A new study reports that a triple-targeted drug combination can drive complete and lasting regression of pancreatic tumours in preclinical models, potentially overcoming treatment resistance in one of the deadliest cancers.
Researchers at the Spanish National Cancer Research Centre have announced a potential breakthrough combination therapy that induces complete regression of pancreatic tumours and prevents tumour resistance in preclinical models.
Paper here. The drugs they used were:
- RMC-6236 (daraxonrasib): targeting KRAS
- Afatinib: an EGFR family inhibitor
- SD36: a selective STAT3 degrader
Maybe Earth will have a ring in my lifetime after all.A "close approach," defined as two satellites coming within less than 1km of each other, happens about once every 22 seconds. Within the Starlink network alone, this occurs roughly every 11 minutes. To avoid collisions, each Starlink satellite must carry out an average of 41 course corrections every year.
Solar storms can interfere with or disable satellite navigation and communication systems altogether. When that happens, satellites may be unable to respond to threats in their path. Combined with higher atmospheric drag and increased uncertainty, this loss of control could quickly lead to a serious accident.
The most widely known outcome of widespread satellite collisions is Kessler syndrome. In this scenario, debris from collisions accumulates around Earth, making it nearly impossible to launch spacecraft without them being destroyed.
Celibacy taught me I’m too clever to find love. Too clever? No wonder his girlfriend ditched him.
And speaking of people who get burned using tech that they don't fully understand, here's a three-parter on those who jumped onto the Clawdbot craze.
When reliability engineering is done well, nothing bad happens. When nothing bad happens, it looks like nothing is being done at all. But it takes a lot of work to make nothing happen!
That package, if passed by the council, would dedicate $8.5 million to rent assistance, $1.2 million to tenant eviction defense, and $1.4 million to “affordable housing portfolio stabilization tactics.” Another chunk of the money would provide gap funding for ongoing affordable housing development efforts.
Sigh. Portland is run by a bunch of schoolkids.“I’m frustrated by Mayor Wilson’s whining,” Councilor Loretta Smith said. “When he doesn’t get everything he wants, he goes out into the public and whines about it.”
Turns out the vaccine induced the presence of T-cells positive for CD27, seen on natural killer cells. That's probably the mechanism. So now, they're going to see if they can pick up where they left off and improve it. I'm used to reading more about CD28 and checkpoint inhibitors, so this is new.“We were stunned to see such durable immune responses so many years later,”
A 2024 study of ~112,000 people taking cognitive tests found that even short, mild COVID infections were associated with small, but measurable, cognitive deficits after recovery (a loss of about 3 IQ points). Severe cases requiring intensive care were associated with much steeper deficits (corresponding to a loss of -9 IQ points).
“I think it’s OK for nurses to make close to $200,000, just to make a livable living in the tristate area, honestly,” said Ms. Roy, who lives in Bergen County, N.J., and pays about $30 in tolls and parking each time she comes to work.
In the New York metropolitan area, a family of four with two working parents needs pretax income of about $145,000 to cover their cost of living, compared with about $112,000 in Miami and about $105,000 in Houston, data compiled by the Living Wage Institute show.
Nurse practitioners in New York earn more than their counterparts in every city in the country with the exception of Bellevue, Wash., according to data compiled by Indeed, the online job site. Indeed shows nursing jobs in New York pay about $142,000 a year, about 9 percent higher than the national average of about $130,000.
Nationally, the median annual pay for registered nurses was $93,600 in 2024, according to the Bureau of Labor Statistics.
Trump’s rise was fueled in part by the perception that liberal elites advanced unpopular policy agendas without seriously considering dissenting arguments. Because liberals protest more than any other political group, every additional protest that isn’t accompanied by rational conversation just endorses the image: We are the rowdy, unthinking kids uninterested in genuine engagement, more than happy to take refuge in numbers.