showing how happiness increases again in the elderly was bogus? You mean it was just a trope? So this old ronin is not likely to be really happy once he recovers from mid-life crisis?  Dang, I was looking forward to it.  The curve actually looks like this:

Happiness declines slowly over adulthood (about half a scale point). A low point is reached in the late 50s—at ages 55, 58, and 59. Subsequently, happiness increases slightly during the golden ages (about a tenth of a scale point), peaking at age 64. In old age, a steep decline in subjective well-being sets in. 
This actually makes sense. Why would you feel happier in your later years when infirmity sets in? Paper here.

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Democrat mayoral frontrunner for Seattle, Katie Wilson, has a really crazy idea. She wants taxpaper money to go to pay for all those shady "news outlets" that no one reads. Rags like The Urbanist, Publicola, and the South Seattle Emerald.

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Microsoft Word will now, by default, save your documents to their OneDrive. And if you save photos to OneDrive, Microsoft will automatically use face recognition on them, like with Facebook. You have only 3 specific times a year to opt-out, and they don't tell you when those dates are. What is it with their sudden desire to get people to use OneDrive?

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Portland to open 3 new overnight-only shelters in undisclosed locations. They don't want to tell you where these locations are, so you can protest and raise objections. Until it's too late. Where's it going to be? Here? There? Maybe Willamette Week will find out, because it certainly isn't going to be The Oregonian. 
Keith Wilson is determined to turn Portland into a wasteland.

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10 October 2025

Google ex-CEO Eric Schmidt warns against homicidal AI robots. But yet, people will press on, because the Moloch effect is too strong.

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Trump knows he won't get the Nobel Peace Prize today. But whoever gets it is going to look awfully lame compared to Trump, and it will be so obvious that it was a political snub. Like Melania Trump not being on the cover of Vogue, but Michelle Obama was. C'mon. Einstein didn't get the Nobel Prize for his theories of relativity because the Nobel committee was anti-semitic. They finally had to give it to him for something, and so they picked the photoelectric effect, which is a lame excuse. Same thing here. So who will get it this year? Greta Thunberg? Are they going to give a joint award to al-Haddad and Netanyahu and leave Trump and Kushner out of it? Whatever it is, it will likely be a big joke, and no wonder the Norwegian government is preparing for a backlash.

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Another attempt to use AI to replace doctors falls flat. Forward AI bites the dust.

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Someone really likes the new Logitech MX Master 4. I've ordered one – it's on its way.

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Which cars get pooped on the most by birds? Turns out that it's not random. Ram truck and Jeeps are their favorites. They love to drop on brown, black and red cars. Silver cars have the least poop.

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Now there's a device that provides electrical assistance to walking.  I suppose it has its uses, especially in helping the elderly or disabled to walk again.

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I can't believe Lyft was actually considering letting potential drivers know people's tipping history. As the GenZers say "F#ck that".

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It's trivially easy to poison LLMs into spitting out gibberish, says Anthropic. Yeah, it really does seem that the more we know about LLMs, the less impressive they seem.

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I was thinking it might be good to invest in datacenters. Maybe not.  But OpenAI keeps making new deals, and I'm sure they're going to involve datacenters.

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The Nobel Peace Prize was awarded to some no-name Venezuelan activist. That kind of achievement might merit a Google Doodle, but not the Nobel Prize. They sure went out of their way to snub Trump, didn't they?

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9 October 2025

Scientist claim to have developed a test for ME/CFS.  

they said the test had a sensitivity – or the likelihood of a test being positive if that patient has the condition – of 92%. It had a specificity – the probability the test will rule out negative cases – of 98%.

Impressive. Let's see how well it holds up against new cases.

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Yup. Legalizing weed was a bad idea. But it's probably impossible to put the toothpaste back into the tube.

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Frog.cc looks interesting. I haven't tried it out. Looks more gimmicky than something actually useful. In my experience, developing a really useful and interesting app takes a lot of massaging and editing. This is just an interface that has a lot of the helpful prompts already in place.

I understand this. AI gets more 'meh' as you get to know it better, researchers discover. Just a few years ago, we thought ChatGPT was magical. Now, it's "meh". We are so quickly jaded. But yeah, we can see the flaws and limitations now. I think AI is too overextended and doesn't live up to some of the hype. 
 
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This is cool.  Scientists Just Reversed Alzheimer’s in Mice. They developed nanoparticles that acted on the blood-brain barrier, activating a feedback mechanism that enhanced a clearance pathway that reduced amyloid accumulation. Paper here.

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Cocoa extract can reduce markers of chronic inflammation. This study didn't show any other endpoints, however. Still, it supports other studies in favor of cocoa flavonols. This made me look up CocoaVia and I see they're still in business. I tried them once for a few months, and didn't notice any difference and stopped. Supposedly measurable benefits can be seen in a few weeks. Maybe I was just too young to notice a difference back then.

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Portland grocery stores are locking up Top Ramen because of the "bottom quintile" people. We live in a city where we can't have nice things. 

And speaking of Portland, WWeek published some of the Peacock messages that the city council chatted on recently. The city council members think that the crash in housing and property prices in the city is a good thing, because they thought the prices were too high to begin with. And also, it presents a "buying opportunity" for the city. Yeah, forget that it makes a lot of peoples' mortgages underwater, not to mention investors, and it discourages investment. They still need to collect rent to make it all pencil out. Since when is debasing people's assets a good thing. Plus, the city has no business trying to buy property. Just manage the city for pete's sake. This attitude is basically why they think nothing of trashing the city with homeless shelters and deflection centers and detox centers, not to mention graffiti and trash.

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There's an AI Agent craze right now. Everybody has a course to teach it. Let an AI Agent take control of your computer and do things autonomously. What could go wrong? Well at last, someone is sounding the alarm.  Not so fast. Security measures aren't always in place, and these things could do a lot of harm, and cause a great deal of embarrassement. This is why I refuse to use AI browsers just yet.

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Wow, OHSU's Lawrence Furnstahl will depart in a month and a half. They're going to have to find someone else willing to take on OHSU's financial problems. Either they promote from within, or try to convince some poor slob to move to Portland. Good luck with that.
Portland Opera is facing the same difficulty. Their general manager is retiring. I haven't been to Portland Opera at all – no compelling reason. I want to see the extravagant, classical shows like I saw in San Francisco. Not modern, urban re-interpretations for hipster audiences. Call me old-fashioned.

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Even the Washington Post admits that Obamacare was never affordable. It's a socialist money-sink that depends on subsidies to operate. Trump is correct in letting it slide, but needs to put something in place that people can latch onto. This is something that was missing even with his 2017 effort.

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Timberline Lodge ticket prices will soar as insurance costs increase 586%. Holy crap!  What will the Dems blame this on? Trump's tariffs? Climate change? Palestine? Russian interference?

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When you see PISA test scores, you generally only see country-level rankings, but never a breakdown. It turns out that America's Asians outperform other Asians, and America's Whites outperform other Whites.

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Horrible, if true.

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8 October 2025

$2 Trillion in Potential Shutdown Savings if Trump, Vought Step Up. Wow, if the Dems don't acquiesce soon, the country could save a lot of money trimming the fat.

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The Biggest Names in Tech Can't Build the AI Device You Won't Want to Buy. Heh, I didn't have to click the article to know what it was about. I agree – Jony Ive's new device is likely to join the ranks of Google Glass, Rabbit R1, Friend, and the Segway. Prove me wrong, Jony! 

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First CAR-T cells, now CAR-NK cells. I've always considered the NK cells to be the real bad boys. The trouble is, they were selective in who they targeted, and it was tough to motivate them to kill things that needed killing. But perhaps not anymore.

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Scientists discover neurons that are activated when it's time to make decisions. When the situation is uncertain, these neurons turn on, and are believed to help with the decision-making process somehow. It looks like these neurons help keep track of what decision was a good one or not, by providing the appropriate reward signal. Perhaps there is a condition associated with not having enough of these cells.

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Another reminder – ChatGPT is not private. They confirmed that the Pacific Palisades arson was the right guy not only by checking is online searches but also ChatGPT.

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It looks like the eastern part of many cities is the poor side.  Seattle is an anomaly – the eastern part has Laurelhurst and Madison Park, and if you go further east you get Bellevue and Redmond. If you go west, you get West Seattle, Queen Anne and Ballard. Only near the water do you see some affluence again in Magnolia, but even so, it's just a wee bit better. You still get the homeless around Golden Gardens and Carkeek Park and Blue Ridge ain't that nice either.  So why is this? The article presents a theory.

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CSS has 42 units now. Wow, who knew?  I learned something today.

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Holy crap! Looks like it's going to get a lot more expensive to use ambulance services in Washington County. 30% higher!

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7 October 2025

AMD stock skyrockets 23% as OpenAI takes 10% stake. Man, OpenAI is making everybody rich, it seems. Hope this lasts.

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Avoiding Google is really difficult. You may choose not to use Google products, but when you interact with someone who uses Google, then Google finds out anyway.

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Yeah, I remember when reading immunology papers, suddenly I started seeing mentions of T-reg cells. T-regs weren't mentioned in the immunology textbook I read in the 1990s. Because that was before 2001 and the Foxp3 paper. Even so, it took a few years before the new name started to catch on. That's what this year's Nobel Prize in Medicine is all about – how T-reg cells came to be recognized.

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Invasion of privacy. Amazon's Ring system will start to use face recognition.

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OpenAI Sneezes, and Software Firms Catch a Cold. Geez, if OpenAI even looks like it might develop an app that does something similar to what you do, your stock may tank. People need to dial it back.

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Gifted children are special needs children. It's interesting that Blue state leaders are so quick to dismiss programs for the gifted, like Washington, California and now New York. And that it's Asians that suffer for it. And yet most Asians support Democrats. A political party can bomb Japan and put Japanese in internment camps, and still they vote Democrat. Make it make sense.

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GPT-5 Pro is out, and boy is it expensive!  I see that it's been added to Poe, and I'm eager to try it out on some tough problem, like a coding problem that lesser models get stuck on.

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There's going to be a Texas Stock Exchange. Y'all Street. Love it.

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Here's a guy who had the genetic mutation to get Alzheimer's disease, but he hasn't gotten it – so far. The mystery is – why not? Was it something he did? Or is the genetics wrong?

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The intrepid Kevin Dahlgren illustrates why providing housing isn't going to solve the homeless problem.

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Shocking if true. No one else is talking about this. The Pension Benefit Guaranty Corporation might be eliminated due to the government shutdown. This is the entity that rescues failing pension programs. Like PERS. If it is eliminated, or turned over to the states, then a lot of union pensions will be in jeopardy. All those nice pensions that they negotiated for themselves could disappear. The taxpayer would no longer be on the hook for their fat retirement pensions. If money runs out, it runs out. 

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6 October 2025

Tonight is a supermoon night.  And the skies should be clear.  😁

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This article reveals that as with Google search, what you type into ChatGPT can come back to bite you. It's not private at all.

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The Nobel Prize in Medicine was announced today, and what I notice is that two of the winners were not in academics, but in industry. Well, the Institute for Systems Biology is a non-profit research organization, co-founded by Leroy Hood who left University of Washington, along with Roger Perlmutter. Only Sakaguchi was an academic.

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Could Mark Gurman be Apple's next CEO?

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WiFi signals can detect heartbeats. This is amazing, and may aid in rescue operations, if you can detect a heartbeat even though the person isn't in direct visual range. Or the military can use it to detect hidden dangers.

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GPT-5 Pro solved two dificult math problems: Yu Tsumura’s 554th Problem and Disproving Majority Optimality.  I would love to play with GPT-5 Pro.

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This Seattle Times reporter thinks people should offer the homeless shelter where they live.  Well the owner of the Civic Hotel wanted to help out the city of Seattle but letting the homeless stay in the hotel. Well, guess what happened?  Now the hotel is ruined with meth and fentanyl residue, and the city is dragging their feet in addressing the situation. More on the story here. The hotel was pretty nice, and now it's trashed. Too bad. 

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