13 January 2026

A pill to treat sleep apnea? Apparently it stimulates the brainstem to regulate breathing while asleep. It would seem to be a treatment for central sleep apnea, but the article suggests that it works for obstructive sleep apnea, too. The company is Apnimed. They could make a lot of money – sleep apnea is so common.

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Sad day. Scott Adams passed away.  He made an indelible mark on life, no question.

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The unexpected interaction between CBD and THC in caffeinated beverages. Apparently THC, CBD and caffeine interact and can make you feel overconfident, even though you are impaired. 
This method was designed to model how a consumer might slowly drink a cannabis-infused beverage at a social event.
The total dosages administered were 7.5 milligrams of THC, 180 milligrams of caffeine, and 105 milligrams of CBD. These amounts were selected to reflect the potency of products currently available on retail shelves. 
When participants consumed the THC and caffeine mixture, they expressed a slightly higher willingness to drive compared to when they consumed THC alone. This increased confidence occurred despite the fact that their actual driving performance on the simulator remained impaired. This disconnect suggests that caffeine might mask feelings of sedation without restoring the physical and mental skills necessary for safety.
Paper here.

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Physicians see 1 in 6 patients as ‘difficult’, particularly those who have anxiety or depression. I can imagine. There are other articles describing how more doctors are leaving medicine than ever before.

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Stoicism is one of the best mind hacks ever devised. It will definitely help you deal with stress.

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This Ralph Wiggum hack started out as a joke, but it's becoming big.

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Taiwan now takes the lead in the country with the lowest fertility rate. What's with these Asian countries: Japan and South Korea and now Taiwan. No one ever accused mainland China of having a fertility problem. What's going on?

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Phind.com is shutting down.This was my very first experience with chat models. I've moved on to better things now. Looks like phind.com never really grew out of their original business model. No wonder it had to shut down.

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Maybe I'm going to have to get a new monitor. Some of these at CES 2026 look sweet.

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‘A 9-gigawatt problem’: Northwest’s soaring energy demand, supply constraints, could spark new power crisis. Oregon's power consumption demands are taking off, but the infrastructure and how to pay for it is lagging behind.  This takes savvy management by someone who knows what to do. And who do we have? Tina Kotek.

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Google removes some AI health summaries after investigation finds “dangerous” flaws. Dr. Google realizes that giving medical advice is complicated.

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The Oregon Scorecard. Gonna bookmark this. Oregon's scores are low, and is the reason why we're in the fix we're in. Seems all the government knows how to do is get federal subsidies for this and that and to tax people and collect fees for the rest.

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Gavin Newsom moves to neutralize tax on billionaires. Good luck on that. Once this gets on the ballot, Californians will all want to "stick to the rich". And once it's in place, it will be renewed. It won't really be a one-time thing. They'll extend it, no doubt. And Newsom won't be able to do anything. The Google guys did right to move out. 

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12 January 2026

Anthropic is getting into the healthcare business, too.  Looks like the initial foray is in prior authorization approvals, which can streamline the process. 

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Heart failure deaths have accelerated in U.S. since COVID pandemic. Whatever could the cause be?

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Here's a new way to think about how LLMs should process memory. Make them memorize things like how humans do.

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It's funny to see two separate articles talk about the same thing: how lousy Date() is in javascript, and how Temporal() is going to replace it. Seems like something long overdue.

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This guy used AI to find a really good secret fishing spot. He scraped 100,000 fishing posts and put all the information together to narrow down the location. Excellent use of technology.

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There's a right way and a wrong way to detach Post-It notes from the block.

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This guy calls himself a security expert but he uses the Chrome browser. And he installs extensions without knowing what they do.

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AI can perceive optical illusions now. So perceiving them is not a human brain characteristic, is it?

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Microsoft seems to be a bumbling company now. I thought things were bad during the Ballmer years, but those were mainly bad tech decisions – missed opportunities and bad implementation. Now, it's indecision (esp with AI) and bad marketing. Office is their bread and butter. What are they going to do if people start abandoning it for something more predictable and doesn't waste time on stuff people didn't ask for?

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Sign of the times. In China, young people who live alone seem to need an app that will let others know if they die. If they don't check in at least every two days, notifications get sent out.  To notify those who you think would care to know. How pathetic that is.

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Erich von Däniken died two days ago.  I read Chariots of the Gods when I was a kid. Had a lot of discussions with my nerd friends. RIP, man. You were the first (at least for me). Then came Graham Hancock.

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11 January 2026

Cool. Japanese scientists have developed a new kind of microscopy that lets scientists observe life unfolding inside cells. It's called bidirectional quantitative scattering microscopy (paper here). This lets you see the traffic in a live cell and gain insights into cell biological functioning.

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Testimony from a surviving Maduro guard on what happened on the night of the raid. Sounds straight out of some science fiction story, if his account is accurate. 
Without a doubt. I'm sending a warning to anyone who thinks they can fight the United States. They have no idea what they're capable of. After what I saw, I never want to be on the other side of that again. They're not to be messed with.
Looks like gave 5 stars on the mobile app. Looks like the U.S. really has a Department of War. 

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By playing around with the molecular structure of LSD, some scientists found a potent analog to treat depression without the hallucinogenic potential. It's called JRT, and since it's unusual to have the letter J in a scientific name, I clicked to see what it stood for. It stands for the initials of the lead author. He named this agent after himself. 🙄 That's different. 

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Today is the day Aaron Swartz died in 2013. One of the things he invented was the Markup Language. And this article from last year appeared today on Hacker News. Of course, people are opinionated about this, and the author took umbrage at criticism directed against the article. Markdown is not perfect, but there is a place for it. and we need some kind of simple formatting to achieve a WYSIWYG look. I edit in CotEditor and view the result in Marked 2. I don't think Markdown is a "disaster" but it's there, and you can use it if you like, or leave it alone.

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It's so amusing when media publishes articles like this: The NIH has lost its scientific integrity. So we left. The authors are upset because RFK Jr is having the vaccine schedule reviewed and updated, and apparently they don't like that this happened at all. You never saw articles like this when Biden was president and they kept pushing the COVID mRNA vax product. Or when the Dems were so much in favor of sex-reassignment surgery on teens. Yes, somehow reviewing the vaccine schedule is scientific dis-integrity? This just reveals how partisan they are. 
And speaking of the Lefty intolerance, I lost respect for Daring Fireball after he posted this article, calling Sundar Pichai and Tim Cook cowards for not censoring Grok. The Right says, "If you don't like it, don't use it." The Left says "I don't like it, so you can't have it." There are far, far worse things that society has had to put up with during the last administration than just an app that puts a bikini on people.

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This is the hard reality of the downside of biometric security. We saw this in Dan Brown's book Angels and Demons, too.

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There's been social media buzz that maybe high cholesterol levels are actually better for you. This article debunks that. And I love this quote:
“We must admit that our opponents in this argument have a marked advantage over us. They need only a few words to set forth a half-truth; whereas, in order to show that it is a half-truth, we have to resort to long and arid dissertations.”

― Frédéric Bastiat
So true.

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I saw this article: How rethinking your relationship with time could give you more of it, but this statement caught my eye:
One study showed that people would rather spend 15 minutes getting electric shocks than 15 minutes of time with their own thoughts – particularly men: 67 per cent of men preferred the electric shock, compared with 25 per cent of women. 
I can relate to this.

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Do you feel this way?  Using AI is no longer optional. It's beginning to feel that way.

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Yet another article touting the value of creatine supplements. Increasing levels of creatine should help in theory but I never notice any difference. Like I don't get that post-exercise mood elevation people talk about.

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It's simple (in theory). How to get stronger – keep exercising until your muscles ache, and always be working on trying to make them ache.

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The Economist write about falling fentanyl overdose deaths.  But do they credit the current administration? Nope. They do admit that peak purity of fentanyl powder occurred in July 2023 (while Biden was in power) but what they credit now is that somehow there is "shrinkflation" keeping drug overdoses low. What effort could have resulted in that? Could it be "something changing in China"? Hmmm. They are at a loss to say.

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Sigh. Gov. Tina Kotek extends homelessness emergency for fourth year.  Of course.

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10 January 2026

Most Alzheimer's cases linked to variants in a single gene. And that gene is ... APOE, coding for apolipoprotein E. Why would that be? What's the connection?

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Origin cells for common malignant brain tumor in young adults uncovered. It's amazing that before, the presence of an IDH1 mutation in glioblastoma was felt to be an occasional marker and perhaps something that could be used as a targeted treatment. Now, the presence of an IDH1 mutation means that a tumor is NOT a glioblastoma, but rather a grade 4 astrocytoma.

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Infections can be diagnosed in 20 minutes. This is not really news, as it's been reported before. I'd like to see how this pans out in real life. Sometimes infections can be polymicrobial, and so detection of only the lead bacteria can lead to unexpected outcomes. Still, it's an advance, and certainly welcome.

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Always learning something new. How Dad’s Fitness May Be Packaged and Passed Down in Sperm RNA. Sperm donors don't pass on these traits since mRNA is too fragile to survive the storage process. Even one of the researchers said "“It’s still very hand-wavy.” The idea is that certain aspects of a father's fitness might be passed on through microRNAs is intriguing, though.

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5 letter word finder.  Could come in handy. Who knows?

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Having a million word context window may not always be a good thing.  It's called "context rot" and appears when models are given too much context. Even frontier models degrade on tasks like knowledge retrieval. There is context dilution with longer windows. Apparently that final softmax function becomes less reliable when there so many datapoints. It's kinda like with the human brain. Even LLMs stumble when given too much information to chew on. Positioning also matters. Put critical information at the start and end of the query, use RAG for very large corpora, and consider chunking with summarization for documents that exceed reliable limits. Good to know.

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How hackers are fighting back against ICE surveillance tech. I must admit to being conflicted. I don't like surveillance tech, but it's been around for years ever since the Patriot Act was passed and no one complained. Yet people are complaining now because it's being used to identify illegal aliens. That I don't understand. It's a fact that the U.S. has let in a large number of bad boys and we need all we can use to track them and get them out of our society. That's just common sense. Why hackers are opposed to this is baffling. Who do they think they are protecting?

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One prediction shared by several Lorentz-invariance-violating quantum gravity models is that the speed of light may depend slightly on a photon's energy. Any such effect would have to be tiny to match existing experimental limits. However, it could become detectable at the highest photon energies, specifically in very-high-energy gamma rays.
Nope. No observed difference in the speed of light. Einstein is still right.

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Washington state officials have issued a correction after they were caught exaggerating the benefits of state spending to curb climate change. In November, a report from the Washington Department of Ecology said the first two years of auction proceeds would keep more than 8.6 million metric tons of pollution out of the air.

“That’s the equivalent of taking 40% of all gas and diesel vehicles in Washington off the road for a whole year,” an Ecology press release stated.

Yet that claimed carbon benefit was 28 times higher than the reality. According to revised calculations by Ecology, the projects will only keep about 300,000 metric tons of heat-trapping gas out of the air over their lifespans.

That’s less than one-half of 1% of the state’s annual emissions.
It's all B.S. and I'm surprised that the left-wing OPB actually reported it. I guess Katherine Maher's influence is already gone. 

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9 January 2026

Sergey Brin is also leaving California due to the billionaire tax. Unclear how much of an impact it will be to California, but the more people that move out and establish another center of excellence the greater the chances that this will set off a cascade. Unfortunately, Stanford University, the source of all of the brain power and excellence, isn't moving. It's too late for the other billionaires who haven't made the move. The retroactive part of the law is the killer. 

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Do we emit light while we're alive? Sounds kinda like research that isn't going to be reproducible and will be forgotten later on.

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Are we on WiFi 8 already? My devices are still on WiFi 6E. I'd be happy with DOCSIS 4. When's that coming? Xfinity has been promising that since 2024 and it's not here yet.

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Collected Papers of Albert Einstein now available at Princeton. It'll cost you, though.

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This makes more sense. Long COVID may be fueled by inflammation and tiny clots. There may be some improvement with some of the medicinals discussed. And yeah, getting a vax booster did not help, contrary to earlier reports.

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Gemini-3-Flash is da bomb!  I've been impressed with the Gemini models. There is a preview model that has a free tier. That's the one I'm using.

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If you want to build personal agents, you don't need fancy platforms like N8N. It can be really simple with Claude and a Claude.md file which houses your instructions.

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Portland video journalist explores that ramifications of datacenter building in Hillsboro and North Plains. Seems like the civic leaders are trading short term gain for long term misery for citizens.

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Is America falling out of love with pizza? It's probably all the people on GLP-1 RA drugs.

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Man, is WHO chief Dr Tedros Ghebreyesus still in office? Haven't they kicked him out yet? Now he says that masks are ineffective. He wants respirators everywhere now. Yeah, fool me twice, will you?

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Apple Loses Safari Lead Designer to The Browser Company. What's going on at Apple? They're hemorrhaging people. Apple used to be the world's most valuable complany. Now Alphabet has surpassed Apple.  The company has no credible AI pathway forward. "Thinner with more pixels and emojis" isn't working anymore.  Tim Cook should step down. Enough already.

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People in Brazil are living past 110 and scientists want to know why. What's the secret to their longevity? Bad record keeping, too? Or is there really something to it?

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8 January 2026

Interesting insights into LLMs: AI isn't just "predicting the next word" anymore. But is it truly capable of understanding?

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OpenAI has launched ChatGPT Health. This is the reasoning behind it. All very noble-sounding, but the solution is not going to be what is being offered. Even Axios recognizes the privacy risk. And this article really nails it down. OpenAI doesn't really intend to replace the doctor. They really want your health records, despite what they say. It's not. a HIPAA covered entity like a real physician, so whatever you volunteer to give up is fair game to them. And it's telling that they don't offer this in Europe, where data privacy protection is strict. What does OpenAI have to hide that they can't meet European standards?

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Exercise may relieve depression as effectively as antidepressants. I've never experienced any kind of mood elevation after exercise. Just exhaustion and fatigue.

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Why sports stars who head the ball are much more likely to die of Alzheimer's, Parkinson's and motor neurone disease. Your brain is something you want to protect, as it determines more than any other organ, what kind of life you will lead. Alzheimer's disease? Parkinson's disease? If you can avoid it, why not do so?

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Familial natural short sleep. Wow, it's like a super power. Not needing as much sleep but not experiencing any ill effect. These people can probably clear their CSF of waste products more efficiently. And better memory, too! The data suggest that this is a polygenic phenotype, so inheritance is not simple. You just have to luck out.

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Japanese scientists have discovered a new large virus, the ushilkuvirus, which fortunately only attacks ameba. It sure has a pretty icosahedral shape, kinda like the head of the bacteriophage virus. 

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UCSD is really messed up.  How your high school affects your chances of UC Admission. In their desire to be a DEI school, they've really hurt the quality of what a university education is all about. It's no longer a bastion of advanced academic excellence. It's a vehicle for trying to force an fairy tale equality outcome on the hard realities of inequality.

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OHSU says they paused "gender-affirming" surgery for patients younger than 19. Note that they consider it "paused" and not discontinued. Monsters.

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Tina Kotek now wants to scrap the entire transportation tax bill. Some think it's because she wants to get rid of the good parts, but I think it's because the initiative is going to appear on the November ballot alongside her re-election bid. And it'll remind people what an awful governor she is.

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7 January 2026

We've all been there.  "It usually starts quietly. A thought arises unexpectedly, linked to something unpleasant, and the body responds before before the mind can catch up. For persons who have experienced experienced trauma or anxiety, this pattern might continue for many years." Well it may be possible to erase the impact that bad memories have with a new technique that involves planting positive memories during sleep. It's a memory editor that awakens positive memories during sleep. Paper here. 

"participants learned associations between half of the words and additional positive images, creating interference. During the following non-rapid-eye-movement sleep, auditory memory cues were unobtrusively delivered."

Does it really work? Probably not that easy but it's an interesting insight.

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Larry Page is leaving California after all. Guess he doesn't like Democrat rule that he supported after all. Wherever you go, Larry, don't bring your Democrat votes with you.

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Will Kathleen Kennedy leave the Lucasfilm division of Disney? Oh, man. It's not too late.

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Woah. Microsoft OneDrive steals and deletes your files?

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The Ralph Wiggum plug-in apparently makes your code much better.

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Oregon quietly registered non-citizens to vote — and only now admits the mess. That was a feature, not a bug.

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Oregon economist paints mixed 2026 outlook:
In terms of employment, Riccadonna said jobs are increasing in the health care and service sectors but declining in construction and manufacturing. 
Yeah, more jobs are going to sectors that require subsidies to thrive. For those jobs that actually make money, we're not seeing jobs.

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6 January 2026

Dramatic drop in Stack Overflow questions as devs look elsewhere for help. StackOverflow is like Chegg now.  At one time, we put up with all the lousy posted answers, because that's all we had to work with. Now, those days are gone.
Here's a viewpoint by a former StackOverflow user.

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Transcranial electrical brain stimulation to treat depression has hit the mainstream. A device for home use is now FDA-approved. This is good because mental health ratings in the U.S. hit historic lows. 

I thought about this in reading that Sen Ron Wyden is in support of rescheduling cannabis to a Schedule III drug. 

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Trump Cannot Slash NIH Research Funding. As I recall, the two issues were grant funding for DEI-related projects. Under the Biden administration, including woke language was done to increase chances of getting funded, because that's what lefty grant reviewers were looking for. Of course, such verbiage is now a liability under Trump. The second issue was the high percentage of indirect costs which universities were taking to put into their slush fund. The argument about using endowment money was likely a suggestion, not a contingency to justify the decrease in funding. But I do agree that cutting back on science grant funding should be a last resort. Researchers can't help it if Democrats run the show sometimes while Republicans run it at other times. You gotta go with the flow. And they can't control indirect cost requirements either. Trump should continue funding science and focus on the much greater fraud that's going on. That will save us money!

Update (8 Jan 2026): Appeals court says that OHSU must be paid NIH money.  The 56% indirect cost figure is obscene. This is what the Trump Administration has been arguing, and rightly so. That's just abuse and indirectly hurts researchers, who end up getting penalized by working at universities which demand so much. 

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Don't wait until the last day. USPS is now postmarking letters and packages based on when they are processed at a mail facility, not when they are dropped in a box -- meaning something mailed on deadline day could receive a next‑day postmark. You can always go in and have a postal worker timestamp it for you, though.

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I just learned that in Washington state, it's a misdemeanor crime to knowingly give someone a cold and also to knowingly expose yourself to a sick person to get a cold. Gee, was there some kind of work-avoidance scam going on, or something?

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Washington has the lowest business survival rate in the nation. Wow, worse than Oregon. And it's probably due to stuff like this: Seattle in freefall under hyperwoke mayor as new order allows drug users to avoid prosecution... with homeless encampments growing in city. Mayor Katie Wilson is in competition with Mayor Zohran Mamdani to be the most incompetent and destructive mayor of a major American city.

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Lawmakers call to help secure rural health funding. 2026 is really when we see the socialist model destroying the healthcare infrastructure. So much of healthcare has depended on federal government subsidies which only serves to drive up costs. When vendors know that the customer has really deep pockets, costs of everything goes up, and that's what's been happening. Now more of the country is on poorly-reimbursed Medicaid programs and nurses and hospital staff are more expensive to afford. Rural hospitals are the most vulnerable and are the canary in the coal mine. We need a complete overhaul.

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I saw this report on Fox Business and almost spit my coffee. Apparently Oregon tops the nation in "highest percentage of in-migration" which is 65%. Wow!  The place where people were heading, though, was Eugene-Springfield. Huh? The reasons for in-migration were "tech and healthcare". Well there is no tech sector in that area - certainly not enough to move the needle.  There is healthcare, but only one hospital in Eugene and a few clinics. PeaceHealth is the largest employer there and McKenzie-Willamette Medical Center is in Springfield nearby. Another large employer is University of Oregon, and so maybe it's more educational administrative bloat and union hires. Then there are the school districts - more union hires. It's not really healthy that the biggest employers in the state are hospitals and schools. These don't make money like businesses, and all rely ultimately on government subsidies. Even in Portland, the largest employers have been OHSU and Providence.

Yeah I see that Optum needs physicians in Corvallis and Eugene. 

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5 January 2026

Jaana Dogan, Google Gemini's tech chief, confesses that rival Anthropic's Claude was able to generate code for software that accomplished much of what her team had been working on for over a year.  It's refreshing to read someone's candid assessment of the state of GenAI and implications for the tech sector. It's amazing but also sobering. 

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Polymarket has a new worry. Apparently three possible insider bets predicted Maduro's downfall this past weekend. If the predictions market is open to insiders, what does it mean for the platform? They may have to make some hefty payouts someday. I predict there are going to be some new rules on bets you can place.

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Biotech company, Cidara, thinks they have a universal influenza vaccine, which targets CD388. This certainly beats the WHO's cumbersome existing method of convening representatives from different countries and voting on what antigens to target. Such an unwieldy system.

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Now this is what AI was made for – decoding your cat's meow. We can have stuff like this until model API key subscriptions costs become more expensive. For now, enjoy!

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Not good.  40 million people turn to ChatGPT for health care every day. Not the right tool for that purpose, but for most people it's good enough, I suppose.

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‘Moral injury’ is now officially recognized as mental health condition. Oh well, another excuse to stay home from work. We are such a weak society. It's a good thing WWII happened when it did. If it happened today, we'd lose.

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The Oregonian editorial board wants to make 2026 the year of Oregon's comeback. I chuckled at this statement: "Oregonians should carefully consider candidates’ records and demonstrated competence when they vote." No, Oregonians just look for the "D" and vote for that.

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4 January 2026

The LLM you use to get your news and assess legality can be biased more than you might think. Another reason why one shouldn't make legal decisions just based on what a GenAI model says.

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The memes were right. Here are Democrats in Portland defending the former dictatorship in Venezuela. Looks like No Kings policy is not for Venezuelans. If Trump were to cure cancer, the Democrats would be for it.
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Having had a C-section increases risk of a rare condition called placenta accreta spectrum, where the placenta does not detach from the uterine wall upon delivery. One more thing that obsteticians need to be concerned about.

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Looks like hominids were walking upright as far back as 7 million years ago. This implies that the evolution of modern man took place over a longer period of time. Walking upright frees the hands, and promotes the development of the opposable thumb and the ability to build things.

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CMS is going to propose a new health insurance paradigm for Medicare, promoting preventive measures to improve health. This would be great if it allowed one to save money. They're calling it MAHA ELEVATE.

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Someone created a model called Pocket Brain which allows one to use LLMs even offline without an Internet connection. I don't see how this is different from using a local open source model, likle Ollama which can already do that. I do this all the time. No need to download an app for this.

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Sort of a nice problem to have. Japan has a problem that so much money and real-estate that is held by the elderly with symptoms of cognitive decline, who don't have the resources to manage their money and avoid being scammed. It'll be around $5 trillion USD worth of assets. It's spawning a new industry. One has to be very sensitive about this, of course.

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Could mass just derive from hidden dimensions? Physicists are still pondering stuff like this. Wonder what Sabine Hossenfelder has to say.

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Bluesky is not living up to Lefty hopes. It's full of anti-Trump hatred and identity politics. Anyone would just get sick of it after a while. Just a miasma of hate and nothing constructive to offer.

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