21 October 2025

California Keeps Losing Tech Jobs. I suspect the movie business is dwindling, too. If tech really moves out of the Bay Area, to places like Texas, Boston, Puget Sound, or North Carolina, the California will hurt for sure.

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Earth gained a pseudo-moon, which is predicted to hang around until 2083.  It's "probably been tagging along for around 60 years" but was just found. Too bad it won't be another visual object in the sky, but if it did, it would probably cause all kinds of gravitational havoc.

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The new iPhone's keyboard is deliberately causing typing errors. Apple needs to fix this. I never liked that users were locked into using the default keyboard.

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As eyes get older, the activity of the ELOVL2 gene weakens. This gene helps produce both very-long-chain polyunsaturated fatty acids (VLC-PUFAs) and DHA in the retina. Injection of mice with these VLC-PUFAs enhanced their vision.  Paper here.

Elon Musk threatens to leave Tesla if he doesn't get the enormous pay he demands.  He wants up to $40 billion in compensation. That's ridiculous for a company like Tesla, in a world where EV allure is declining.

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Has Amazon lost too many engineers?  The way the recent AWS outage unfolded suggests so. The whole AWS system is so complicated and opaquely documented that this doesn't surprise me. I was never certain I was using SageMaker properly. You have to make sure you cross off many things on a checklist before you close out, or you could be running up a huge tab with a hidden endpoint left running on. There are so many names for so many services they offer and you can't tell immediately what does what, and whether it's something worth diving into. 

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The world has become much more reliant on fossil carbon (even as its relative share has declined a bit). 

During the 1970s many people believed that by the year 2000 all electricity would come not just from fission, but from fast breeder reactors, and soon afterwards came the promises of “soft energy” taking over (Smil, 2000).

“Even if we were to replace just 60 percent of today’s fossil fuel consumption, we should be investing about six times more, or about $13 trillion a year, to reach zero carbon by 2050. Making it $15-17 trillion a year (to account for expected cost over-runs) seems hardly excessive, and it takes us, once again, to a grand total of $400-460 trillion by the year 2050, good confirmation of a previously derived value.
We're not ready yet to replace petroleum-based fuels. Vaçlav should stop calling it "fossil fuel" because it's not really that anymore.

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Photodynamic therapy is still alive, but this time with LEDs instead of lasers. It works against skin cancers. Since LEDs are easier to work with than lasers, perhaps this might be something that could work with immunotherapy.

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This headline "Student Loan Forgiveness Update: Trump Admin Cancels Debt For Millions" made me think Trump was pulling a Biden on student loans. In actuality, he's just reversing a decision made earlier this year in February to start enrolling and processing income-driven repayment plans. It shouldn't have been stopped, and now it's restarting. This is different from what Biden tried to do.

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OpenAI's agents are now going to recommend people do some shopping. Sounds like I better get some stock in Shopify.

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The graying of hair in the elderly may be a manifestation of a natural process that melanocytes undergo to prevent melanoma genesis.  I never looked at it that way, but perhaps we were meant to go gray.

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Oregon tops the nation in prevalence of mental illness of all kinds. 30% of Oregonians are mentally ill in some way. Washington's prevalence is 28%.  But it's way too high in all the states. Even in the lowest state, it's around 19%. 
Oregon is #4 for substance abuse. District of Columbia is #1 for substance abuse, and it's scary that those people make the laws. No wonder the politicians are crazy.  Utah leads in suicidal thoughts but Oregon is #3.

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20 October 2025

OpenAI's ChatGPT is so popular that almost no one will pay for it.  If they charged a small fee at the beginning, people would be fine with it. And it would have helped moderate use. But it's probably too late to demand a fee now. People will protest loudly. And OpenAI is losing a lot of money.  

OpenAI is losing about three times more money than it's earning, and 95 percent of those using ChatGPT, which generates roughly 70 percent of the company's recurring revenue, aren't paying a dime to help stem the losses.

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Combination of immunotherapy and targeted therapy boosts colorectal cancer survival.  This is the phase 3 STELLAR-303 trial for those patients (a majority) with no special markers, like dMMR, BRAF or HER2 mutations.  It was a combination of a multi-TKI and an immune checkpoint inhibitor (zanzalintinib plus atezolizumab) against regorafenib, which is the standard, and difficult to tolerate. This may be the new standard.

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What? Cancer patients who got a COVID vaccine lived much longer. Maybe the autoimmune effect worked to their benefit. This was just presented at a conference, and the paper hasn't been published yet, so I'll wait and see the data. Counterintuitive, if true. 

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Braaiiins...  Stanford scientists grow thousands of mini human brains using common food additive. That food additive is xanthum gum. I'm not sure a clump of neurons qualifies as a mini-brain. There needs to be more to it than that.

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What’s behind demand for more housing?  In Oregon, particularly? Are people really moving into the state and not finding enough housing? Who are these people? Are they the homeless? The illegal migrants? Vagrants ready to enjoy the relaxed laws and generous social benefits? That's the question I want answers to.

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Portland asks voters to stomach big property tax increase or watch parks deteriorate. I'm not convinced. As it says at the end of the article: “Portland doesn’t lack revenue. It lacks discipline and a plan."  Fully agree.

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Holy Frankenstein. Looks like Trantifa is going to have a seminar on how to make your own hormone replacement. Just in time for Halloween.

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Shades of Ted Wheeler.  Portland Mayor: ICE Facility Is a Disaster Waiting To Happen. Portland is already a disaster, whatcha talking about?

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19 October 2025

Testosterone makes Democrats turn more conservative.  This actually came out in July, and is worth repeating in light of the recent socialist rallies that blend pro-illegal immigration with Antifa and BLM and Palestine supporters and transweirdos. Essentially everything that is against what Trump stands for.  And we know that mean testosterone levels have greatly decreased over the years, especially during the Obama years. Even OHSU scientists hit upon the reason why. 

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Podcast Magic app looks magical indeed, if it works. I haven't tried it. But yeah, if you wanted to dive deeper into something you heard, this could be a way to do it.

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Facebook’s new button lets its AI look at photos you haven’t uploaded yet. I know they need more data to feed on, but this is crazy. What an invasion of privacy. Why anyone wants to put the Facebook app on their phone is beyond me. More and more, Facebook crosses lines of privacy, and people seem to just shrug.

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Matt Ridley, former science editor at The Economist, is not at all concerned about a "climate crisis". Is this why Greta Thundberg has also moved on to other things? (/jk)

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We little people are already concerned with how much AI costs to do our little projects. 

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Awesome ChatGPT prompts. Is that really all it is?  This is for beginners. 

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Can't blame him. Portland Art Museum Director Brian Ferriso Is Leaving After Nearly 20 Years. Like rats deserting a sinking ship. Better leave for some other city where there is some future in an art museum. In Portland, art is probably something for activists to destroy to get attention. And few dare to go downtown anymore, lest you be in the wrong place at the wrong time.

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18 October 2025

The Pope wants to set rules on AI now. He wants "global AI regulation and fair distribution of the technology's benefits." I want world peace and for people to behave themselves so we all can have nice things.

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I came across this substack, called The Old Grey Thinker, and I think he's on to something. There's a wealth of gray hairs that still have much to offer, and have old school values and work ethic that makes them far more valuable than your usual millennial. Society is not taking advantage of a valuable resource. In other posts, he describes what can be done to make use of one's energy and cognitive skills, but I still think it's not enough. Retirement is just a pivot, not a relegation to vegetate. This ronin is keeping busy making use of this second life.

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Use of GLP-1 receptor agonists may affect the reading of PET/CT scans, due to their effect on glucose metabolism. One might have to stop taking them a month before a PET/CT scan for the effect to wear off. That's not practical, though. It's kind of like taking metformin – that really affects PET/CT scans.

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Usage of ChatGPT is declining. People are seeing its limitations, and it's not so novel anymore. And it can get people into trouble anyway.

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More lithium battery tech improvements, this time from South Korea. Using a thin coating of silver can prevent formation of dendrites, which can cause overheating or shorting.

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Neuro-inspired AI can give robots a sense of fear, which can instill a sense of self-preservation. Do we want this, though? What's wrong with robots who don't sense fear? Could be a good thing, actually.

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Comet Lemmon borders on naked eye visibilit now. Still a bit difficult to see, especially for the Pacific Northwest.

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Trump is going to make the citizenship test harder. No more easy questions, like "what is the ocean off the west coast?". Candidates must also have good moral character. That will eliminate more than a few. This is why we can't have illegals sneak in.

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Of course. Dogs do better with real meat in their diet, not kibbles.

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AI in Healthcare: Redefining Liability for Doctors and Hospitals. This is a UK-based discussion, but much of it is still relevant to the U.S.

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Samsung is stopping production of their super thin phones because no one wants them.  Just like no one wants the iPhone Air – way too thin and bendable.  Stop this trend, already. People want solid and durable phones that perform well. 

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17 October 2025

A new "Superwood" is as strong as steel and 6 times lighter. Funny that they mention that we could have wooden cars in the future. Those old stationwagons were ahead of their time!

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Scientists think that the defect in Hutchinson-Gilford progeria syndrome (HGPS) may be with lysosomes that fail to clear progerin, leading to its accumulaton. Modifying these defecting lysosomes might be a way to treat this condition.

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Amazon's Ring network will pair with Flock AI cameras, used by ICE, feds and police. Another tool to get illegal aliens.

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China enters into the uncanny valley with humanoid robots. No thanks.

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How close are we to conscious AI? I'm also reading Dan Brown's new novel Secret of Secrets, coincidentally.


And someone posed the eternal question about how to create a searchable knowledge base.  Doctors have been wanting this for a long time. It's interesting to see all the "solutions" proferred. Someone mentions Zettelkasten – yuck, what a labor-intensive tarpit that is. Use it if you love index cards.  

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California can't be trusted with federal money. What a grift.

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Finally. Toyota is going to use some of the new lithium battery technology I've been reading about. Solid state lithium batteries. But not until 2027.

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GPT-5 is less safe than GPT-4o. This report says that the safeguards are weaker. Boy it's hard to deal with all the crazy ways people use LLMs. Perhaps use should be restricted. I think it was crazy to give the general public easy access.

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VDPHL01, is a re-engineered extended-release version of oral minoxidil and is close to being approved as a pill to halt hair loss. Works for both men and women.

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Nostalgia for the old AltaVista search engine days. We used to think this was cutting edge.

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Legacy Health is closing three urgent care clinics now, as well as the Devers Eye Institute and outpatient rehab centers. All because of finances. And despite this, the nurse practitioners want to strike.  Legacy gave the impression it was financially stable when the OHSU merger fell through, but I guess they are still unstable.

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16 October 2025

Nice news. Scientists extend lifespan by over 70% in elderly male mice with Alk5 inhibitor (OT+A5i), which can greatly improve both lifespan and healthspan in older, frail male mice.  Interestingly, "female mice did not experience significant gains in lifespan or healthspan, though middle-aged females did show improved fertility after treatment". Oh well. 

And then comes this study: Humans peak in midlife: A combined cognitive and personality trait perspective. Yeah, peak human comes at between the ages of 55 and 60 years. Personality is more stable. I am getting less extroverted, that's for sure. And more conscientious and emotionally stable, and less agreeable. All true. 😄

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Plug-in hybrids pollute almost as much as gas-powered cars. But that's not the reason many people buy them. They buy them because gasoline is so expensive. Much more so that electricity as off-peak hours. I don't care about CO2 emissions, really.

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I read this article about how CDC workers are "tormented" due to the government shutdown.  A terminated scientist who spoke on condition of anonymity said that her entire office was eliminated in the RIF (reduction in force). "Ultimately I am terrified for the public safety of our country." I gotta chuckle about that, given how evil the CDC was during the COVID-19 era.

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Head of Apple's AI Search Project Leaves to Join Meta. It seems that the techies have little confidence in Apple getting their AI stuff together. But I don't see Meta as coming out with anything great in the AI field either. What are they doing with all that brain power that they've swiped away? The real leaders are at OpenAI, Google and Anthropic.

But good news for Apple – Steve Jobs is going to be on a dollar coin next year. Who will Oregon select when it's the state's turn in 2027?  

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About half of the article on the Internet are now authored by AI. They counted articles that just had some AI contribution.

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And...Legacy nurse practitioners, physician associates and clinical nurse specialists voted to strike. I remember when hospital systems started hiring them in order to save money on doctors. They should have paid for doctors instead, but the last group that wants to strike or play hard line to get raises are the doctors, pushovers that they are. They would never dream of jeopardizing patient care for political reasons, right? These advanced practice providers know that when they aren't working, doctors will step in and pick up the slack. Doctors can't do that, so they don't strike. It's against their principles and work ethic. Ah, how the medical scene has changed since Obamacare.


Know any doctors? Here's a healthcare plan:

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Names seem to change facial appearance. It seems that the name you are given as a child does affect your appearance. Paper here.  And some people with variant faces, can't pass through facial recognitiion systems. Clearly, there needs to be additional machine learning training instead of subjecting these people to more grief and humiliation.

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“It’s lower than what we hoped."
Yeah, no kidding.

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Crystal Mountain announces $1,499 pass for express lift lines. And there's Ron Wyden, decrying inequality. How unfair. 
Yeah, he wants equal outcomes, not just equal opportunity. If the bottom quintile can't afford it, it shouldn't be made available for anyone, right Ron?  We can't have nice things in Democrat land.

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This is typical Portland. Speed cameras funnel overtime $$ to budgets.  Portland voted to allow non-police to take over the workload of speed cameras violations, because they were falling behind. But this easy job generated a lot of overtime pay for the police, so they aren't ready to give it up. Approving speed camera tickets for overtime pay sure beats battling protestors at the ICE headquarters, right?

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Portland parks’ future imperiled by poor financial management, city watchdog warns. No more nice parks for you, Portland. But keep paying your taxes, fools. And keep voting Democrat.
Yeah, Portland's got the highest taxes in the nation, all right. Higher than NYC, San Francisco and Newark. Just imagine if we had a sales tax on top of it all. And Portlanders get so little for all that tax money. 

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And the kids are depressed, too.

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Where are the world's millionaries going? And where are they fleeing?

This tells me that a lot of the world's millionaires are Asian. Why else you would you flee to Japan, China, South Korea or Taiwan?

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15 October 2025

Well, this video might convince me to get the iPhone 17 after all.  There's no music released yet to take advantage of this yet, however, so no rush. Why haven't I heard of SPR-AVS and ASAF outside of this video?

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A detailed look at how modern browsers work, in case you were ever interested.

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The Japanese government wants people to stop using manga and anime art to train AI.  Yeah, good luck with that. Toothpaste is already out of the tube.

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Looks like transgenderism is on the decline amongst American students. Thank goodness. Probably because the weirdos took over the image and made it look just mentally ill instead of something cool. Paper here.

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New Alzheimer's Treatment Clears Plaques From Brains of Mice Within Hours.  This is remarkable. They used nanoparticle delivered drugs and ultrasound to relax the blood-brain barrier. Worked like a charm. Now to see if humans can be helped.

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Top US Army General Says He’s Letting ChatGPT Make Military Decisions. Uh no. I don't think this is proper. We shouldn't be waging war like this.

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Humans on bikes are very energy-efficient it turns out.

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Here's an argument for why AI is not in a bubble.  Dang, you need a subscription to learn why. And I dunno, just a couple of weeks earlier, Derek wrote about how the AI bubble will pop. This all sounds like clickbait, doesn't it? 

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Get a load of this. The Reynolds district is running out of money. So they have to shorten the school year because the teachers got an expensive raise. But this will put their school year below Oregon's school year length requirement. So what will they do? Why apply for a waiver with the state, of course. Because f*ck the kids, that's why.

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Portland Dems and Antifa supporters like to say that Portland is entirely normal, and there's no need for any law enforcement. Take a look at Kevin Dahlgren's snapshot of downtown Portland. The Dems want you to be conditioned to think this is perfectly normal. 
This is the frog in the boiling pot. If you see this enough, you get numbed. Happens all the time. Nothing to worry about. Keep electing Dems.

And Seattle's response to all the prostitutes on Aurora Avenue is to issue a stern letter. Yeah, that'll take care of the problem. 

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And this is why they need all that tax money – to pay for illegal aliens healthcare.  This underlies the Schumer Shutdown. 

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14 October 2025

Alzheimer's disease may not be a brain disorder after all? This theory says that beta-amyloid is a normal component of the brain, and is part of the immune response.

In our model of Alzheimer's, beta-amyloid helps to protect and bolster our immune system, but unfortunately, it also plays a central role in the autoimmune process that, we believe, may lead to the development of Alzheimer's.

When brain trauma occurs or when bacteria are present in the brain, beta-amyloid is a key contributor to the brain's comprehensive immune response. And this is where the problem begins.

Because of striking similarities between the fat molecules that make up both the membranes of bacteria and the membranes of brain cells, beta-amyloid cannot tell the difference between invading bacteria and host brain cells, and mistakenly attacks the very brain cells it is supposed to be protecting.

So attacking beta-amyloid with monoclonal antibodies may be the wrong approach.

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Influencers are out of a job. Now companies can create AI influencers and post them to TikTok. And they won't ask for free stuff or cause problems like real influencers.

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Wow, ProtonVPN does log user data after all.  They say they respect privacy and don't keep logs, but "ProtonVPN can inspect your traffic and tie it back to your account." Not good. NordVPN gets my money now.

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Comparison between Tim Cook and Steve Jobs.  Tim Cook definitely kept the plates spinning, but innovation-wise, it hasn't been the same.

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New California law requires AI to tell you it’s AI.  Leave it to California to pass the dumbest laws. The lawmakers there are just schoolchildren in adult bodies. 

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Here's a theory that purports to explain why you can be so confidently wrong about something. Why you might have poor judgment about reality. Information that seems to be easily absorbed and processed could be wrong. Kind of like TikTok News.

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What causes chemo brain? Researchers at Fralin Biomedical Research Institute and Virginia Tech's Department of Biomedical Engineering and Mechanics have found chemo-induced abnormalities in the glymphatic system.

The study examined effects of two of the most common chemotherapy drugs, docetaxel and carboplatin. While both showed lymphatic system impacts, they were much more pronounced with docetaxel.

"What we see is a shrinking of the lymphatic vessels, and fewer loops or branches in the vessels," said Munson, who is also a professor in Virginia Tech's Department of Biomedical Engineering and Mechanics. "These are signs of reduced growth that indicate the lymphatics are changing, or not regenerating in beneficial ways. Lymphatic health really declined across all three models measured in different ways."

Hope these alterations improve. Not everyone gets them. Perhaps this is why exercise seems to cause improvement because it does get the glymphatic system more active.  Paper here.

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What makes a startup company more likely to succeed? Perhaps if it is a "fuck you company". Think about it. We love to do something when we think we're sending a "fuck you" message to some large dominant corporation.  Here we are, sticking it to the man, right? Otherwise, nobody cares about your little startup that just solves a problem nobody has, or is just a little better but requires some effort to change your routine. Nobody cares about a better YouTube or a better Facebook. But what if you could say Fuck You to the tax industry? Hotel industry? Brokerage industry? Don't just be better. Be different.

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The Nobel Prize in Literature Is Boring Now. Yeah, who really cares? I generally don't read that boring stuff.

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In Seattle, all those new taxes are causing small businesses to close. And they think it makes Portland more competitive now. Funny.

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There's a YT video about the vast network of license plate readers across the country.  Yeah, it's an invasion of privacy, but it's the consequence of having so many criminal elements running around. But the thing that seems to get the person who made the video is that it's helping ICE catch illegal aliens. Really?  That's what you're upset about?  

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This is why you have to read conservative media. You miss out on a lot of things.  Some major news.

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West Linn is the safest city in Oregon.  Coos Bay is the most dangerous. In Washington, Sammamish was the safest and Tukwila was the most dangerous, no surprises here. 
In the nation, the safest states are Red states, and the most crime ridden are Blue states. This is why much of Oregon wants to become part of Idaho. 

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TriMet plans service reductions starting next month, 'deeper cuts' in 2026.  Just as well. Public transportation in Portland is just crime on wheels. Thanks to TriMet, "Portland's Best" can spread their urban goodness to neighboring cities. 

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13 October 2025

Poor Tommy Flowers never got the recognition he deserved designing the first electronic computer.

The world’s first digital electronic computer, forerunner of the ones reshaping our world today, was built in Britain to revolutionise codebreaking during the second world war – a mind-boggling feat of creative innovation – but Turing wasn’t in the country at the time. Neither was it conceived by the mostly private school and Oxbridge-educated boffins at Bletchley Park. Rather, the machine Park staff called Colossus was the brainchild of a degreeless Post Office engineer named Tommy Flowers, a cockney bricklayer’s son who for decades was prevented by the Official Secrets Act from acknowledging his achievement.

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The Myth of Falling Crime: Why Americans Don’t Trust the Numbers.  Yup, the official crime statistics are fake and no one believes them.  And here's Ranked: Europe’s Most Dangerous Cities, According to Citizens.

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It may be time for the U.S. to copy China this time. China builds new self-healing battery for EVs and phones with triple lifespan.
And China is going big on robots, have you heard? They're not the robot arms that we're used to seeing here, but humanoid robots. 

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Bride surprises new husband with an RTX 5090 on wedding day.  Forget love and romance. It's time to install this baby and run some inference on machine learning models. Maybe mine some coin. Amirite?

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Forget M4. Apple will be ready to release M5 Macbook Pros.  The commenters are unimpressed. Yeah, it's been tough to notice significant improvements with each release. More incremental than impressive. Apple does seem to have run out of new ideas. I'll still give this a sugoi though. 

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You can hide malware in DNS records now. How widespread is this?

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In computer science, in the section on networks, you've probably heard about Dijkstra's Algorithm, computing the shortest distance between two points. Well, some scientists found a faster way of calculating this. This is important for things like stereotactic radiosurgery, where a thin beam of radiation blasts a tumor in different directions, and the intersection of all these beams is where the radiation intensity is the highest. Picture a head with dots on it, marking where the beam will be directed – that's the network. You want to calculate the quickest path that will direct the beam from all different directions, and this calculation will do that.

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Canadians were shunning Oregon this summer.  Certainly understandable. The state has gotten less attractive. And I'm not even talking about the recent naked bike ride. Ewww.

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As they say in medicine: Great case! A great clinician deduces the cause of a medical mystery, without using AI. Actually it would be interesting to see if AI could deduce the cause of this man's symptoms.

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Disgusting. Oregon Now Spends More On Program Offering Free Health Care For Illegal Immigrants Than State Police. It's for this that the government is currently shut down. Enough already. 

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12 October 2025

Botrank.io is the first and so far only ranking site for consumer robots.

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K102 and K110 are compounds that purportedly help regenerate the damaged myelin sheath in patients with multiple sclerosis. They are two chloroindazole-based estrogen receptor-β-selective ligands. Paper here.

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Someone else doesn't want to use Microsoft's OneDrive for hard disk backup. Why is Microsoft doing this all of a sudden? It's like Apple forcing people to use iCloud, which I also dislike.

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I've wondered about this. It was accepted as perfectly fine and normal for women athletes to being amenorrheic. But it was actually making them develop osteoporosis, and who knows what else, since it's believed to be caused by  increased energy expenditure and/or insufficient nutrient intake combined with physical and psychological stress, and low leptic levels. The end result is suppression of hypothalamic-hypophyseal function, which can affect a wide range of hormones.  It's energy deficiency from increased energy expenditure and/or insufficient nutrient intake, making the body think it's starving. It's not a healthy response, and now women are paying the price.

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Oregon ‘underemployment’ is rising rapidly.  The U-6 is going the wrong way. What's going to happen when people don't qualify for SNAP anymore and have to look for a job, but there are no jobs around because Oregon's economy sucks? Maybe people will move away. Maybe there will be more home break-ins. And since the police don't arrest crooks much anymore, and prosecutors seem to release criminals without charges, things will only get worse.

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The job where people get the most injuries are jobs at nursing and residential care facilities. Working at hospitals is #4. The society we live in now.

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