This is going to be a real problem. AI is getting so good that keeping patients de-identified to meet HIPAA compliance is getting to be impossible. Once patients are aware of this, clinical trial participation could decrease, and research could be negatively impacted. Someone with ML cred needs to examine the HIPAA Safe Harbor standards and explore how to keep PHI really protected, in deed not just in name. I have an idea that I thought of during an informatics course I took. It would put control of personal information in the hands of the patient, not the hospital or insurance company. Would love to discuss with anyone in the field.
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Health care is the 'engine' of the job market — and that's risky for the economy. What does it mean when the largest employer or largest company in the state is a hospital system? It doesn't mean that people are getting healthier. For Oregon, the hospital industry is indeed dominant, and in cities like Eugene, much of the hiring is for hospitals and clinics. This means that unions are fed, and ultimately healthcare gets expensive and unaffordable to a lot of people. Growth of the healthcare industry usually means growth in insurance costs, and as mentioned, costs to satisfy unionized employees. It's a bubble that has to pop. We've got to get unions out of so many things, and the healthcare system is one of the most urgent.
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The "Are You Sure?" Problem. Great exercise for students when learning about LLMs. Ask the LLM if it is sure about an answer. You'd be surprised at how often the confident answer become unconfident.
And I agree with this guy: it's too soon to dismiss human-developed software in favor of DIY efforts.
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The Prediction Singularity Is Upon Us. It's fun to build financial predictors to guide stock market investments. Many folks are doing that already, and the tools are freely available. Going for the general predictive market is more challenging, but should be doable. Aside from Black Swans, we should soon get pretty good at being able to predict things. Maybe in another year or so.
Take a look at this tidbit regarding the Epstein files affair. I hadn't realized that women in the vocal crowd that are crying "victim" were adults at the time of their involvement with Epstein. They weren't underage and should have known what they were doing. Why has no "journalist" mentioned this?
And then there is SB1850, another disastrous bit of legislation where news aggregation sites need to pay Oregon media to link to stories generated by "news sources". So Google won't be able to even provide a link to an OregonLive story with a description without falling afoul of this. So if you want to search for Oregon stories on a search engine, you won't get anything from mainstream media sources unless they have a legal agreement in place, which will likely mean payment. What will happen to OregonLive's visit rate? Social media sites and smaller amateur blogs will likely replace the mainstream outlets, which will see their revenue drop. I'm betting this is going to fail.
And to the Washington Post journalists who lost their jobs, remember that you posted this once before:
Frequent Diet Soda Intake Linked to Fourfold Increased Dementia Risk. And of course, I want to find out what artificial sweeteners were studied, and it's behind a paywall. You'd think that the reporter would do the due diligence and find out, but journalists are so incurious these days.
No one wants to ration, but if you don’t have enough money, you’re going to ration it either by dropping people or by cutting benefits or by cutting what you pay providers. That’s really the only three options you’ve got. We all do it. We’re just trying to do it openly.
No we don't have to ration care. That's the Democrat approach, endorsed by Ezekiel Emanuel. No no no! There are better ways, and Trump is working on it. It involves taking away control from insurance companies (and empowering the consumer), and they won't like it at all.
The Beginning of the End for Big Corporate Medicine. Will this ever happen? If it is, it will have to be in this administration. No other one will have the guts to take it on. Medical care used to be between doctors and patients, but now it's between doctors and insurance companies, and insurance companies and patients. Obamacare was when it really got out of control. Insurance companies were rolling in the dough. That was when Moda paid for naming rights to the Rose Garden Arena (2013), and Providence put their name on Jeld-Wen Field (2014). You can't sum it better than Portland's own Dr. Glaucomfleck.
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High-Deductible health plans worsen mortality among cancer survivors. Most people aren't trained actuaries, and have a hard time estimating risk. What sounded reasonable at one point in your life can be a big mistake later. For cancer patients, especially, being able to access your doctor shouldn't be something you have to think twice or thrice about.
I’m now a whole full Professor of Computer Science at a top university, with all kinds of fancy metrics and titles to point to.
The question is: how the hell can I be a successful AI researcher without knowing math? The implication is that I’m lying, or at least grossly exaggerating, because we all know that machine learning is very mathematical.
I write for those who have been thinking of learning computer science, but are afraid to try because they don’t like math or are bad at it. You can certainly do it. You can become a very good computer scientist despite sucking at math. If anyone tells you that you can’t learn, say, machine learning because you don’t have the “mathematical fundamentals” tell them to go to Helsinki. In the winter.
This is true to some degree, but being good at math gives you that extra insight that can help you.
Then there's Mrinank Sharma at Anthropic, who announced that he's quitting because the "world is in peril". I kid you not, he used those terms. Then he said he said the time had come to "move on" and pursue work more aligned with his personal values and sense of integrity. Whuut? Is this guy worried about world peril? Or is he just burnt out? Maybe the latter and he's being a drama queen.
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Richard Feynman had an extensive FBI file. The question is: who smeared him? This guy has a theory, and it would certainly make sense. This is so true, guys:
Darnold’s bill to the Golden State will be $249,000. The outlet stated the sizable check is due to California’s “jock taxes,” which force pro athletes who don’t live in the state to fork over percentages of their yearly income based on the number of days they work in California.
Welcome to California, land of Democrats. You got money? Gimme, gimme!
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And here's Oregon. Lawmakers want to lower the cost of building affordable housing. Sounds good, right? But there's this prevailing wage law, which mandates that contractors pay union wage rates to workers on publicly subsidized projects. SB 1566 wants to change that, as union wages add 10% to 20% to project costs. So will they piss of labor unions, or give up trying to do the right thing?
Living in the inflection point: "It’s scary because I don’t know what the future of my own job looks
like. A skillset that was previously highly valued is now much easier to replicate with AI tools."
No one wants to admit the real reason corporations are laying off thousands: "If you are a corporate employee whose job is reliant on a computer, there is a high probability that you will someday be replaced by AI. This will happen. But there is something you can do to avoid this fate: Be valuable."
Rather than crank out code to meet the needs of some company, it's time to look around the world and see what problems need solving and use AI tools to start fixing them. Be valuable.
Bloomberg has this article: How to Tax a Trillionaire, and says that politicians need to find smarter ways to do it because extremely wealthy people will always find a way to escape. But it's clear that the author is pro-tax. He concludes with
After all, as Supreme Court Justice Oliver Wendell Holmes Jr. once put it: “Taxes are what we pay for civilized society.”
Yeah, well despite all the taxes we pay, we're not getting anywhere near a civilized society. I repost this meme:
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Speaking of finding a problem the world has and figuring out to solve it, I came across this article: ReMemory Is The Amnesia-hedging Buddy Backup You Didn’t Know You Needed. I clicked because I didn't know I needed it either. It's a system where you break up an important secret into several pieces and give each piece to several friends. Only by putting together each component can the secret be revealed. Clever, huh? The author even supplied the code for this. But as the commenters say:
Just hope you remember which tool you used for this, and which friends you picked to hold the secret.
And hope your not ghosted by your /friends/.
And that your friends themselves did not forget or lost the piece of information they should retain.
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Some hacker tips, which I will probably never use. I'm seeing IVPN come up again. Maybe I should give them another look.
The NYT statement about who was in the study is a little misleading. The study population consisted of men and women of ages as young as 30 but the objective analysis was just limited to those over 70 years old (Tables 12 and 13 in the supplement). The best way to see what population was analyzed is eFigure 1 of the the Supplement. So the objective analysis was indeed based on those who were 70 years old or more (but not sure if they were all female).
National Cancer Institute studying ivermectin’s ‘ability to kill cancer cells. I gotta agree with the critics on this one. I don't think it's the best use of funds to spend to see if ivermectin can be repurposed as an anticancer agent. Oncology therapeutics is going beyond the old repurposing or screen-everything days. In the age of GenAI and other advanced drug discovery tech, there is no need to revisit ivermectin, especially when there is no compelling preliminary data.
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I saw this article: Do women really select for intelligence?. And then I read this article in the WSJ: A Stanford Experiment to Pair 5,000 Singles Has Taken Over Campus. Apparently its attracting a lot of attention, as new things often do. But it's not clear that people are getting hook-ups as a result. The data show that good-looking men score. Nerds generally don't. What women really seek is success, especially financial success. That's more than just intelligence.
That paper that came out showing that time of day matters a lot on the survival outcome of chemotherapy has gotten intense scrutiny. There's some reasonable criticism. It doesn't seem to make sense that just by giving chemotherapy in the afternoon, you lose all the survival benefit of treatment when the antibody itself lasts a long time. Some question the flow cytometry and I don't have expertise to critique that. But the reviewer seems to think that the latest paper is actually on the same population as the earlier 2025 paper, which doesn't make sense because the 2025 paper went out to 44 months, whereas the recent paper only went out to 34 months.
Blood omega-3 is inversely related to risk of early-onset dementia. Although not explicitly stated, it seems that the most important components in this are the non-DHA components, namely Alpha-linolenic acid [ALA], Eicosapentaenoic acid [EPA], and Docosapentaenoic acid [DPA]). So look for products that have more of these.
A chill brain-music interface for enhancing music chills with personalized playlists. It's unusual to see an article on how to experience music that gives you chills in the journal Cell. This tech uses EEG information to create a neurofeedback system that uses an in-ear electroencephalogram (EEG) to create personalized playlists. The EEG-updated pleasure-enhancing playlist elicited more subjective chills and higher pleasure ratings than the pleasure-reducing playlists,
suggesting that adapting music selection to individual neural activities can amplify chills and emotional engagement with music. I'm game to try it.
And I've had this FOMO feeling sometimes, where you think that everybody's getting on the Clawdbot game and you're not, and you must be so behind. Glad to know that I'm not the only person feeling this way, and that it's essentially hype and delusion.
This guy has a clever way of getting around deepfakers who post videos of him saying false stuff. It's not scalable, of course, and it would be a lot easier if he just displayed a hologram containing the date, or something that wouldn't be easy to deepfake. The struggle continues.
Ovarian cancer is indeed somewhat unique in the way it spreads in the abdomen. It spreads like wildfire, taking over the surface structures. Now we know why and it involves TGF-β. Seems that a lot of undesirable conditions in the body are connected to TGF-β.
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Why bitcoin is losing its luster. Gold is better. I think that Trump himself may have hastened its demise. The creation of Trump Coin and Melania Coin revealed to everyone that crypto is just a joke.
Get the homeless off the streets. Make it not worth their while to set up camp in the region. Stop trying to install them in various parts of the city with shelters and rehab centers and crap. It's not working.
Get tough on crime. Jail and prosecute criminals, including the drug dealers and drug users.
Start spending money to the benefit of the actual taxpayers. Clean up the city and make it beautiful again.
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We might be able to see a great comet in April. A Kreutz sun-grazer, C/2026 A1 (MAPS), is on the way. We're long overdue to see one of these. Comet West (1975) was very impressive. Even Comet Bennett (1969) was very nice. It's strange, because another comet, C/2025 R3 (PANSTARRS), is scheduled to make an appearance in April, with a magnitude of 0.4. So will we get two bright comets close together, like Hyakutake (1996) and Hale-Bopp (1997)?
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Do rich people live longer? Yes. Not just because they have better health insurance. They eat better. They have more leisure time to exercise. They're smarter and don't do stupid things and know better how to assess risk and handle it.
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The Search Engine Map. Wow, Bing is bigger than Google. People do rank their search results as being the best now. The Google search universe is smaller – how the mighty have fallen. Competition is good.
Anxiety about the impact of AI on software development is not going away. I'm playing around with Claude Code 4.6 and seems to be very good, although I haven't really given it hard stuff yet to see how much better it is over the previous SOTA model. I agree with Jensen Huang that people are over-panicking. It won't be that easy to clone Oracle, but what it might do is give companies the opportunity to be less dependent on large enterprise solutions. Hard to say what the fallout will be at this time. But the software kings will have less leverage, for sure.
This article says that anti-vaccine tweets caused people to get sick and some to die because they didn't get the vax. Hey, what about the lives saved because people didn't get pulmonary embolism, die of sudden cardiac death, or get turbo-cancer? Did you count those people?
It's important to remind people of the kind of bullshit we were subjected to. Here it is:
But then the Lancet published a meta-analysis which found that all the weird off-target side-effects of statins, such as cognitive impairment, depression, sleep disturbance, and peripheral neuropathy, were not substantiated. So all's good, then?
California universities are spending $17 million to provide ChatGPT for students. That's such a poor way to spend money. It doesn't make them smarter and just sets them up for privacy violations, maybe legal trouble, maybe psychosis, maybe other trouble. Because it likely won't come with a course on how to use it. Better if they got access to a creative suite like Poe.com.
Fat chance. Tina Kotek wants Trump to stop enforcing immigration law. Why? Because illegal aliens are scared. She wants a state governed by the rule of feelings, instead of rule of law. "No one is above the law" is something only conservatives must follow.
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Lloyd Center will vanish into Portland's memory hole. Like a lot of other things, the city can't support nice things. So it'll be torn down. And I strongly doubt it will look like the picture in the article. Add several tents and graffiti on the walls. And there will be no open cafés. Windows will be boarded up. Also lots of trash and people bent over. And everyone will be wearing backpacks.
This recently-published paper is getting attention amongst oncologists. A 60% reduction in cancer mortality just by getting your lung cancer chemoimmunotherapy in the morning instead of the afternoon. It's actually a follow-up study on data this group published a year before, with follow-up going to 48 months. This time it's data from the phase III LungTIME-C01 trial going out to 34 months, and the spread between morning and evening chemo time survival is stark.
OpenAI needs money, and the ads were going to be a way for them to do so. If mockery shuts this down, then what? (Great work, Anthropic.)
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There's been a bunch of writing about what AI means for the software industry. The Fall of the Nerds, for example. Or Death of Software. Nah. I agree that if you already are a stellar software engineer, you will find that these AI tools will take you to the next level. Heck, I'm using them and doing things I never could have imagined doing before. It's like having a personal coding tutor next to you, available at all times. Yeah, there's a price, but it's well worth it.
Lawmakers Mull Dialing Back Funding for Medical Residencies. Wow, so there is money for illegal aliens and giveaways to the homeless, but no less money to give to supporting new medical residents? WTF, man, this is why we will have a shortage of physicians in the future. This is why we pay taxes! Not to have our good money thrown after bad. Supporting graduate medical education is one of the things that the State is supposed to do.
Honolulu is full of eateries. From nice restaurants to holes-in-the-wall. They're everywhere. And now they are feeling the pinch. It's hard to thrive when you live in a Blue state.
I just found out that AT&T bought Quantum Fiber. And with fiber, I can get 2 GB service, better than the 1 GB I am getting with xFinity. And I can get WiFi 7 broadcast, instead of just WiFi 6. Competition is great!
Of course, even those who yearn to visit or live in a walkable, dense neighborhood are not going to flock to a place surrounded by a grim urban dystopia. Efforts to address downtown’s dysfunctions will elicit the usual cries from progressives, who seem unwilling to carry out the necessary policing. But if L.A. and other cities want their downtowns to
survive, this should be the first order of business.
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The Skanner Ceases Operation After 50 Years. It started as news outlet for Black people, just like Asian Reporter is for Asians. I remember people at street corners trying to push the paper on me. But clearly there is a need for investigative journalism, like the kind only WWeek seems to be doing. The Oregonian sure isn't, anymore.
And Washington Post is laying off a third of their workforce. Good! That place was just woke central. I'm glad Bezos is cleansing that institution. Hopefully, it'll be a respectable paper once again. At least less obviously biased.
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Perplexity was my favorite AI tool. Then it started lying to me. Recently Perplexity did hallucinate to me. I had to re-ask the question, and then it admitted that it had fabricated the first answer. But that was just once. I guess it's happening more to other people. Sounds like Perplexity is trying to skimp on services due to being short on cash. It might need to start charging people, or at least charge more for premium service.
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I haven't jumped on the Clawdbot ship yet. I don't need personal AI in my life. So I came across this post, and wanted to see what sort of things I'm missing out on. Check this guy out:
Family document filing. I send a PDF or photo via WhatsApp. Lollo analyzes it with vision-document type, date, sender, amount if applicable. Photos get converted to PDF, then run through OCR. Files are renamed according to a consistent schema (’YYYY-MM-DD [Sender] [Type] [Details].pdf’) and sorted into the appropriate folder. The whole pipeline-vision analysis, format conversion, OCR, renaming, filing-happens automatically.
But filing is only half of it. The retrieval is where it gets interesting. “What insurance policies do we have for our toddler?” “How much did we spend on contractors in 2025?” Lollo searches the archive, reads the relevant documents, and gives me an answer. The documents aren’t just stored—they’re accessible in a way that actually matters.
Personal color consulting. I had professional color analysis done. The results—which colors suit my skin tone, which to avoid-now live in a dedicated skill. I send a photo of a sweater I’m considering: “Does this work for me?” Lollo checks it against my profile and gives me a straight answer. The knowledge persists. I don’t have to explain my color type every time.
Proactive scheduling. Every morning at 7:45, Lollo sends me a briefing: today’s calendar, weather for dog walking times, anything that needs attention. I didn’t ask for it. It just happens. The night before trash collection, I get a reminder which bins to put out. Once a week, I get a summary of local news, filtered by our interests and delivered with a Rhine-region commentary—my wife and I are expats from the Rhineland living in Bavaria, and Lollo knows to add the appropriate sardonic undertone.
Ideas and todos. When I have an idea, I say “new idea about X” and it goes into my Obsidian vault, properly formatted, synced. When I need a todo, same thing. The knowledge doesn’t get trapped in a chat history I’ll never scroll back through. It flows into real systems where it belongs.
Watch history and taste. Lollo has access to my Trakt.tv data-everything I’ve watched, when, how I rated it. Over time, this becomes a taste profile. Recommendations get better because they’re based on actual behavior, not a cold-start conversation.
Meal planning and culinary consulting. Forget smart fridges. I tell Lollo what’s in our pantry and fridge-on the go, via voice, whenever I remember. Not everything, but ingredients that survive a week’s cooking cycle. Based on what’s actually there, it suggests dishes that match our preferences.
Contact management. After meetings or on the go, I can quickly dictate the people I just met. Mixed with photos of business cards, LinkedIn profile links, whatever I have. From this mess, Lollo creates clean new contacts or updates existing ones.
Sheesh. This guy needed a color consultant? My life must be so simple. I put my ideas and todos in a text file that's simple to manage.
A recent article in The Atlantic reported that an increasing number of students at elite universities were claiming they had disabilities to get benefits or exemptions, which can also include copies of lecture notes, excused absences and access to private testing rooms. Those who suffer from “social anxiety” can even get out of participating in class discussions.
What kind of student is Stanford admitting these days? They learn to grift at that school.
Enormous 'mega-blob' under Hawaii is solid rock and iron, not gooey — and it may fuel a hotspot. Oh, I thought this was something new. Every Hawaii student knows about this. That's how the Islands came about. And the iron-rich lava is what makes it flow smoothly and freely, instead of explosively. So we can stand around and watch it up close. It's a rite of passage to step on the lava as it flows and get your rubbah slippah stuck.
"The TSA’s New $45 Fee to Fly Without ID is Illegal," Says Regulatory Expert. I don't understand. Is the TSA supposed to help keep us safe when we fly, or is it just an agency to collect money. I understand that we need ID when we fly (we should nowadays), so what does paying $45 do to make us safer? If I'm going to be stuck in a metal tube for hours with a bunch of strangers, I'd like some assurance that there was some screening being done to check for weirdos.