29 November 2025

If you buy a 3D printer from Flashforge and print a gun, they will apparently cancel your account and will notify "authorites". I can't see anything on their website that says this as of today, and all mention has been only on social media, so who knows if this is true.

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Who knew? You learn about subjects better if you do the search yourself, rather than have a chat model provide you with the summary. 
participants reported developing shallower knowledge from LLM summaries even when the results were augmented by real-time web links
And maybe sometimes what the LLM produces is not factually correct. I've seen that happen before.

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Recent epidemiological and clinical evidence is systematically summarized, linking coffee consumption to reduced risks of chronic liver disease, hepatocellular carcinoma, nonalcoholic fatty liver disease, and chronic kidney disease
Could it really be that easy?

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redistribution and polarization are the lowest in networks with maximum assortativity, where participants are segregated by wealth, and the highest in networks where the rich are most visible. Furthermore, segregation keeps the poor poorest but satisfied, while observing the rich makes them dissatisfied despite becoming better off. These findings suggest that political communication and policy strategies aiming to increase support for redistribution should enhance the visibility of excessive wealth. 
This is why wealthy people would rather live amongst others of their socioeconomic class. Because who wants to live around people that hate you. I've never understood why lefties always demand mixed housing, like Portland does, where a portion of the apartments built need to be for low-income tenants. How does that help? The wealthy are never going to demand to keep poor people away because that would sound heartless. But this study shows why this makes sense.

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There's a newly-recognized form of dementia, called LATE-NC, which stands for Limbic predominant age-related TDP-43 encephalopathy neuropathologic change. It's not rare and it can accompany Alzheimer's disease, making it even worse. In this condition, one finds TDP‐43 proteinopathy instead of amyloid plaques. There's a clinical trial with a drug called nicorandil.

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James Garfield was smarter than your average president.  He even got published in a math journal.

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The Supreme Court Is About to Hear a Case That Could Rewrite Internet Access. May saner heads prevail.

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28 November 2025

The Impossible Prompt That's Easy for Humans. This is Moravec's Paradox. Stuff that is easy for a child is too difficult for advanced GenAI. Here's proof.

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Tattoo Ink Moves Through the Body, Killing Immune Cells and Weakening Vaccine Response. Do you know what's even in tattoo ink? Carbon black, polycyclic aromatic hydrocarbons and azo dyes.  
Tattooed participants had higher risks of skin cancers — including melanoma and squamous cell carcinoma — as well as lymphoma, with hazards rising further for tattoos larger than a palm. In one arm of the study, large tattoos were linked to a 2.7-fold higher hazard of lymphoma and more than double the risk of skin cancer.
What's the attraction with tattoos? You'll look like a funny old person, that's for sure.

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Inhibiting a master regulator of aging regenerates joint cartilage in mice. Apparently, blocking the function of 15-PGDH with a small molecule results in an increase in old animals' muscle mass and endurance.  15-PGDH is a gerozyme due to its increase in prevalence as the body ages, and is a master regulator of aging.

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I had been thinking about getting an Oura Ring, especially as it's being sold at Costco. But now, I think not
For the past couple of weeks, there has been an ongoing uproar from Oura customers following the announcement of a partnership between the wearable smart ring maker, and the U.S. Department of War and Palantir. 
...a spokesperson for Oura tells me that the company has received government demands for customers' data.
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Utility rates up 50% in Oregon. Here’s why.  Short answer: datacenters, taxes, and ill-advised investments in renewable energy. Germany is also learning the same painful lesson.

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An important component of this highway is a region in the center of the brain called the thalamus, which not only helps select which memories should be remembered, but routes them to cortex for long-term stabilization.

The model suggests that, after the basic memory is formed in the hippocampus, Camta1 and its targets ensure the initial persistence of the memory. With time, Tcf4 and its targets are activated providing cell adhesion and structural support to further maintain the memory. Finally, Ash1l recruits chromatin remodeling programs that make the memory more persistent.

“Unless you promote memories onto these timers, we believe you’re primed to forget it quickly,” Rajasethupathy says.

The results suggest that long-term memory is not maintained by a single molecular on-and-off switch, but by a cascade of gene-regulating programs that unfold over time and across brain regions like a series of molecular timers.
Interesting that the thalamus is involved. It's central in so many things.

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This is why Portland is a ghost town.
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Dan & Louis Oyster Bar.  Started in 1907. Survived two World Wars. Survived the BLM riots. Survived COVID-19. But now closing because business is too slow.  Good job, Dennis Wilson. Keep littering the city with homeless shelters. We need more because other states are sending their refuse our way. Yup, 75% are imported.  Come to Portland and get a free house. And shoot up all you want.

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Oregon topped the nation in Thanksgiving family arguments.  The state is always #1 for the wrong things, you notice?

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27 November 2025

The NEJM put out a study last week, which makes it appear that the Pfizer mRNA influenza vaccine is really superior to the standard licensed vaccine. The trouble is, it's only superior in those younger than age 64. In the older population, which is those more likely to suffer the consequences of having influenza, it was no better. The NEJM editors should have caught that, but they didn't. And even regular influenza vaccine doesn't always help. Last year's version actually increased your chances of getting the flu.

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MIT study finds AI can already replace 11.7% of U.S. workforce. I always take these studies with a grain of salt because it's really hard to gauge this, and things change constantly.  But it doesn't bode well for people in the short term. Better develop new skills. 

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Do you want a foldable iPhone? Not really. I'm happy with what I have. The price point is too high. And I just know it's going to break.

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So Dennis Wilson is going to reach his goal of spewing 1500 shelter beds around the city.  Big deal. There will still be plenty of drug-abusing homeless on the streets. What a grand waste of money. Not solving the problem, Dennis.

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26 November 2025

Amazon Leo UItra is the new rival to Starlink.  It'll be faster, too, capable of 1 GBps instead of the max 380 MBps with Starlink. It'sll probably cost more, though. Doesn't start until sometime in 2026. What will Elon do in response?

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Netgear is also rolling out a new Nighthawk MiFi modem that reached 3.6 Gbps. I'm not sure if my wireless carrier will support this. Looks like you gotta sign up with Airalo. That's too bad.

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First, a former physician used his personal email address in a meeting group, contrary to hospital policy. Second, the meeting organizer did not remove the physician from the meeting invite following his departure in June 2023, according to the Information and Privacy Commissioner of Ontario.
As a result, when the physician installed Otter.ai on a personal device in September 2024, the transcription tool was able to access the rounds meeting invite via the physician's personal digital calendar.
...it wasn't clear whether the physician even realized the Otter.ai bot had attended the meeting on his behalf and recorded it – or whether it had done so for other meetings as well.
“That’s a whole level of autonomy and independence that we haven’t been prepared for but need to start thinking about,”
This is a new vulnerability. It's not going to be just healthcare, but every virtual meeting where confidential matters are discussed.

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I just thought this was a sneaky way for a Chinese app to get all sorts of personal information from you. Well, at least the developer tells you:
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Beware of AI slop Thanksgiving recipes.

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GPT-5 is the best predictor of the future.

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Elon Musk Drove ~1/3 of Women Off Twitter. Well, I think X is much better now. It's more balanced now that conservative voices have a say and are not automatically censored, like back in the Trump 1.0 days.
Check out the New Must-Have College Admissions Skill: Tolerating Other Viewpoints.  

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Data center provider razes 55 homes to make room for Illinois campus. Sign of the times. And then, there is Oregon. "‘The precedent is Flint’: How Oregon’s data center boom is supercharging a water crisis."
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Daily coffee drinking may slow biological aging of people with major mental illness. But why just those with mental illness? Drinking up to 5 cups lengthens telomeres, and gives you "the equivalent of 5 extra biological years". I'll take it.

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Brain changes observed during pregnancy. Yup, I've noticed it.

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The gruesome new data on tech jobs. I remember during the dotcom era, techies were SO desirable. They were millionaries. Now, they are struggling to find a job and a sense of self-worth, with feelings of doubt and perhaps betrayal.

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Southern Oregon is the canary in the coal mine. Actually many of the coastal towns in Oregon are. Sucks to be in a Blue state, when the rest of the country is doing fairly well, or at least is not hurting. Oregon had seemed like it was doing OK, but it was all due to federal subsidies. Paying for this and that. Plus illegal immigrant labor. Now that's all gone, and Oregon is suffering. It's painful, but a cleansing is overdue.

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25 November 2025

Americans are holding onto devices longer than ever and it’s costing the economy. Costing the economy? You gotta be kidding. One reason not to buy a new phone is the hassle of transferring everything over. Sure Apple has made it easier, but you often have to re-login and enter credentials for apps again. And newer phone aren't that revolutionary in what they offer. I've haven't noticed my photos being that much different.  Offer Tony Stark's phone and I might consider it.

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Quick – what's the largest city in the world?  Tokyo, you say? Nope. It's Djakarta.  What's #2? Dhaka, Bangladesh. In third place is Tokyo. Then New Delhi, Shanghai, Guangzhou, Cairo, Manila, Kolkata, and Seoul. What does this tell you about the future of the world?

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Tina Kotek is now worried about the price of gas because of what the Olympic Pipeline leak might do, in terms of a shortage. Maybe you could halt the gas tax, Tina? Afraid that people will revolt at paying $5 per gallon for regular?

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Cheetos and Doritos will be sold without artificial dyes and without the powder that we've all come to expect. Doritos will look like regular tortilla chips. Still won't be considered "healthy" for you. 

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Is kimchi good for your immune system? This paper suggests that it might be. I think if you can eat it and survive, your body must be especially tough.

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Another paper says that there are changes in your body at certain ages. This paper is focused on the brain, and says that ages 9, 32, 66 and 83 demarcate distinct cognitive eras. You know, I have noticed changes since being an older ronin. I'm less tolerant of B.S. now and less anxious about things. I don't worry as much about the future. I think hormonal changes in puberty certainly have an effect and would mark a change at age 14 for boys and age 12 for girls. Certainly at menopause, women think differently. At age 83, your brain is showing the effects of all sorts of things: alcohol, chronic stress, head injury, your education, how much you cultivated learning things and maintaining interest, and overall physical activity.

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Gallup ranked states in terms of how excellent they are in healthcare, and what surprised me is how uniformly lousy they all are. There's not much difference in quality of healthcare among all the states – they're all about the same. This actually makes me doubt the quality of the ranking methodology. Healthcare in certain states (like Texas, Massachusetts, New York and California) definitely have access to quality care. They suffer from other things, but quality in a few states are definitely better than others. Oregon is near the bottom (as usual) and even with OHSU, the state got a C grade.

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So funny. Katie Wilson is now thinking she would meet with Trump if he asked her. No, Katie. Trump met with Mamdani because he asked for the meeting and Trump has interests in NYC.  He has no interest in Seattle. You're on your own.

And Seattle is ending their program supplying crack pipes and tin foil to the homeless drug users. I bet Katie Wilson will restore it, though. 

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Phil Knight gave $3 million to help elect Republicans to Oregon government.  As long as we have mail-in balloting and ballot counting over several days after election day until the preferred candidate wins, that will never happen. Don't throw good money after bad, Phil. Oh well, it's not my money.

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"After an extensive national search" OHSU Health hired a CEO. It's always an outsider – no one internal either wants the job or has enough support from colleagues. This guy came from a Kaiser hospital in the Bay Area. Kaiser isn't known for excellence in medical research, but perhaps he'll know how to save money for the hospital.

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24 November 2025

Hayli Gubbi volcano in Ethiopia erupts for the first time in recorded history. Mount Semeru erupted recently. The volcanos are waking up. It's far away, but somehow this disturbs me.

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Let's talk about the Asian experience in the US throughout history. Heh, not the guy I thought would be discussing something like this, but we can't judge by appearances, can we? It's true. Asians have been discriminated against for a long time. I don't think that Trump is discriminating against Asians. I think he's just concerned that China is a dangeous economic threat to the U.S., which is something that previous administrations (think Obama) neglected to consider in their drive to globalization. Witness Trump's embrace of the Japanese PM. However, I am disappointed that his online swag shop had hats with "Blacks for Trump", "Women for Trump" and a variety of other groups, but never had "Asians for Trump". Forgotten again.

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Wisconsin and Michigan may pass laws banning VPNs, just so they can force their age-verification policy. I've always said that the Internet is just not a place for children, even though people want to get children online. Forcing age-verification is violating online privacy. And there will be other ways to get around this. Politicians were never the brightest bulbs.

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Study shows that California loses a taxpayer every 1 minute and 44 seconds.  For New York, it's 2 minutes and 33 seconds, and this is data from before Mamdani won the election. I predict it will be the same situation for Seattle. It's already something like this with Portland.

And for those who stay in Seattle, juggling two or more jobs isn’t just for low-wage workers. Hope you love your socialism, Seattle-ites. Good and hard. 

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Seattle and Portland are amongst the heaviest users of cannabidiol. Are people in so much pain in the Pacific Northwest, or have epilepsy? One wonders.
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Verizon is cutting 165 jobs in Washington state. Layoffs start in late January. Holiday season bummer. More tax base reduction and business contraction. 

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23 Novemnber 2025

Turn a cluster of Macs into an AI supercomputer in macOS Tahoe 26.2. The catch is that you will have to have a computer using the M4 or M5 chip that is capable of using a Thunderbolt 5 cable. I figured there'd be a catch.

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Mayor Keith Wilson is dead set on opening a lot of overnight homeless shelters. The problem is, many of the shelters are on average, less than half full. So what's the point? This seems to be a grand waste of city money to fund the operation of these shelters, when the homeless aren't using them.

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22 November 2025

China Just Invented the Battery That Will Kill Gas Cars. It's "next-generation" lithium batteries. I keep reading about these batteries, but don't see anything in production yet. A case of over-excited reporters?

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Open Access is no more. This is unfortunately, although to be honest, whenever I tried to use the button in my browser, I didn't get access. The button didn't work. The Unpaywall button does work, though, and it's still working.

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Arginine supplementation curbs Alzheimer's disease pathology in animal models. Interesting theory, but I doubt it's that simple. Paper here. It's a Japanese paper, but I still think that this experiment isn't going to be reproducible. We'll see if arginine supplementation is the cure we've been looking for.

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How embarrassing. Oops. Cryptographers cancel election results after losing decryption key. This is exactly why elections should be low-tech. Keep it simple. Paper and pen. Forget fancy cryptography.

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I came across this article stating that Markdown is not always suitable for technical writing. I think that there is truth to this. Markdown should be a format that computers (LLMs especially) should write in. But for humans? I find it too cumbersome. Humans just need a WYSIWYG editor that saves in RTF format. But I also came across this nice list of Markdown editors that someone bothered to compile. Not too long ago, I did a web search to find the best Markdown editor to see if there was an editor that would make it easy to use this format. All I got were websites of various editors, but not one that reviewed and showcased them all, like this site. This shows how the best search engines still don't get everything.

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Thanks for reminding me why I stopped using Firefox.  By the way, LibreWolf finally updated to 145.0 and you don't need the --no-quarantine parameter. I think the developer finally bought himself an Apple developer account and signed the software, so now
brew install --cask librewolf
just works. Apple has announced that the --no-quarantine parameter wasn't going to work after August 2026, so it's about time.

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Scientists create new bullet-proof fiber that is stronger and thinner than Kevlar. This is thinner than a human hair, and it stops bullets? Really? But it's Chinese. When are we going to develop something like that here? Still, I bet this will be a hit in the UK.

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The privacy nightmare of browser fingerprinting. There's not much you can do about it. I like the Brave approach, where it makes up random fingerprints so that you're never the same. I wish other browsers would adopt this approach. Mullvad sort of works, but not quite.

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Why it takes months to tell if new AI models are good. He's talking about LLMs, of course, not referring to all AI. So take the initial reviews with a grain of salt. Try it yourself and see.

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21 November 2025

125 interesting biology links.

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Norway was feeding Bovaer to their cows to reduce cow farts. And the cows were suffering. Now they are stopping this, learning a lesson from the Danes.  But it's not even cow farts that produce most of the methane. It's their belching. And a significant contributor is the settling ponds and lagoons that process their manure. 
But why are we worried about cows when humans produce 60% of all methane emissions? Not from farts, but from everything humans do. Human wastewater represents 14–20% of total methane emissions. Vegans fart more than those following a typical Western diet.  So it's crazy to make cows miserable for the sake of reduced methane emissions. This is the kind of insanity that makes people not take liberals' concerns seriously.

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The game Zork is now open-source. This ronin spent a lot of time playing Adventure, which is like Zork. But now, as an older guy, this is bittersweet news.

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Oregon's school chronic absenteeism is the among the highest at 33%In 2022-2023 Oregon was the second highest. Even in Lake Oswego, the percentage of those chronically absent from school is 18%. That's embarrassing.

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Dave Ramsey pointed out the flaws of Obamacare in 2016.  It's even worse today.

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20 November 2025

Light magnetically influences matter? Yes it does. What can be done to exploit this?

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Rare brain cell may hold key to preventing schizophrenia symptoms. Does this brain cell appear when who have a pet cat?

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Ringit could be useful. It makes your phone emit a loud ring, even though it's on silence. Could be abused, though.

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CreepyAI tech is making mind-reading no longer science fiction.

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One of the fastest growing AI universities in the world is the Tsinghua University in Beijing, China. 
Tsinghua has produced more of the world’s 100 most-cited AI research papers than any other school, and the university generates more AI-related patents each year than MIT, Stanford, Princeton and Harvard combined. Between 2005 and the end of 2024, Tsinghua researchers filed 4,986 AI and machine-learning patents—including more than 900 last year
And they don't have to worry about DEI initiatives of pro-Palestinian protestors cancelling lectures. 

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A stretchable bandage like finger cover may allow haptic feedback. It's called VoxeLite.

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OpenAI launches Codex-Max, an AI that can code on Its own for 24+ hours straight. Talk about energy consumption. Who pays for this? How many people need something like this?

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The experimental TMSR-LF1 thorium-powered molten salt reactor in Wuwei, Gansu Province, has achieved the first successful conversion of thorium-uranium nuclear fuel, the Shanghai Institute of Applied Physics of the Chinese Academy of Sciences announced.

"This design not only improves fuel utilisation but also significantly reduces the generation of radioactive nuclear waste, which is one of the advantages of thorium-based molten salt reactors."
This is what we need here.

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Gary Marcus thinks that Yann LeCun needs to be taken down a peg. I didn't know that convolutional neural nets were actually invented by Kunihiko Fukushima in 1979-1980, and that adding backpropagation was actually invented by Wei Zhang and colleagues in 1988.  All the stuff you read credits LeCun. I felt bad that he didn't get the Nobel Prize, but now I guess I don't.

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Holy crapPortland isn't building very many luxury apartments anymore. Construction is WAY down.
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67% of Oregon voters think the state's economy is on the wrong track. I'd like to know why the rest think it is on the right track. Who in their right mind would think so?

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Homeless in the Portland area has increased by more than 60% since 2023, despite all the efforts to reduce it.
Doesn't anyone care to think that maybe a change in strategy is warranted? We've tried it this way and it isn't working. Let's listen to the conservatives and see if their approach might be more successful. How about that?
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"We've had the highest number of management positions within TriMet's personnel than we've ever had with the lowest number of employees that we've ever had."
Who rides TriMet anymore? Would anyone want to sit in those chairs? You never know what you might sit on. One of the commenters is prescient. Notice the use of the word "positions" that are being cut? It's probably a reduction of open positions rather than any union member being laid off.

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Portland wants to ban the use of AI software that landlords use to calculate setting rent. And the landlords are not happy. As usual, Portland city council see the word "AI" and goes nuts. This is not dissimilar to using a spreadsheet. Robots aren't setting the rent. It's just a deep learning protocol. 

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