4 December 2025

Collagen supplements can actually make a difference with osteoarthritis, decreasing joint pain. Now a paper showed that the proper ratio of amino acids can lead to life prolongation and better quality of health.  This old ronin could use some of that.

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Does every techie in Seattle hate AI?

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Man cured of HIV after stem cell transplant. It's amazing that HIV patients are even being transplanted at all. Stem cell transplants are a very immunosuppressive process. This could easily have gone the wrong way. And he did not receive stem cells from a CCR5 mutated donor either. Lucky patient. 

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Sam Altman Quietly Tried To Buy A Rocket Startup To Compete With Musk's SpaceX. Somebody stop this guy before he hurts himself.

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After 25 years, the article that Monsanto had been touting saying that glyphosate (Round Up) is safe, is now retracted
The retraction confirms that the “science” used to defend the world’s most widely used herbicide was built on industry manipulation — including ghostwriting, undisclosed payments, and reliance on a narrow selection of unpublished Monsanto studies.
Wow.
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Washington state wants to punish their wealthy with a new payroll excise tax on high-income earners to shore up falling federal subsidies, in order to continue to fund unions and illegals and their own special interests. Time to move out of Washington state, if you haven't already.

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More than 23,000 Canadians died while waiting for health care this past year. "Notably, this number excludes Alberta and parts of Manitoba due to incomplete data. If anything, the real number is likely higher." The socialist model for healthcare never works.

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Great idea. Datacenters generate heat – let's use that.  Datacenters are heat centers.

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Amazon announced the Tritanium4 chip. It's for AI (of course) but the reporter didn't tease out any details about its architecture. I didn't know Amazon was making their own chips, too. Is this going to be a common thing? Then why isn't ASML doing better?

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Ken Ono is a 57 year old established mathematician, but he's going to quit to join an AI startup run by a 24 year old. Brave move. Hope it works out.

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Hundreds of Porsche owners in Russia unable to start cars after system failure in their factory-installed satellite security systems. What kind of cars are being made now? Everything's got to have a satellite link to work? How about just having a car. These satellite links are there so that the company can shut things off when they want. Or track you. They can install all kinds of crap, and you can't do anything about it.

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I didn't know the market for treatment for hereditary angioedema was crowded, but I guess it is. Now there's a new treatment called deucrictibant from Pharvaris.  There's already three approved treatments for this rare disorder. Well, it's nice to have too many treatments than none at all.

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Portland public schools in North Portland gotta consolidate because enrollment is in steep decline. And no one wants to go to those schools. "It won't please everyone" is the understatement of the month.

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Portland’s oldest brewing supply store to close after 108 years. It survived for so long, only to succumb under Democrat Socialist leadership. I know, the clientele is changing, too. Craft brewing was the pride and joy of Portland, but nowadays people want cannabis or fentanyl. Gotta get with the times, you know.

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3 December 2025


And speaking of rear-end, scientists have made it possible to breathe through your intestines: with a single intrarectal dose of non-oxygenated perfluorodecalin. This was the first human trial, and was left in for only 60 minutes. But it's a proof of concept and may be useful in patients with poorly-performing lungs. 

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Sundar Pichai says Google will start building data centers in space, powered by the sun, in 2027. Orbital space is going to get awfully crowded. Hope these satellites can stay out of everyone's way.

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Physicists are devising a system for coordinated time on Mars. Time flows faster on that smaller planet.

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Someone else realizes that healthcare is in a death spiral. The socialist model can't continue indefinitely, and we are now at the breaking point, where Congress is being pressured to fix the problem by renewing subsidies. This is just feeding the beast for another year or so. We can't keep doing this. This is much like the broken immigration system. Everyone felt it was too big to fix, and Trump continues his efforts to deport illegals. It's tough, unpopular work, but it needs to be done. Until then, we'll keep seeing extinction bursts as people complain.

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There's a sword-wielding man hired to kick squatters out of empty Oakland homes. Hire him and he'll move those squatters out with threat of force. Yeah, it's unconventional but times are different now. I think we will need a paramilitary parallel law enforcement arm, because the existing way, under Democrat mayor control, isn't working.

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Gov. Tina Kotek says she’s ready to tackle Oregon’s lousy business reputation. This is a joke, of course, and Oregon Catalyst sees the flaws in her plan. Oregon has depended on federal subsidies for so long, and now all of that is gone. Cost of living has gone up so much locally. Everyone is unhappy with inflation, but it is mainly a Blue state phenomenon

At this website one can see how each state's policies contribute to declining Real Income and CPI.  Oregon is the second worst state in loss of real income and second worst in decline in Personal Consumption Expenditure. The only thing that saved Oregon overall was that it doesn't have a sales tax to abuse. Washington did somewhat better, but was still lousy.  

And Washington wants to institute a new 5% payroll excise tax that will affect the richest companies. The money will go to "higher education, housing, health care and SNAP benefits. Currently the bill does not include a sunset clause."  Unions, homeless and illegals.


Marketwatch says that Americans are unhappy with the economy. It's just people in Blue states.

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So we don't have an AI bubble? Just an air pocket?

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China is taxing condoms to try to get people to have more babies. How about making people feel wealthier?

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2 December 2025

A physician was hired to work at an AI health startup and revealed that they were just a ChatGPT wrapper that was committing HIPAA fraud. They fired him, and now he's suing.

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Earth is spinning faster. Maybe we'll have a negative leap-second.

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Apple names former Microsoft, Google exec to succeed retiring AI chief. They need someone to buff up Siri, for sure. Steve Jobs probably would have fired the guy a lot sooner. Steve never suffered those who made their software the butt of jokes.
Mac software has really been channeling Microsoft of the 2000s. Remember those "I'm a Mac and I'm a PC" commercials? The reason for this is because Windows software was so bad it was a joke. 

And it looks like Intel will get back to making Apple's M-series chips. The stock sure went up. 

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More on Wisconsin's war to ban VPNs. What's wrong with those northern states, anyway?
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Michael and Susan Dell donate $6.25B to fund 'Trump accounts'. Ach, no. This is the wrong approach. Funding Trump accounts only feeds the beast. We need to dismantle the ACA instead and replace it with a better system than the one we have that just puts insurance companies in control and makes them rich. Your hearts are in the right place, Dells, but this is not the way. 

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OpenAI's Altman is begining to panic. Competitors are catching up. And OpenAI is not going to get much sympathy when they try to capture pictures of children in a ChatGPT powered Santa elf toy.

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Legacy nurses and nurse practitioners and physician assistants go on strike. Man, can't the hospitals catch a break here? It's either nurses or teachers in Oregon. The hospitals will cave, of course, what can they do? No one wants to work in Oregon. Then they'll close some care unit or a small auxillary center somewhere. Eventually they'll run out of smaller things to close. Then what? A fire sale to some national chain, is what. And watch what happens to healthcare then.

In other news, Vibra is closing in East Portland.  This is huge, if you're a hospital in Portland, because Vibra took people who were too ill to go home or even to a skilled nursing facility. This will have an impact on discharge planning. 

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So many breweries and public houses in Bend. That's why Bend Police arrest more people for DUI per capita than any other department in Oregon.

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Another one bites the dustNordstrom Rack is closing downtown. Dominoes keep falling.  And get this:
The flagship store remains open but its future has been in doubt since last summer, when Mayor Keith Wilson said CEO Erik Nordstrom had told him, “I don’t know how long we can continue to operate in Portland.”
The Oregonian goes on to say:
Downtown foot traffic has been improving steadily in recent months and Portland officials have been hopeful that the newly renovated Portland Art Museum and the new James Beard Public Market will help bring people back downtown. Thousands packed into Pioneer Courthouse Square last weekend for the annual Christmas tree lighting. 
Yeah, it's not the kind of foot traffic you want. Portland's Christmas Tree lighting ceremony was a Palestinian activism stunt. Who let that happen?

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Portland's new dilemma. Nearly 1,900 affordable Portland apartments sit empty while thousands need homes. They're empty because rent is too high. They can't lower the rent because they need the income because expenses (think employees and debt obligations) still need to be paid. Can't refinance because interests are still too high.  
From the article:
One solution, Salazar said, would be for the state to provide operating subsidies that would allow affordable housing providers to buy down debt at some properties.

With those resources, affordable housing operators like Reach could restructure their properties, she said, but high mortgage payments and other expenses preclude that option today.

“We can’t just drop the rents,” Salazar said.
Yeah, if only they could get more of them "state subsidies". You know, throw more money on the problem. Welcome to reality.
Anyone wanna rent in of these "affordable" apartments?  Don't mind the needles or the trash. Don't leave valuables in your cars. Don't go out after dark. And always pay attention to your surroundings. Why aren't these units renting?

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1 December 2025

Yet another reason I don't believe the climate change hype. The aftermath of the COP30 meeting in Panama is just garbage everywhere.  These climate meetings are just social gatherings for the elite. $2 billion for the elite to spend on themselves.

Yeah, and now we know that environmental activism is linked to dark triad traits and left-wing authoritarianism.

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Linoleic acid in soybean oil contributes to obesity. This is not new since the LA is unconjugated, as opposed to the linoleic acid in meats and dairy products, which may actually counter obesity. This is probably why America got so fat. Well, it helps to know some of the factors, so that they can be countered. 
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Beware of datacenters. Living in proximity to them can be hazardous to your health.

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Economist explains Portland’s decline.  You don't really need an economist to explain it. Everyone knows, except the Democrats in charge.

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Washington Must Break Its Promise on Social Security. Why are we always running out of SS money, but never run out of foreign aid and NGO money? That's what I'd like to know.

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Most corporations don't know how to implement generative AI.  A report from MIT suggests that 90% of initiatives fail.

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Prices must always continue to go up. This is something my younger self never understood. The short answer is that only having prices go down but wages remain the same is not only unfair but destabilizing. Producers would be losing out and leaving money on the table, and that's never going to happen. So everything must get steadily more expensive. This is why I hate unions striking for higher wagers, instead of letting the market determine salaries. Employers are restricted by law from firing striking union members as well as other ways of fighting back. Some have demanded that companies be forbidden to go out of business, and hire striking employees back. Utter crap. So if you don't have a way to increase your pay to stay above inflation, you are screwed.

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90% of Wikipedia articles contain an error.  Higher than I thought, it includes typos, so perhaps this is not surprising.

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Google's NanoBanana Pro steals content. Imagine my surprise.

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Portland mayor declares victory on homeless shelter bed goal. This is meaningless. It's like saying that you're going to attack the cuts-and-scrapes problem by manufacturing 1000 Band-Aids.  You can do it, but it won't solve the underlying problem.  And now, Portland housing authority cuts staff amid budget uncertainty. So who's going to administer and monitor all these shelters.

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30 November 2025

In a proof-of-concept study, medication deiivered by intranasal drops were able to activate the STING pathway in murine glioma tumors. This may be a way to deliver certain treatments directly to intracerebral tumors.

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Only a third of Americans now see college as being worth the cost.  I fully agree. Most people haven't saved enough for college. Why go into incredible debt at usury terms, just to be woke-indoctrinated and come out with knowledge that still isn't enough to secure you a good job. Who woulda thought this a few years ago? 

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Handwriting recognition has gotten really good lately, especially with Google's latest Gemini model (the Pro 3).

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The automated glassbreaker you have in your car is now ineffective against the newest laminated glass.  There's still no tool out there that will break laminated glass. This is an unmet need.

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Startups are finding out that anyone can use AI to copy their idea. That's what happens with low barrier to entry apps.

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A group of metabolites, known as indole compounds, has anti-aging, anti-inflammatory and antimicrobial properties, and a bacteria is capable of producing them. The bacteria is  Paracoccus sanguinis.  Is this true? Why haven't I heard of this before?

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A reminder that the illusion of consensus is powerful. Just because most people think something is true or the right decision doesn't mean that it is. Think of COVID-19 policy. Not only might it be wrong, but it may be an instantiation of the Abilene paradox. Don't be fooled.

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Most children identified as gifted at age 7 do not maintain high cognitive ability by adolescence
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Nursing Is No Longer Counted as a ‘Professional Degree’ by Trump Admin. I'm not sure how this will really affect the number of nurses that we will have. Nursing has changed a lot over the years, and nurse practitioners function similarly to doctors. But one thing that distinguishes nurses and nurse practitioners from doctors is that they unionize and strike. Real professionals, like doctors and lawyers don't strike and abandon their clients. This is something that the labor class does. By unionizing and striking, nurses debase their profession, and put themselves in the same group as those who are plug-and-play replaceable.

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A primary motivation for the trial was the high content of L-arginine found in peanuts. L-arginine is an amino acid that serves as a precursor for the synthesis of nitric oxide, a molecule essential for relaxing blood vessels and regulating blood flow.

Additionally, the study focused on skin-roasted peanuts because the peanut skin is rich in bioactive compounds, including polyphenols like resveratrol, which have antioxidant properties that may further support vascular health.
Arginine again. Not sure if resveratrol does much. Studies of this drug haven't held up.

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Oregon's median income has increased, but growth of the economy has lagged behind. Seems counter-intuitive, but the answer is that income has increased because of strikes and union-demanded pay increases. This actually hurts business and keeps the labor market soft. Not that anyone cares in this state.  Gas prices around here remain high, and will increase if the Transportation Bill stays into law. But in other parts of the country, the price of gas has decreased below $2 /gal.  And people are starting to take notice.

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Sick. The Oregon Health Authority, state of Oregon, are sending out questionnaires to sixth graders asking them their sexual identities and sexual orientation. This is depraved. What sicko decided this was appropriate. And why aren't parents protesting?

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And Portlanders wonder why apartment construction has come to a halt in the city.  It isn't just the Urban Growth Boundary anymore. Think about it. Who would care to spend the money to build new apartments in the city limits? Only a fool, that's who.

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29 November 2025

If you buy a 3D printer from Flashforge and print a gun, they will apparently cancel your account and will notify "authorites". I can't see anything on their website that says this as of today, and all mention has been only on social media, so who knows if this is true.

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Who knew? You learn about subjects better if you do the search yourself, rather than have a chat model provide you with the summary. 
participants reported developing shallower knowledge from LLM summaries even when the results were augmented by real-time web links
And maybe sometimes what the LLM produces is not factually correct. I've seen that happen before.

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Recent epidemiological and clinical evidence is systematically summarized, linking coffee consumption to reduced risks of chronic liver disease, hepatocellular carcinoma, nonalcoholic fatty liver disease, and chronic kidney disease
Could it really be that easy?

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redistribution and polarization are the lowest in networks with maximum assortativity, where participants are segregated by wealth, and the highest in networks where the rich are most visible. Furthermore, segregation keeps the poor poorest but satisfied, while observing the rich makes them dissatisfied despite becoming better off. These findings suggest that political communication and policy strategies aiming to increase support for redistribution should enhance the visibility of excessive wealth. 
This is why wealthy people would rather live amongst others of their socioeconomic class. Because who wants to live around people that hate you. I've never understood why lefties always demand mixed housing, like Portland does, where a portion of the apartments built need to be for low-income tenants. How does that help? The wealthy are never going to demand to keep poor people away because that would sound heartless. But this study shows why this makes sense.

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There's a newly-recognized form of dementia, called LATE-NC, which stands for Limbic predominant age-related TDP-43 encephalopathy neuropathologic change. It's not rare and it can accompany Alzheimer's disease, making it even worse. In this condition, one finds TDP‐43 proteinopathy instead of amyloid plaques. There's a clinical trial with a drug called nicorandil.

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James Garfield was smarter than your average president.  He even got published in a math journal.

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The Supreme Court Is About to Hear a Case That Could Rewrite Internet Access. May saner heads prevail.

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28 November 2025

The Impossible Prompt That's Easy for Humans. This is Moravec's Paradox. Stuff that is easy for a child is too difficult for advanced GenAI. Here's proof.

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Tattoo Ink Moves Through the Body, Killing Immune Cells and Weakening Vaccine Response. Do you know what's even in tattoo ink? Carbon black, polycyclic aromatic hydrocarbons and azo dyes.  
Tattooed participants had higher risks of skin cancers — including melanoma and squamous cell carcinoma — as well as lymphoma, with hazards rising further for tattoos larger than a palm. In one arm of the study, large tattoos were linked to a 2.7-fold higher hazard of lymphoma and more than double the risk of skin cancer.
What's the attraction with tattoos? You'll look like a funny old person, that's for sure.

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Inhibiting a master regulator of aging regenerates joint cartilage in mice. Apparently, blocking the function of 15-PGDH with a small molecule results in an increase in old animals' muscle mass and endurance.  15-PGDH is a gerozyme due to its increase in prevalence as the body ages, and is a master regulator of aging.

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I had been thinking about getting an Oura Ring, especially as it's being sold at Costco. But now, I think not
For the past couple of weeks, there has been an ongoing uproar from Oura customers following the announcement of a partnership between the wearable smart ring maker, and the U.S. Department of War and Palantir. 
...a spokesperson for Oura tells me that the company has received government demands for customers' data.
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Utility rates up 50% in Oregon. Here’s why.  Short answer: datacenters, taxes, and ill-advised investments in renewable energy. Germany is also learning the same painful lesson.

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An important component of this highway is a region in the center of the brain called the thalamus, which not only helps select which memories should be remembered, but routes them to cortex for long-term stabilization.

The model suggests that, after the basic memory is formed in the hippocampus, Camta1 and its targets ensure the initial persistence of the memory. With time, Tcf4 and its targets are activated providing cell adhesion and structural support to further maintain the memory. Finally, Ash1l recruits chromatin remodeling programs that make the memory more persistent.

“Unless you promote memories onto these timers, we believe you’re primed to forget it quickly,” Rajasethupathy says.

The results suggest that long-term memory is not maintained by a single molecular on-and-off switch, but by a cascade of gene-regulating programs that unfold over time and across brain regions like a series of molecular timers.
Interesting that the thalamus is involved. It's central in so many things.

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This is why Portland is a ghost town.
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Dan & Louis Oyster Bar.  Started in 1907. Survived two World Wars. Survived the BLM riots. Survived COVID-19. But now closing because business is too slow.  Good job, Dennis Wilson. Keep littering the city with homeless shelters. We need more because other states are sending their refuse our way. Yup, 75% are imported.  Come to Portland and get a free house. And shoot up all you want.

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Oregon topped the nation in Thanksgiving family arguments.  The state is always #1 for the wrong things, you notice?

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27 November 2025

The NEJM put out a study last week, which makes it appear that the Pfizer mRNA influenza vaccine is really superior to the standard licensed vaccine. The trouble is, it's only superior in those younger than age 64. In the older population, which is those more likely to suffer the consequences of having influenza, it was no better. The NEJM editors should have caught that, but they didn't. And even regular influenza vaccine doesn't always help. Last year's version actually increased your chances of getting the flu.

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MIT study finds AI can already replace 11.7% of U.S. workforce. I always take these studies with a grain of salt because it's really hard to gauge this, and things change constantly.  But it doesn't bode well for people in the short term. Better develop new skills. 

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Do you want a foldable iPhone? Not really. I'm happy with what I have. The price point is too high. And I just know it's going to break.

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So Dennis Wilson is going to reach his goal of spewing 1500 shelter beds around the city.  Big deal. There will still be plenty of drug-abusing homeless on the streets. What a grand waste of money. Not solving the problem, Dennis.

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26 November 2025

Amazon Leo UItra is the new rival to Starlink.  It'll be faster, too, capable of 1 GBps instead of the max 380 MBps with Starlink. It'sll probably cost more, though. Doesn't start until sometime in 2026. What will Elon do in response?

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Netgear is also rolling out a new Nighthawk MiFi modem that reached 3.6 Gbps. I'm not sure if my wireless carrier will support this. Looks like you gotta sign up with Airalo. That's too bad.

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First, a former physician used his personal email address in a meeting group, contrary to hospital policy. Second, the meeting organizer did not remove the physician from the meeting invite following his departure in June 2023, according to the Information and Privacy Commissioner of Ontario.
As a result, when the physician installed Otter.ai on a personal device in September 2024, the transcription tool was able to access the rounds meeting invite via the physician's personal digital calendar.
...it wasn't clear whether the physician even realized the Otter.ai bot had attended the meeting on his behalf and recorded it – or whether it had done so for other meetings as well.
“That’s a whole level of autonomy and independence that we haven’t been prepared for but need to start thinking about,”
This is a new vulnerability. It's not going to be just healthcare, but every virtual meeting where confidential matters are discussed.

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I just thought this was a sneaky way for a Chinese app to get all sorts of personal information from you. Well, at least the developer tells you:
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Beware of AI slop Thanksgiving recipes.

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GPT-5 is the best predictor of the future.

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Elon Musk Drove ~1/3 of Women Off Twitter. Well, I think X is much better now. It's more balanced now that conservative voices have a say and are not automatically censored, like back in the Trump 1.0 days.
Check out the New Must-Have College Admissions Skill: Tolerating Other Viewpoints.  

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Data center provider razes 55 homes to make room for Illinois campus. Sign of the times. And then, there is Oregon. "‘The precedent is Flint’: How Oregon’s data center boom is supercharging a water crisis."
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Daily coffee drinking may slow biological aging of people with major mental illness. But why just those with mental illness? Drinking up to 5 cups lengthens telomeres, and gives you "the equivalent of 5 extra biological years". I'll take it.

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Brain changes observed during pregnancy. Yup, I've noticed it.

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The gruesome new data on tech jobs. I remember during the dotcom era, techies were SO desirable. They were millionaries. Now, they are struggling to find a job and a sense of self-worth, with feelings of doubt and perhaps betrayal.

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Southern Oregon is the canary in the coal mine. Actually many of the coastal towns in Oregon are. Sucks to be in a Blue state, when the rest of the country is doing fairly well, or at least is not hurting. Oregon had seemed like it was doing OK, but it was all due to federal subsidies. Paying for this and that. Plus illegal immigrant labor. Now that's all gone, and Oregon is suffering. It's painful, but a cleansing is overdue.

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25 November 2025

Americans are holding onto devices longer than ever and it’s costing the economy. Costing the economy? You gotta be kidding. One reason not to buy a new phone is the hassle of transferring everything over. Sure Apple has made it easier, but you often have to re-login and enter credentials for apps again. And newer phone aren't that revolutionary in what they offer. I've haven't noticed my photos being that much different.  Offer Tony Stark's phone and I might consider it.

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Quick – what's the largest city in the world?  Tokyo, you say? Nope. It's Djakarta.  What's #2? Dhaka, Bangladesh. In third place is Tokyo. Then New Delhi, Shanghai, Guangzhou, Cairo, Manila, Kolkata, and Seoul. What does this tell you about the future of the world?

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Tina Kotek is now worried about the price of gas because of what the Olympic Pipeline leak might do, in terms of a shortage. Maybe you could halt the gas tax, Tina? Afraid that people will revolt at paying $5 per gallon for regular?

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Cheetos and Doritos will be sold without artificial dyes and without the powder that we've all come to expect. Doritos will look like regular tortilla chips. Still won't be considered "healthy" for you. 

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Is kimchi good for your immune system? This paper suggests that it might be. I think if you can eat it and survive, your body must be especially tough.

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Another paper says that there are changes in your body at certain ages. This paper is focused on the brain, and says that ages 9, 32, 66 and 83 demarcate distinct cognitive eras. You know, I have noticed changes since being an older ronin. I'm less tolerant of B.S. now and less anxious about things. I don't worry as much about the future. I think hormonal changes in puberty certainly have an effect and would mark a change at age 14 for boys and age 12 for girls. Certainly at menopause, women think differently. At age 83, your brain is showing the effects of all sorts of things: alcohol, chronic stress, head injury, your education, how much you cultivated learning things and maintaining interest, and overall physical activity.

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Gallup ranked states in terms of how excellent they are in healthcare, and what surprised me is how uniformly lousy they all are. There's not much difference in quality of healthcare among all the states – they're all about the same. This actually makes me doubt the quality of the ranking methodology. Healthcare in certain states (like Texas, Massachusetts, New York and California) definitely have access to quality care. They suffer from other things, but quality in a few states are definitely better than others. Oregon is near the bottom (as usual) and even with OHSU, the state got a C grade.

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So funny. Katie Wilson is now thinking she would meet with Trump if he asked her. No, Katie. Trump met with Mamdani because he asked for the meeting and Trump has interests in NYC.  He has no interest in Seattle. You're on your own.

And Seattle is ending their program supplying crack pipes and tin foil to the homeless drug users. I bet Katie Wilson will restore it, though. 

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Phil Knight gave $3 million to help elect Republicans to Oregon government.  As long as we have mail-in balloting and ballot counting over several days after election day until the preferred candidate wins, that will never happen. Don't throw good money after bad, Phil. Oh well, it's not my money.

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"After an extensive national search" OHSU Health hired a CEO. It's always an outsider – no one internal either wants the job or has enough support from colleagues. This guy came from a Kaiser hospital in the Bay Area. Kaiser isn't known for excellence in medical research, but perhaps he'll know how to save money for the hospital.

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